A5083102596- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Anesthesia and Pain Management
- Mitochondrial Function and Pathology
- Intracranial Aneurysms: Treatment and Complications
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Anesthesia and Sedative Agents
- Cancer, Hypoxia, and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neural Engineering
- Thermal Regulation in Medicine
- Transcranial Magnetic Stimulation Studies
- Lipoproteins and Cardiovascular Health
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Genetic Neurodegenerative Diseases
- Metabolism and Genetic Disorders
- Organ Transplantation Techniques and Outcomes
- Trigeminal Neuralgia and Treatments
- Cardiac Ischemia and Reperfusion
- ATP Synthase and ATPases Research
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
Jiaxing University
2025
King University
2025
Peking University
2025
Lanzhou University
2018-2024
Ningxia Medical University
2024
Tianjin Chest Hospital
2021-2024
Tianjin University
2024
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2024
Myocardium irreversibly injured by ischemic stress must be efficiently repaired to maintain tissue integrity and contractile performance. Macrophages play critical roles in this process. These cells transform across a spectrum of phenotypes accomplish diverse functions ranging from mediating the initial inflammatory responses that clear damaged subsequent reparative help rebuild replacement tissue. Although macrophage transformation is crucial myocardial repair, events governing are poorly...
h e ffe c t s o f p a i m / reperfusion (I/R) injury on store-operated calcium channel (SOC) currents (ISOC) in freshly isolated rat Kupffer cells, and the effects of Ca 2+ blockers, 2-aminoethoxydiphenyl borate (2-APB), SK&F96365, econazole miconazole, ISOC cells after hepatic I/R injury. METHODS:The model was established.Whole-cell patch-clamp techniques were performed to investigate 2-APB, miconazole I /R RESULTS: significantly increased from -80.4 ± 25.2pA -159.5 34.5pA ( b P < 0.01, n =...
Prolonged retention of tracheostomy tubes post-procedure often leads to complications, including granulation tissue overgrowth, airway narrowing, and laryngeal edema, necessitating delayed removal the tube. Currently, a definitive therapeutic regimen capable simultaneously resolving these complications expediting decannulation remains elusive. Herein, we present an efficacious strategy addressing morbidities facilitating rapid tube removal. A 44-year-old male patient, who had undergone due...
Abstract Aims The prediction of atrial fibrillation (AF) progression and post-ablation recurrence is currently based on empirical estimates, leading to suboptimal predictive accuracy. This study investigates whether remodelling, a key factor in the severity cardiomyopathy, could serve as shared substrate influencing both AF recurrence. We aimed identify circular RNAs (circRNAs) associated with remodelling evaluate their ability predict Methods results assessed differential expression plasma...
Tegoprazan (LXI-15028), a novel potassium-competitive acid blocker, has shown great efficacy in treating acid-related disorders. However, its metabolic and excretion characteristics are not fully understood. A single oral dose of 50 mg/150 μCi [14C]tegoprazan was administered to six healthy subjects. Blood, urine fecal samples were collected measured for total radioactivity (TRA), tegoprazan metabolites. Its safety also assessed. The maximum concentrations (Cmax) TRA plasma 634 ng/mL 990 ng...
Propofol is a general anesthetic option for deep brain stimulation (DBS) of the subthalamic nucleus (STN) patients with Parkinson's disease (PD). However, its effects on STN activity and neuropsychological outcomes are controversial. The optimal propofol anesthesia asleep DBS unknown. This study investigated safety effectiveness an optimized regimen in DBS.This retrospective enrolled 68 PD undergoing bilateral STN-DBS surgery. All received local scalp anesthesia, (asleep group, n = 35) or...
The purpose of the study was to assess relationship between preoperative laboratory examination, clinical imaging data, and postoperative death patients with acute type A aortic dissection (ATAAD) establish a prediction model hospital risk after operation.A total 224 cases Standford were treated by arch replacement using tetrafurcate graft stented elephant trunk implantation in Tianjin Chest Hospital. Based on examination data ATAAD, independent factors obtained logistic analysis,...
Carina resection and reconstruction is required when a tracheal tumor invades the carina. It relatively complicated surgical procedure that requires complex to maintain airway continuity. The technical difficulty lies in minimizing influence of anesthetic endotracheal intubation maintaining good ventilation function during surgery by establishing appropriate channels, which are contradictory many cases. Therefore, order achieve optimal outcome, we performed intratracheal carina with help...
