A5102011579- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Ion Transport and Channel Regulation
- Immune cells in cancer
- Ion channel regulation and function
- Sirtuins and Resveratrol in Medicine
- Neurological disorders and treatments
- Angiogenesis and VEGF in Cancer
- Cardiac Ischemia and Reperfusion
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Cells and Metastasis
- Cardiac, Anesthesia and Surgical Outcomes
- Heavy Metal Exposure and Toxicity
- MicroRNA in disease regulation
- Cardiac Arrest and Resuscitation
- Wound Healing and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Single-cell and spatial transcriptomics
- Immunotoxicology and immune responses
- Caveolin-1 and cellular processes
Third Affiliated Hospital of Sun Yat-sen University
2022-2025
Sun Yat-sen University
2020-2025
Affiliated Hospital of Hangzhou Normal University
2014-2025
Hangzhou Dianzi University
2024
Ningbo University
2023-2024
Jinan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
UPMC Hillman Cancer Center
2023
University of Pittsburgh
2021-2023
Taiyuan University of Technology
2023
Background Patients undergoing liver transplantation (LT) are at risk of perioperative neurocognitive dysfunction (PND), which significantly affects the patients’ prognosis. Objective This study used machine learning (ML) algorithms with an aim to extract critical predictors and develop ML model predict PND among LT recipients. Methods In this retrospective study, data from 958 patients who underwent between January 2015 2020 were extracted Third Affiliated Hospital Sun Yat-sen University....
Purpose The rapid development of information technology, epitomized by AIGC and the metaverse, presents unprecedented challenges to techno-ethics, exposing society significant risks uncertainties. A systematic investigation discussion construction techno-ethical order become crucial under paradigm risk theory. selection conditions pathways for constructing a theory becomes an unavoidable vital issue. Design/methodology/approach Drawing on theory, this study employs scientometrics qualitative...
Intestinal ischemia/reperfusion (I/R) injury is a common life-threatening condition. Inflammatory dysregulation plays crucial role in the pathological progression of intestinal I/R injury, indicating that controlling excessive inflammatory responses can be an effective strategy for mitigating injury. Herein, after establishing correlation between cell-free DNA (cfDNA) levels and postoperative factors samples from patients with I/R, we tested cfDNA-scavenging approach treatment...
Perioperative neurocognitive disorder (PND) is a common complication in surgical patients. While many interventions to prevent PND have been studied, the availability of treatment methods limited. Thus, it crucial delve into mechanisms PND, pinpoint therapeutic targets, and develop effective approaches. In this study, reduced dorsal tenia tecta (DTT) neuronal activity was found be associated with tibial fracture surgery-induced indicating that excitation–inhibition (E–I) imbalance could...
Chronic intermittent hypobaric hypoxia (CIHH) has been shown to attenuate intracellular Na(+) accumulation and Ca(2+) overload during ischemia reperfusion (I/R), both of which are closely related the outcome myocardial damage. Na/K pump plays an essential role in maintaining equilibrium I/R. It that enhancement activity by ischemic preconditioning may be involved cardiac protection. Therefore, we tested whether was cardioprotection CIHH. We found current myocytes guinea pigs exposed CIHH...
Propofol is a general anesthetic option for deep brain stimulation (DBS) of the subthalamic nucleus (STN) patients with Parkinson's disease (PD). However, its effects on STN activity and neuropsychological outcomes are controversial. The optimal propofol anesthesia asleep DBS unknown. This study investigated safety effectiveness an optimized regimen in DBS.This retrospective enrolled 68 PD undergoing bilateral STN-DBS surgery. All received local scalp anesthesia, (asleep group, n = 35) or...
Importance Peceleganan spray is a novel topical antimicrobial agent targeted for the treatment of skin wound infections. However, its efficacy and safety remain unclear. Objective To assess peceleganan Design, Setting, Participants This multicenter, open-label, phase 3 randomized clinical trial recruited followed up 570 adult patients diagnosed with secondary open infections from 37 hospitals in China August 23, 2021, to July 16, 2022. Interventions Patients were 2 groups 2:1 allocation. One...
Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) play a critical role in resistance to immunotherapy. In this study, we identified epidermal growth factor-like 6 (Egfl6) as new regulator of myeloid cell functions. Our analyses indicated that Egfl6, via binding with β3 integrins activation p38 SYK signaling, acts chemotactic factor for migration promotes their differentiation towards an immunosuppressive state. syngeneic mouse models ovarian cancer (OvCa),...
Cadmium (Cd) is a known environmental pollutant that associated with inflammation, oxidative stress, and cell apoptosis. Astragalus polysaccharide (APS) major component of membranaceus, vital qi-reinforcing herb medicine favorable immuneregulation properties. To study the effect APS on inhibition cadmium-induced injury peripheral blood lymphocytes (PBLs) in chickens through MDA5/NF-κB signaling pathway, PLBs acquired from 15-day-old were divided into control group, Cd + anti-MDA5 mAb BAY...
It has been shown that combined liver-kidney normothermic machine perfusion (NMP) is able to better maintain the circuit's biochemical milieu. Nevertheless, whether superior liver alone in protecting livers from donation after circulatory death (DCD) unclear. We aimed test hypothesis and explored mechanisms. Livers 15 DCD pig donors were subjected either static cold storage (group A), liver-alone NMP B), or C). preserved for 6 hours reperfused ex vivo 2 simulate transplantation transplanted...