A5100357977- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- Gallbladder and Bile Duct Disorders
- Neuroblastoma Research and Treatments
- Parathyroid Disorders and Treatments
- Lung Cancer Research Studies
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
University of Chicago
2017-2025
National Cancer Center Hospital East
2025
Cleveland Clinic
2025
Center for Life Sciences
2019-2024
Tsinghua University
2019-2024
Academy of Medical Sciences
2014-2024
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are epigenetic marks known to affect global gene expression in mammals. Given their prevalence the human genome, close correlation with high chemical stability, these could serve ideal biomarkers for cancer diagnosis. Taking advantage of a highly sensitive selective labeling technology, we report here genome-wide profiling 5hmC circulating cell-free (cfDNA) genomic (gDNA) paired tumor adjacent tissues...
Chemoresistance is one of the main causes poor prognosis in pancreatic cancer patients. Understanding mechanisms implicated chemoresistance critical to improving patient outcomes. Recent evidences indicate that long noncoding RNAs (lncRNAs) are involving cancer. However, lncRNAs contribute resistance and remain largely unknown. The objective this study construct a chemoresistance-related lncRNA-associated competing endogenous RNA (ceRNA) network identify key regulating network.Firstly,...
Background: Pancreatic cancer is highly lethal and aggressive with increasing trend of mortality in both genders. An effective prediction model needed to assess prognosis patients for optimization treatment. Materials methods: Seven datasets mRNA expression clinical data were obtained from gene omnibus (GEO) database. Level 3 clinicopathological The Cancer Genome Atlas pancreatic ductal adenocarcinoma (TCGA‑PAAD) dataset. Differentially expressed genes (DEGs) between tumor normal tissue...
Abstract Epigenetic modifications are defined as heritable changes in gene activity that do not involve the underlying DNA sequence. The oncogenic process is driven by accumulation of alterations impact genome's structure and function. Genetic mutations, which directly disrupt sequence, complemented epigenetic modulate expression, thereby facilitating acquisition malignant characteristics. Principals among these shifts methylation histone mark patterns, promote tumor development metastasis....
Preoperative localization of insulinoma is a clinical dilemma. We aimed to investigate whether glucagon-like peptide-1 receptor (GLP-1R) PET/CT with <sup>68</sup>Ga-NOTA-MAL-cys<sup>40</sup>-exendin-4 (<sup>68</sup>Ga-NOTA-exendin-4) efficient in detecting insulinoma. <b>Methods:</b> In our prospective cohort study, patients endogenous hyperinsulinemic hypoglycemia were enrolled. CT, MRI, endoscopic ultrasound, and <sup>99m</sup>Tc-hydrazinonicotinamide-TOC SPECT/CT done according standard...
The Chinese systemic lupus erythematosus (SLE) treatment and research group (CSTAR) provides major clinical characteristics of SLE in China establishes a platform to provide resources for future basic studies. CSTAR originated as multicentre, consecutive, prospective design. data were collected online from 104 rheumatology centers, which covered 30 provinces China. registered patients required meet four or more the American College Rheumatology (ACR) criteria classification SLE. All centers...
Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved controlling mTOR recruitment and activation, which is crucial for the growth both normal tumor cells. L-type transporter 2 (LAT2), encoded by SLC7A8 gene, a Na+-independent neutral responsible transporting acids, including glutamine, can activate mTOR. Previous studies shown that LAT2 was overexpressed gemcitabine-resistant pancreatic...
Insulinomas and non-functional pancreatic neuroendocrine tumours (NF-PanNETs) have distinctive clinical presentations but share similar pathological features. Their genetic bases not been comprehensively compared. Herein, we used whole-genome/whole-exome sequencing (WGS/WES) to identify differences between insulinomas NF-PanNETs.The mutational profiles copy-number variation (CNV) patterns of 211 PanNETs, including 84 127 NF-PanNETs, were obtained from WGS/WES data provided by Peking Union...
Abstract Glucose-regulated protein 78 (GRP78) is a member of the heat-shock 70 family. We evaluated expression GRP78 using tissue microarray-based immunohistochemistry in tumor tissues and adjacent nontumor from 180 pancreatic ductal adenocarcinoma (PDAC) patients. The associations between levels GRP78, clinicopathological factors overall survival were evaluated. results showed that was significantly higher PDAC cells than normal duct within (p < 0.05). increased correlated with T-stage...