Traditional DBS is usually conducted under local anesthesia (LA) which intolerable to some patients, general (GA) was opted extended surgical indication. This study aimed compare the efficacy and safety of bilateral subthalamic deep brain stimulation (STN-DBS) for Parkinson's disease (PD) asleep awake state in 1-year postoperative follow-up.Twenty-one PD patients were assigned group 25 group. Patients received STN-DBS different state. The participants interviewed assessed preoperatively at...
Cardiac hypertrophy is a pathophysiological response to harmful stimuli. The continued presence of cardiac will ultimately develop into heart failure. mitochondrion the primary organelle energy production, and its dysfunction plays crucial role in progressive development failure from hypertrophy. Hispidulin, natural flavonoid, has been substantiated improve metabolism inhibit oxidative stress. However, how hispidulin regulates underlying mechanism remains unknown. We found that significantly...
Background: After deep brain stimulation (DBS), hiccups as a complication may lead to extreme fatigue, sleep deprivation, or affected prognosis. Currently, the causes and risk factors of postoperative are unclear. In this study, we investigated for after DBS subthalamic nucleus (STN) Parkinson’s disease (PD) under general anesthesia. Methods: We retrospectively included patients who underwent STN in collected data demographic characteristics, clinical evaluations, medications. According...
Minimally invasive rotary resection (MIRR) is crucial for diagnosing and treating breast tumors, but the optimal intravenous anesthesia regimen unclear. Esketamine, an NMDA receptor antagonist with anesthetic, analgesic, sympathomimetic properties, may provide ideal adjunct to propofol sedation. This study aims compare safety efficacy of esketamine versus sufentanil as adjuncts analgesia sedation during MIRR.
We report the anesthetic management of a case separation craniopagus twins with unbalanced cross circulation and one twin renal dysfunction. After intravenous induction, anesthesia was maintained isoflurane inhalation propofol infusion. Twin A survived but B died after surgery. The problems during operation are discussed.
Postoperative delirium can increase cognitive impairment and mortality in patients with Parkinson's disease. The purpose of this study was to develop internally validate a clinical prediction model after deep brain stimulation the subthalamic nucleus disease under general anesthesia.We conducted retrospective observational cohort on data 240 who underwent anesthesia. Demographic characteristics, evaluation, imaging data, laboratory surgical anesthesia information were collected. Multivariate...
Abstract Background To review the incidence and extent of peri‐electrode edema after DBS to clarify effect postoperative use steroids on edema. Methods This retrospective cohort study included 250 patients who underwent bilateral subthalamic nucleus (STN) surgery with intact MRI within 1 month surgery. Patients were divided into steroid non‐steroid groups, based use. The occurrence compared between two other associated factors analyzed using univariate multivariate methods. Results...
Abstract Myocardial fibrosis detected by cardiac magnetic resonance (CMR) has been reported in patients with desmin‐related myopathy, although its characteristics remain unclear. Here, we describe a case of restrictive cardiomyopathy wherein CMR imaging revealed myocardial oedema, ischaemia, and the left ventricle; different types processes injury were CMR. Middle wall ventricular enhancement may be feature late gadolinium enhancement, lateral is often involved cases injury. useful for early...
Department of Anesthesia, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China
Background: Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective method for treating Parkinson’s disease (PD). However, safety of STN-DBS PD patients with cardiovascular (CVD) comorbidity rarely focused and reported. The aim this study to investigate the efficacy CVD comorbidity. Methods: We retrospectively included who underwent under general anesthesia in our center from January 2019 2021. Patient’s symptoms cardiopulmonary function were evaluated by a multi-disciplinary...
Background: Monitoring the depth of anesthesia by electroencephalogram (EEG) based on prefrontal cortex is an important means to achieve accurate regulation for subthalamic nucleus (STN) deep brain stimulation (DBS) under general in patients with Parkinson’s disease (PD). However, no previous study has conducted in-depth investigation into this monitoring data. Here, we aimed analyze characteristics EEG during DBS propofol PD and determine reference range parameters derived from monitoring....
Quantitative assessment of white blood flow in semi-oval center patients with delayed neuropathological sequelae (DNS) after carbon monoxide poisoning treated acupuncture combined hyperbaric oxygen (HBO) based on magnetic resonance multi-inversion time arterial spin labeling imaging (mTI-ASL), and to evaluate its efficacy indirectly.Twenty-six clinically diagnosed DNS were randomly divided into an observation group (13 cases) a control cases). The conventional therapy HBO given the group. In...