A5076668666- Photonic and Optical Devices
- Optical Network Technologies
- Neural Networks and Reservoir Computing
- Semiconductor Lasers and Optical Devices
- Advanced Photonic Communication Systems
- Ion Channels and Receptors
- Extracellular vesicles in disease
- Advanced Memory and Neural Computing
- Advanced Image and Video Retrieval Techniques
- Ion channel regulation and function
- MicroRNA in disease regulation
- Advanced Optical Network Technologies
- Photonic Crystals and Applications
- Neural dynamics and brain function
- Genetics, Aging, and Longevity in Model Organisms
- Circular RNAs in diseases
- Robotics and Sensor-Based Localization
- Advanced Fiber Laser Technologies
- Neuroscience and Neuropharmacology Research
- Transgenic Plants and Applications
- Semiconductor Quantum Structures and Devices
- Semiconductor materials and devices
- Photoreceptor and optogenetics research
- CRISPR and Genetic Engineering
- RNA modifications and cancer
Westlake University
2019-2025
Hewlett Packard Enterprise (United States)
2021-2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2021-2025
Southern Medical University
2024
Hainan University
2023-2024
Hewlett-Packard (United States)
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Fujian Medical University
2023
Xinxiang Medical University
2022-2023
Changzhou University
2022-2023
Abstract Senescent endothelial cells (ECs) could impair the integrity of blood vessel endothelium, leading to vascular aging and a series diseases, such as atherosclerosis, diabetes. Preventing or mitigating EC senescence might serve promising therapeutic paradigm for these diseases. Recent studies showed that small extracellular vesicles (sEV) have potential transfer bioactive molecules into recipient induce phenotypic changes. Since mesenchymal stem (MSCs) long been postulated an important...
Abstract Neurovascular coupling (NVC) is important for brain function and its dysfunction underlies many neuropathologies. Although cell-type specificity has been implicated in NVC, how active neural information conveyed to the targeted arterioles remains poorly understood. Here, using two-photon focal optogenetics mouse cerebral cortex, we demonstrate that single glutamatergic axons dilate their innervating via synaptic-like transmission between neural–arteriolar smooth muscle cell...
Although adipocytes are the most abundant stromal cell component in breast cancer tissues, their interaction with cells has been less investigated compared to cancer-associated fibroblasts or macrophages. Exosomes a novel way of cell-cell communication and have demonstrated play an important role various biological processes. However, our knowledge, only few studies reported effects adipocyte exosomes on tumor development. Here, utilizing isolated from vitro mesenchymal stromal/stem...
The initiation and progression of hepatocellular carcinoma (HCC) are largely dependent on its local microenvironment. Adipocytes an important component hepatic microenvironment in nonalcoholic fatty liver disease (NAFLD), which is a significant risk factor for HCC. Given the global prevalence NAFLD, better understanding interplay between HCC cells adipocytes urgently needed. Exosomes, released by malignant cells, represent novel way cell-cell interaction have been shown to play role cancer...
Recent advances in neuromorphic computing have established a computational framework that removes the processor-memory bottleneck evident traditional von Neumann computing. Moreover, contemporary photonic circuits addressed limitations of electrical platforms to offer energy-efficient and parallel interconnects independently distance. When employed as synaptic with reconfigurable elements, they can an analog platform capable arbitrary linear matrix operations, including multiply–accumulate...
Tris(2-chloroethyl) phosphate (TCEP) has been detected all over the world as a typical refractory organic phosphate, especially in groundwater. This work applied calcium-rich biochar derived from shrimp shell low-cost adsorbent for TCEP removal. Based on kinetics and isotherm studies, adsorption of was monolayer adsorbed uniform surface, with SS1000 (the prepared at carbonization temperature 1000 °C) achieving maximum capacity 264.11 mg·g−1. The demonstrated stable removal ability throughout...
Abstract UVB radiation induces oxidative stress, DNA damage, and inflammation, leading to skin wrinkling, compromised barrier function, an increased risk of carcinogenesis. Addressing or preventing photoaging may offer a promising therapeutic avenue for these conditions. Recent research indicated that mesenchymal stem cells (MSCs) exhibit significant potential various diseases. Given extracellular vesicles (EV) can deliver diverse cargo recipient elicit similar effects, we investigated the...
The convergence of deep learning and big data has spurred significant interest in developing novel hardware that can run large artificial intelligence (AI) workloads more efficiently. Over the last several years, silicon photonics emerged as a disruptive technology for next-generation accelerators machine (ML). More recently, heterogeneous integration III-V compound semiconductors opened door to integrating lasers semiconductor optical amplifiers at wafer-scale, enabling scaling size,...
