A5102825711- Electrocatalysts for Energy Conversion
- Advanced battery technologies research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Aldose Reductase and Taurine
- Advanced Photocatalysis Techniques
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Nanoparticle-Based Drug Delivery
- Head and Neck Cancer Studies
- Heme Oxygenase-1 and Carbon Monoxide
- RNA regulation and disease
- Cancer Immunotherapy and Biomarkers
- Fuel Cells and Related Materials
- Fungal Biology and Applications
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
- Advanced biosensing and bioanalysis techniques
- Medicinal plant effects and applications
- Conducting polymers and applications
- Supramolecular Chemistry and Complexes
- Pharmacogenetics and Drug Metabolism
- Graphene and Nanomaterials Applications
- Copper-based nanomaterials and applications
Wuhan Institute of Technology
2021-2024
Yantai University
2024
Yuncheng Central Hospital
2024
Yuncheng University
2024
Shanxi Medical University
2024
Nanjing Medical University
2014-2023
Jiangsu Cancer Hospital
2013-2023
Kangda College of Nanjing Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2022
Peking Union Medical College Hospital
2020
Abstract Senescent endothelial cells (ECs) could impair the integrity of blood vessel endothelium, leading to vascular aging and a series diseases, such as atherosclerosis, diabetes. Preventing or mitigating EC senescence might serve promising therapeutic paradigm for these diseases. Recent studies showed that small extracellular vesicles (sEV) have potential transfer bioactive molecules into recipient induce phenotypic changes. Since mesenchymal stem (MSCs) long been postulated an important...
Nasopharyngeal carcinoma (NPC) is among the most common squamous cell in South China and Southeast Asia. Radiotherapy primary treatment for NPC. However, radioresistance acts as a significant factor that limits efficacy of radiotherapy NPC patients. Growing evidence supports microRNAs (miRNAs) play an important role radiation response. Real-time quantitative PCR was used to analyze expression miR-19b-3p lines NP69. profiles tissues were obtained from Gene Expression Omnibus database. The...
Inflammatory bowel disease (IBD) remains a severe for most patients, with its incidence and prevalence increasingly globally.Currently, there is no effective treatments IBD, traditional have multiple side effects.Therefore, novel therapeutic strategies or alternative drugs are urgently needed.Previous studies shown that mesenchymal stem cell-derived exosomes exhibited promising effects on inflammatory disease.Here, we performed intravenous injection of human adipose cell (hADSC)-derived...
Aldo-keto reductase 1C3(AKR1C3) is an enzyme involved in prostaglandins metabolism. Studies suggest that AKR1C3 has a pivotal role the radioresistance of esophageal cancer and non-small-cell lung cancer, yet prostate cells radiation resistance not been clarified. In our study, we established stable overexpressing cell line (AKR1C3-over) derived from DU145 its control (Control). We conducted colony formation assay to determine used chemical inhibitor detect whether it can restored sensitivity...
Esophageal squamous cell cancer is a highly aggressive with dismal 5-year survival rate. CD47 transmembrane protein that involved in apoptosis, proliferation, adhesion, migration, and antigen presentation the immune system. By interacting signal regulatory protein-α expressed antigen-presenting cells (APCs), acts as an antiphagocytic mechanism to inhibit APC-dependent presentation. Overexpression of was found various types cancer. However, its role esophageal not yet clear. Anti-CD47...
Mesenchymal stem cells (MSCs) have beneficial effects on wound healing.MSCs function through direct cell-cell communication or indirectly paracrine secretion of exosomes.Here, we found that MSCderived exosomes had pro-wound healing via promotion angiogenesis; however, this promoting effect was significantly reduced when senescence induced in parental MSCs by hydrogen peroxide (H2O2).Further experiments showed decreased miR-146a expression derived from senescent (s-exo) contributed to these...
Developing efficient and cost-effective bifunctional catalytic electrodes is of great importance to water splitting. In this study, hybrid Ni/Ni(OH)2-coated NiCo2O4 nanorods were grown on Ni foam (NF) by a facile growth–conversion–epitaxy approach. The epitaxial decoration Ni/Ni(OH)2 composite could increase the intrinsic activity NiCo2O4/NF enhance charge-transfer rate. This self-standing hierarchical nanohybrid with unique surface chemistry interface engineering exhibits an excellent...
