A5102970179- T-cell and B-cell Immunology
- Mycorrhizal Fungi and Plant Interactions
- Fungal Biology and Applications
- Neutrino Physics Research
- Diamond and Carbon-based Materials Research
- Ion-surface interactions and analysis
- Particle physics theoretical and experimental studies
- Astrophysics and Cosmic Phenomena
- Genomics and Chromatin Dynamics
- Atomic and Subatomic Physics Research
- Wound Healing and Treatments
- Fermentation and Sensory Analysis
- Slime Mold and Myxomycetes Research
- RNA Research and Splicing
- Glycosylation and Glycoproteins Research
- Biocrusts and Microbial Ecology
- High-pressure geophysics and materials
- Nuclear Physics and Applications
- Dark Matter and Cosmic Phenomena
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Bee Products Chemical Analysis
Nanjing University
2023-2025
Collaborative Innovation Center of Advanced Microstructures
2023
National Laboratory of Solid State Microstructures
2023
Hankou University
2023
Albert Einstein College of Medicine
2021-2022
Cancer Genetics (United States)
2022
National Cancer Institute
2022
Center for Cancer Research
2022
Wuhan University
2012-2015
Ganoderma lucidum is a basidiomycete white rot fungus and of medicinal importance in China, Japan other countries the Asiatic region. To date, much research has been performed identifying ingredients lucidum. Despite its important therapeutic effects disease, little known about at genomic level. In order to gain molecular understanding this fungus, we utilized Illumina high-throughput technology sequence analyze transcriptome
Ganoderma lucidum is a basidiomycete white rot fungus that has been used for medicinal purposes worldwide. Although information concerning its genome and transcriptome recently reported, relatively little available G. at the proteomic level. In this study, protein fractions from three developmental stages (16-day mycelia, fruiting bodies 60 90 days) were prepared subjected to LC-MS/MS analysis. A search against database identified 803 proteins. Among these proteins, 61 lignocellulose...
Importance Peceleganan spray is a novel topical antimicrobial agent targeted for the treatment of skin wound infections. However, its efficacy and safety remain unclear. Objective To assess peceleganan Design, Setting, Participants This multicenter, open-label, phase 3 randomized clinical trial recruited followed up 570 adult patients diagnosed with secondary open infections from 37 hospitals in China August 23, 2021, to July 16, 2022. Interventions Patients were 2 groups 2:1 allocation. One...
Significance The somatic hypermutation of immunoglobulin (Ig) genes is usually required to make antibodies that protect us from foreign and toxic substances. This mutational process mediated by activation-induced deaminase (AID) targeted the variable (V) part Ig encode antigen-binding site antibody molecules, leading higher affinity more effective antibodies. AID acts on single-stranded DNA created during transcription V region. Here, we show multiple factors are involved in release, pausing...
Significance We have shown that the immunoglobulin heavy chain V region mutation in human B cells is regulated by HIRA, which a chaperone for H3.3, and found H3.3 plays role part through its H3.3K36me3 modification. The absence of HIRA associated with change chromatin accessibility. depletion expression H3.3G34V mutant also decreased recruitment several transcriptional elongation factors, including ZMYND11, had not previously been to be involved mutation. These other findings extend our...
Abstract Activation-induced cytidine deaminase (AID) somatically hypermutates the immunoglobulin heavy chain variable region (IGHV) gene to create antibody diversity required resist infections. This hypermutational process involves many pathways including transcription, DNA structural change and repair. While of proteins involved have been identified, their relative abundance, organization regulation not resolved additional factors need be identified. To identify proteome occupying IGHV, we...
Abstract The histone variant H3.3 and its chaperone HIRA are involved in active transcription but their detailed roles regulating somatic hypermutation (SHM) human B cells have not been fully elucidated. Here we found that the knockout (KO) of significantly decreased SHM Ramos germinal center like cell line without changing levels AID other major proteins known to be SHM. KO was associated with a decrease at immunoglobulin (Ig) heavy chain locus many factors related elongation including this...
The Jiangmen Underground Neutrino Observatory (JUNO) experiment is the next-generation neutrino that aims at exploring mass hierarchy problem. Located 700m underground in Jiangmen, China, JUNO’s central detector an acrylic sphere filled with 20kt of liquid scintillator linear alkylbenzene (LAB) as solvent. To achieve unprecedented energy resolution σE/E⩽3%, LAB used JUNO required for excellent transparency wavelength around 430nm. In cooperation Jinling Petrochemical (Nanjing), newly...