Abstract Human crowd is a fascinating social phenomenon in nature. This paper presents our work on designing behavior model for virtual humans simulation under normal‐life and emergency situations. Our adopts an agent‐based approach employs layered framework to reflect the natural pattern of human‐like decision making process, which generally involves person's awareness situation consequent changes internal attributes. The group crowd‐related behaviors are modeled according findings theories...
Abstract The capsaicin receptor TRPV1 has been intensively studied by cryo-electron microscopy and functional tests. However, though the apo capsaicin-bound structural models are available, dynamic process of activation remains intangible, largely due to lack a capsaicin-induced open model low occupancy transition states. Here we report that reducing temperature toward freezing point substantially increased channel closure events even in presence saturating capsaicin. We further used...
Inflammatory bowel disease (IBD) remains a severe for most patients, with its incidence and prevalence increasingly globally.Currently, there is no effective treatments IBD, traditional have multiple side effects.Therefore, novel therapeutic strategies or alternative drugs are urgently needed.Previous studies shown that mesenchymal stem cell-derived exosomes exhibited promising effects on inflammatory disease.Here, we performed intravenous injection of human adipose cell (hADSC)-derived...
This paper proposes a large-scale, energy-efficient, high-throughput, and compact tensorized optical neural network (TONN) exploiting the tensor-train decomposition architecture on an integrated III–V-on-silicon metal–oxide–semiconductor capacitor (MOSCAP) platform. The proposed TONN is scalable to 1024 × synapses beyond, which extremely difficult for conventional ONN architectures by using cascaded multi-wavelength small-radix (e.g., 8 8) tensor cores. Simulation experiments show that uses...
Photonic spiking neural networks (PSNNs) potentially offer exceptionally high throughput and energy efficiency compared to their electronic neuromorphic counterparts while maintaining benefits in terms of event-driven computing capability. While state-of-the-art PSNN designs require a continuous laser pump, this paper presents monolithic optoelectronic hardware design consisting an MZI mesh incoherent network neurons. We designed, prototyped, experimentally demonstrated neuron inspired by...
Abstract Background: An altered pattern of epigenetic modifications is central to the development and progression various tumors. We studied changes involving multiple histones better predict prognosis glioma patients. Methods: Immunohistochemistry was done investigate global histone modification expression 3 lysine 4 dimethylation (H3K4diMe), arginine monomethylation (H4R3monoMe), 20 trimethylation (H4K20triMe), acetylation 9 (H3K9Ac), 18 (H3K18Ac), 12 (H4K12Ac), 16 (H4K16Ac) in resected...
Tissue acidosis and inflammatory mediators play critical roles in pain. Extracellular activates acid-sensing ion channels (ASICs), which have emerged as key sensors for extracellular protons the central peripheral nervous systems pain sensation transmission. Additionally, mediators, such serotonin (5-HT), are known to enhance sensation. However, functional interactions among protons, ASICs poorly understood. In present study, we show that 5-HT, a classical pro-inflammatory mediator,...
Mesenchymal stem cells (MSCs) have beneficial effects on wound healing.MSCs function through direct cell-cell communication or indirectly paracrine secretion of exosomes.Here, we found that MSCderived exosomes had pro-wound healing via promotion angiogenesis; however, this promoting effect was significantly reduced when senescence induced in parental MSCs by hydrogen peroxide (H2O2).Further experiments showed decreased miR-146a expression derived from senescent (s-exo) contributed to these...
We report on uniform emission intensity profile, propagation constant silicon gratings for beam steering application with ultra-sharp instantaneous field-of-view (IFOV). To achieve across relatively long length, we designed a custom grating varying Si3N4 width and duty cycle while maintaining narrow divergence pattern. fabricated the Si3N4/Si width/duty together reference 50:50 cycle. The demonstrated angle value of 6.6° by sweeping wavelength between 1530 nm 1575 length over 1 mm. measured...
At present, the glassy polymeric membrane technology for CO2 separation is still confronted with a predicament that it difficult to fabricate membranes both high permeance and gas selectivity. Fortunately, newly developed thin film composite (TFC) (∼100 nm) can facilitate permeation by minimizing trans-membrane resistance macrovoid defects. Herein, novel TFC containing polyimide (PI) selective layer on PDMS-modified PSf substrate was successfully constructed in situ an interfacial...
Partial differential equation (PDE) is an important math tool in science and engineering. This paper experimentally demonstrates optical neural PDE solver by leveraging the back-propagation-free on-photonic-chip training of physics-informed networks.
Genetically encoded voltage indicators (GEVIs) allow for the cell-type-specific real-time imaging of neuronal membrane potential dynamics, which is essential to understanding information processing at both cellular and circuit levels. Among GEVIs, near-infrared-shifted GEVIs offer faster kinetics, better tissue penetration, compatibility with optogenetic tools, enabling all-optical electrophysiology in complex biological contexts. In our previous work, we employed directed molecular...