A5067054158- Cancer-related Molecular Pathways
- Thyroid Cancer Diagnosis and Treatment
- Neurological disorders and treatments
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Intensive Care Unit Cognitive Disorders
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Studies
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Cancer survivorship and care
- Ubiquitin and proteasome pathways
- Anesthesia and Sedative Agents
- Clinical practice guidelines implementation
- Traditional Chinese Medicine Analysis
- Delphi Technique in Research
- Autophagy in Disease and Therapy
- Anesthesia and Neurotoxicity Research
- Radiomics and Machine Learning in Medical Imaging
- Acupuncture Treatment Research Studies
- AI in cancer detection
- Cancer Immunotherapy and Biomarkers
Guangzhou University of Chinese Medicine
2019-2024
Chinese Academy of Sciences
2016-2023
First Affiliated Hospital of Zhengzhou University
2020-2023
Institute of Hydrobiology
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2022
The First Affiliated Hospital, Sun Yat-sen University
2021-2022
Sun Yat-sen University
2021-2022
Huazhong University of Science and Technology
2019-2022
Peking University Shougang Hospital
2021-2022
RMIT University
2022
Background: Mechanically ventilated patients in the intensive care unit (ICU) have high mortality rates. There are multiple prediction scores, such as Simplified Acute Physiology Score II (SAPS II), Oxford Severity of Illness (OASIS), and Sequential Organ Failure Assessment (SOFA), widely used general ICU population. We aimed to establish scores on mechanically with combination these disease severity other features available first day admission. Methods: A retrospective administrative...
Metformin, the most widely administered oral anti‑diabetic therapeutic agent, exerts its glucose-lowering effect predominantly via liver kinase B1 (LKB1)-dependent activation of adenosine monophosphate-activated protein (AMPK). Accumulating evidence has demonstrated that metformin possesses potential antitumor effects. However, whether is LKB1/AMPK signaling pathway remains to be determined. In current study, effects on proliferation, cell cycle progression, and apoptosis human non‑small...
Purpose Computer‐aided diagnosis (CAD) systems assist in solving subjective problems that typically rely on personal experience. A CAD system has been developed to differentiate malignant thyroid nodules from benign ultrasound images based deep learning methods. The diagnostic performance was compared between the and experienced attending radiologists. Methods image dataset for training included 651 386 while database testing 422 128 nodules. All were confirmed by pathology results. In...
Abstract Depression is a leading cause of disability worldwide. Here, we explored the role HMGB1-RAGE pathway in lipopolysaccharide (LPS)-induced depression-like behavior and microglial autophagy flux, neuroinflammation, polarization mouse model. Male C57BL/6 mice were infused with LPS abdominal cavity to induce depression They then underwent testing assess cognition. Real-time fluorescent quantitative polymerase chain reaction was used detect expression M1/M2 microglia markers, HMGB1, RAGE....
Abstract Protected areas are increasingly being promoted as an important means of protecting freshwater biological diversity and ecological processes. A robust assessment changes in protected is fundamental to optimize conservation policies adaptive management. China's efforts establish aquatic reserves have attracted worldwide attention, especially the “10‐year fishing ban” implemented Yangtze River basin. We focused on Liangzi Lake, a area basin, understand effect ban occurring after short...
Abstract Introduction Postoperative delirium is one of the most common and dangerous psychiatric complications after hip surgery. The aim this study was to investigate incidence postoperative in elderly patients fracture surgery identify risk factors for such, as part developing a stratification index (RSI) system predict patient's delirium. Methods Elderly (aged 65 years or older) with fractures who had received surgical treatment our hospital between March 2018 December 2019 were...
Downregulation of p57 Kip2 is involved in tumor progression, and S-phase kinase-associated protein 2 (Skp2) an E3 ligase that regulates a variety cell cycle proteins. However, the prognostic value its correlation with Skp2 breast cancer have not been fully elucidated. Here we report our study on expression 102 patients by immunohistochemistry, analysis clinicopathologic parameters relation to patient prognosis. The was negatively associated ( r = −0.26, P 0.009). Kaplan–Meier indicated both...
Propofol is a general anesthetic option for deep brain stimulation (DBS) of the subthalamic nucleus (STN) patients with Parkinson's disease (PD). However, its effects on STN activity and neuropsychological outcomes are controversial. The optimal propofol anesthesia asleep DBS unknown. This study investigated safety effectiveness an optimized regimen in DBS.This retrospective enrolled 68 PD undergoing bilateral STN-DBS surgery. All received local scalp anesthesia, (asleep group, n = 35) or...
Abstract Purpose This study was performed to investigate the efficacy and safety of combined immunotherapy antiangiogenic therapy for advanced non-small cell lung cancer (NSCLC) in real world. Methods Data on clinicopathological features, adverse events (AEs) were collected retrospectively NSCLC patients who received with therapy. Results A total 85 enrolled. The had a median progression-free survival (PFS) 7.9 months overall (OS) 18.60 months. objective response rate disease control 32.9%...
The effect of breast cancer neoadjuvant chemotherapy (NCT) is strongly associated with long term survival, especially when patients get a pathological complete response (PCR). It always still unknown which patient the potential one to PCR in NCT. Thus, we have seeded blood-derived metabolite biomarkers predict NCT cancer.Patients who received either 6 or 8 cycles anthracycline-docetaxel-based (EC-T TEC) had been assessed their chemotherapy-partial (PR) (n=19) and stable disease (SD) (n=16)....
Recent studies have demonstrated that SMG-1, a newly characterized member of the family phosphatidylinositol 3-kinase-related protein kinases (PIKKs), is involved in tumorigenesis as new tumor suppressor. However, its expression and significance hepatocellular carcinoma (HCC) remain obscure. The present study investigated SMG-1 HCC tissue specimens, aimed at defining association with clinicopathological significance. Both immunohistochemistry qRT-PCR were employed to analyze 157...
Astragaloside IV (AS-IV) is extracted from Astragalus membranaceus (Fisch.) Bunge (Fabaceae). However, its effects on endothelial cell injury remain unclear.To investigate the mechanisms underlying of AS-IV lipopolysaccharide (LPS)-induced in vitro.Human umbilical vein cells (HUVECs) were pre-treated with (100 µmol/mL), 4-hydroxy-3-methoxyacetophenone (APO, 10 N-acetylcysteine (NAC, 50 µmol/mL) and Ac-YVAD-cmk (AC, 5 for 2 h before 1 μg/mL LPS 24 exposure. Untreated cultured without any...
p57 and Ras homology A (RhoA) have been implicated in the growth metastasis of several types human cancers. This study aimed to detect their expression hepatocellular carcinoma (HCC) tissue specimens determine a possible association with clinicopathological data patient survival. total 80 HCC corresponding distant normal were processed for immunohistochemical qPCR analyses RhoA expression. The showed that mRNA protein was reduced tissues when compared non-cancer (P<0.05), while significantly...
Objective . The aim of this study was to establish the standardization syndrome differentiation operative breast cancer treated with Traditional Chinese Medicine (TCM) by modified Delphi method. Method A literature search for conducted and eligible articles were identified in indexed databases from 1982 2013. We carried out two rounds investigation between March October 2013 organized 20 experts who focused on TCM or integrative medicine research. Experts’ judgments collected via posted...