The Health Action Process Approach (HAPA), developed by German psychologist Schwarzer in the 1980s, provides a comprehensive framework for understanding and influencing health behavior change. By dividing change into three dynamic stages—pre-intention, intention, action—HAPA highlights critical role of self-efficacy as driving force adopting healthier behaviors. This stage-based approach addresses limitations continuous models emphasizing individual differentiation recognizing that is not...
Huanglian ( Rhizoma Coptidis ) as a popular herb has been used for the treatment of various diseases such diarrhea, eye inflammation and women's abdominal ailments. Alkaloids are considered to be responsible its pharmacological effects. In this investigation, six alkaloids (coptisine, epiberberine, berberine, jateorrhizine, palmatine magnoflorine) were systematically evaluated their inhibition cytochrome P450 isoforms (CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6 CYP3A4) in human liver microsomes...
A new organic–inorganic hybrid material based on upconversion nanoparticles and pillarenes is constructed for cargo controlled delivery cell imaging.
Abstract Resistance to chemotherapy and molecularly targeted therapies is a major problem in current leukemia treatments. Here, we investigated cross-talk between the miR-221 network P-glycoprotein (P-gp) doxorubicin-induced drug resistance of cells. Multifunctional gold nanoparticles were designed synthesized co-deliver three anticancer agents, AS1411, doxorubicin anti-221, for improving treatment efficacy. These significantly inhibited proliferation clonogenic potential, induced apoptosis...
In diesel-ignited natural gas marine dual-fuel engines, the pilot diesel injection timing (PDIT) determines premixing time and ignition moment of combustible mixture in cylinder. The PDIT plays a crucial role subsequent development flame combustion. this paper, four PDITs (- 8 °CA, - 6 4 2 °CA) were studied. results show that advancement increased engine's power, thermal efficiency, spread velocity, NO emissions CH4 engine. affected delay period rapid combustion to greater extent than slow...
With the aim to elucidate etiology of radioresistance, we explored genetic alterations in non-radioresistant vs. resistant esophageal cancer cells acquired by long-term fractionated radiation. We found AKR1C3, an aldo-keto reductase expressed seldom most human tissues, higher radioresistance-acquired cells. Suppression AKR1C3 via RNAi or its chemical inhibitors restored sensitivity tumor and xenograft BALB/c nude mice ionizing radiation (IR). Cellular monitoring oxidative stress...
Tumor cells have higher rates of glucose uptake and aerobic glycolysis to meet energy demands for proliferation metastasis. The characteristics increased uptake, accompanied with glycolysis, has been exploited the diagnosis cancers. Although much progress made, mechanisms regulating tumor production are still not fully understood. Here, we demonstrate that Pim-2 is required in colorectal cells. Our results show highly expressed cells, may be induced by nutrient stimulation. Activation led...
Radiotherapy is the mainstay in treatment of prostate cancer. However, significant radioresistance castration-resistant cancer (CRPC) cells constitutes a main obstacle this disease. By using bioinformatic data mining methods, LOXL2 was found to be upregulated both androgen-independent cell lines and radioresistant tumor samples collected from patients with We speculate that may play an important role CRPC cells.The effect knockdown on radiosensitivity measured by clonogenic assay xenograft...
Objective LncRNA PART1 has been confirmed related to multiple cancer bioactivities mediated with vascular endothelial growth factor signaling. Nevertheless, the role of in esophageal induced angiogenesis remains unclear. The present work focused on assessing effects cancer–induced and exploring possible mechanisms. Methods Western blot immunofluorescence were conducted for identifying EC9706 exosomes. MiR-302a-3p levels assessed by real-time quantitative polymerase chain reaction. Cell...
The development of multifunctional electrocatalysts with rich resources, excellent performance, and stability is necessary for water splitting to achieve sustainable hydrogen oxygen production. Herein, we report the preparation a bifunctional coral-like nanostructured electrocatalyst (p-MoS2/NiS2) by in situ vulcanization polymeric sulfur MoO3/Ni as precursor. It exciting that whole process can be completed few hours. as-fabricated multimetallic sulfide not only exhibits well-defined...
Importance Peceleganan spray is a novel topical antimicrobial agent targeted for the treatment of skin wound infections. However, its efficacy and safety remain unclear. Objective To assess peceleganan Design, Setting, Participants This multicenter, open-label, phase 3 randomized clinical trial recruited followed up 570 adult patients diagnosed with secondary open infections from 37 hospitals in China August 23, 2021, to July 16, 2022. Interventions Patients were 2 groups 2:1 allocation. One...