A5034555717- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Retinal Development and Disorders
- Lung Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Chronic Kidney Disease and Diabetes
- Neuroendocrine Tumor Research Advances
- Lipid metabolism and disorders
- Photoreceptor and optogenetics research
- Acupuncture Treatment Research Studies
- Dialysis and Renal Disease Management
- Cancer, Hypoxia, and Metabolism
- Cerebral Palsy and Movement Disorders
- Blood Pressure and Hypertension Studies
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Kidney Stones and Urolithiasis Treatments
- Anatomy and Medical Technology
- Research on Leishmaniasis Studies
Peking Union Medical College Hospital
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Lishui University
2023
Beijing Chest Hospital
2008-2023
Capital Medical University
2010-2023
Universidad del Noreste
2023
Southern Medical University
2004-2022
Nanfang Hospital
2004-2022
Dalian Medical University
2020-2022
Memorial Sloan Kettering Cancer Center
2017-2021
<ns4:p>Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages dendritic cells. IL-10 IL-12 play very important immunoregulatory roles in host defense immune homeostasis. Being anti- pro-inflammatory nature, respectively, their functions antagonistically opposing. A comprehensive in-depth understanding of immunological properties signaling mechanisms will help develop better clinical intervention strategies therapy for...
Background: Mechanically ventilated patients in the intensive care unit (ICU) have high mortality rates. There are multiple prediction scores, such as Simplified Acute Physiology Score II (SAPS II), Oxford Severity of Illness (OASIS), and Sequential Organ Failure Assessment (SOFA), widely used general ICU population. We aimed to establish scores on mechanically with combination these disease severity other features available first day admission. Methods: A retrospective administrative...
A 65-year-old male was admitted to Peking Union Medical College Hospital. The patient had intermittent fever for 2 months with a maximum body temperature of 39.3 ℃ and elevated serum creatinine levels 1 week. He no other suggestive symptoms or positive signs. Laboratory test results suggested acute kidney injury sharp elevation in lactic dehydrogenase levels. Abdominal enhanced computed tomography (CT) revealed multiple low-density lesions, further biopsy pathology demonstrated chronic...
Although Toll-like receptor 4 (TLR4)- and nucleotide-binding oligomerization domain 2 (NOD2)-mediated signaling mechanisms have been extensively studied individually, the crosstalk between them in regulation of intestinal mucosal defense tissue homeostasis has underappreciated. Here, we uncover some novel activities NOD2 by gene expression profiling revealing global nature cross-regulation TLR4- NOD2-mediated signaling. Specifically, is able to sense intensity TLR4-mediated signaling,...
This study investigated the function of SMAD3 (SMAD family member 3) in regulating PAX6 (paired box 6) non-small cell lung cancer. First, qRT-PCR was employed to detect expression cancer tissues along with normal and four lines, including BEAS-2B, H125, HCC827 A549 cells. knocked down by small interference RNA (siRNA), then its determined via Western blot analysis. The correlation between double luciferase reporter experiments chromatin immunoprecipitation (ChIP) assay. Cell viability...
We study the effect of acupuncture on brain activation patterns in children with cerebral palsy using functional magnetic resonance imaging (fMRI). fMRI whole was performed 11 and 10 healthy during stimulation a common acupoint Traditional Medicine [Liv3 (Taichong)] left foot. use both twisting nontwisting methods blocked paradigm 2.0 Tesla MRI scanner. Functional data were analyzed by Statistical Parametric Mapping software (SPM 99). Both signal increase decrease various regions found...
Three-dimensional (3D) visualization technology has been increasingly applied in patient-specific surgeries, but its value residency training not determined. This study aimed to explore the of 3D visualized pancreatic model tumor evaluation and surgery planning for surgical trainees. Eighty-eight residents were randomized into two groups (computed tomography (CT) group group). Both began with a on evaluating resectability tumor, which was based NCCN clinical practice guidelines practiced...
Abstract Progranulin (PGRN) is a widely expressed, pleiotropic protein that involved in diverse biological processes, including cellular proliferation, neuron development, and wound healing. However, the role of PGRN regulation pathogen-induced systemic inflammation mechanisms have not been established. In this study, we show PGRN-deficient mice display heightened mortality models polymicrobial sepsis endotoxinemia, with increased tissue levels inflammatory cytokines reduced IL-10...
In the livers of C57BL/6 mice, gamma interferon (IFN-γ) controls intracellular Leishmania donovani infection and efficacy antimony (Sb) chemotherapy. Since both responses usually correlate with granulomatous inflammation, we tested six prominently expressed, IFN-γ-regulated chemokines-CXCL9, CXCL10, CXCL13, CXCL16, CCL2, CCL5-for their roles in (i) mononuclear cell recruitment granuloma assembly maturation, (ii) initial control self-cure, (iii) responsiveness to Sb treatment. Together,...