A5100755112- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
- Pulmonary Hypertension Research and Treatments
- Rheumatoid Arthritis Research and Therapies
- Inflammatory Myopathies and Dermatomyositis
- Anorectal Disease Treatments and Outcomes
- Systemic Sclerosis and Related Diseases
- Spondyloarthritis Studies and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sarcoidosis and Beryllium Toxicity Research
- Colorectal Cancer Surgical Treatments
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Pelvic floor disorders treatments
- T-cell and B-cell Immunology
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Atherosclerosis and Cardiovascular Diseases
- Diverticular Disease and Complications
- Microbial metabolism and enzyme function
- Urticaria and Related Conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Macrophage Migration Inhibitory Factor
China Medical University
2024
First Hospital of China Medical University
2024
Yunnan University of Traditional Chinese Medicine
2024
Beijing Chao-Yang Hospital
2013-2023
Capital Medical University
2013-2023
Peking University
2013-2023
Peking University Third Hospital
2013-2023
Capital Health
2022
Capital University
2014
Seattle Children's Hospital
2009
The Chinese systemic lupus erythematosus (SLE) treatment and research group (CSTAR) provides major clinical characteristics of SLE in China establishes a platform to provide resources for future basic studies. CSTAR originated as multicentre, consecutive, prospective design. data were collected online from 104 rheumatology centers, which covered 30 provinces China. registered patients required meet four or more the American College Rheumatology (ACR) criteria classification SLE. All centers...
Objectives To estimate the prevalence of pulmonary arterial hypertension (PAH) and risk factors for PAH in patients registered Chinese SLE Treatment Research group (CSTAR) database, first online registry with systemic lupus erythematosus (SLE). Methods A prospective cross-sectional study was conducted using CSTAR registry. Resting transthoracic echocardiography used to artery pressure (PAP); defined as systolic PAP (PASP) ≥40 mmHg. Patients interstitial lung disease, valvular disease or...
Objective . To investigate the relationship between NLRP3 and pathogenesis of collagen-induced arthritis. Methods We used arthritis (CIA) mouse model. The mice were divided into two groups: model group (CIA,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">16</mml:mn></mml:math>) control (Normal,<mml:math id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">8</mml:mn></mml:math>). sacrificed seven...
This study aimed to identify the long-term clinical outcomes and prognostic factors of patients with systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension (PAH) confirmed by right heart catheterisation.A multicentre prospective cohort SLE-associated PAH was established. Baseline follow-up records were collected. The primary end-point death. secondary exploratory treatment goal achievement (TGA), defined as an integrated outcome.In total, 310 enrolled from 14 centres....
Objectives Primary Sjögren's syndrome (pSS) is an important cause of pulmonary arterial hypertension (PAH), which remains insufficiently studied and needs attention. This study aimed to investigate the clinical characteristics, risk factors, prognosis assessment pSS-PAH. Methods We established a multicentre cohort pSS-PAH diagnosed by right heart catheterisation. The case–control was conducted with pSS-non-PAH patients as control group identify factors for PAH. In study, survival calculated,...
We investigated the characteristics of Chinese SLE patients by analyzing association between specific autoantibodies and clinical manifestations 2104 from registry data CSTAR cohort. Significant (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle="italic">0.05</mml:mn></mml:math>) associations were found anti-Sm antibody, anti-rRNP malar rash; anti-RNP anti-SSA pulmonary arterial hypertension (PAH); anti-SSB antibody...
Bioprosthetic plugs represent a promising technique for the treatment of anal fistula simple because they allow and repeatable application, preservation sphincter integrity, minimal patient discomfort, subsequent surgical options if needed. However, success rates vary widely.The aim this study was to assess long-term outcome in patients treated with an acellular dermal matrix plug closure complex single-tract fistulas.This retrospective analysis prospective database.The conducted at...
Activation of cannabinoid receptor type 2 has been shown to have anti-fibrosis function in skin and heart. However, whether activating inhibits pulmonary fibrosis remains elusive. Lung fibroblasts TGF-β1 are key players the pathogenesis fibrosis. In this research, we aimed investigate role vitro vivo. lung stimulated by TGF-β1, preincubated agonist JWH133 not only reduced elevated levels collagen I α-SMA, but also inhibited fibroblasts' proliferation migration. The dosage had no clear...
Abstract Aim Pulmonary arterial hypertension (PAH) is a complex and devastating complication of systemic lupus erythematosus (SLE). We sought to describe the baseline characteristics right heart catheterization (RHC)‐confirmed SLE‐associated PAH identify risk factors for in SLE patients. Methods A multicenter, cross‐sectional study was conducted using Chinese Treatment Research group (CSTAR) registry. Baseline data patients with without were collected compared. Risk among identified. Results...
To analyze the clinical, serological, and imaging characteristics of patients with interstitial lung diseases (ILD) positive to different anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies.The clinical data, serological indexes, pulmonary high-resolution computed tomography (HRCT) features functions, bronchoalveolar lavage fluid 84 ILD anti-ARS antibody in Beijing Chao-yang Hospital, Capital Medical University were reviewed.(1) Anti-ARS antibodies included anti-Jo-1 (42.86%), anti-PL-7...
Ankylosing spondylitis (AS) is a highly heritable common inflammatory arthritis that targets the spine and sacroiliac joints of pelvis, causing pain stiffness leading eventually to joint fusion. Although previous studies have shown strong association IL23R with AS in white Europeans, similar East Asian populations no variants IL23R, suggesting either role or rare genetic contribute. The present study was undertaken screen identify associated Han Chinese.A 170-kb region containing its...
A previous study demonstrated that Lysyl oxidase‑like 2 (LOXL2) serves an essential role in matrix remodeling and fibrogenesis, thus indicating its involvement fibrosis‑associated diseases. Our studies revealed a novel association between LOXL2 expression pulmonary fibrosis mice. However, the exact mechanisms of interstitial lung disease remain poorly understood. The present aimed to detect mice with bleomycin (BLM)‑induced fibrosis, explore effects silencing on proliferation, activation...
Oxidative stress plays an essential role in inflammation and fibrosis. Bach1 is important transcriptional repressor that acts by modulating oxidative represents a potential target the treatment of pulmonary fibrosis (PF). In this study, we knocked down using adenovirus-mediated small interfering RNA (siRNA) to determine whether use siRNA effective therapeutic strategy mice with bleomycin (BLM)‑induced PF. Mouse lung fibroblasts (MLFs) were incubated transforming growth factor (TGF)-β1 (5...
Loxoprofen (LOX) is a nonsteroidal anti-inflammatory drug (NSAID). Although oral administration of LOX has been widely prescribed, clinical guidelines for osteoarthritis generally recommend topical rather than NSAIDs in specific patients. However, there limited information on the effects loxoprofen sodium (LOX-O) versus hydrogel transdermal patch (LOX-T) myalgia Hence, this non-inferiority study was designed to compare efficacy and safety LOX-O LOX-T Chinese patients with myalgia. In...
Nonsteroidal anti-inflammatory drugs are the first-line option for treating ankylosing spondylitis (AS) in China. However, no large-scale controlled trials have been conducted this ethnic population.To evaluate efficacy and safety of 6 weeks' treatment with celecoxib patients AS China.This Phase 3, double-blind, parallel-group study randomized aged ≥18 to 65 years 1:1 receive 200 mg once daily or diclofenac sustained release 75 daily. After weeks, could use 400 maintain blinded therapy. The...
Abstract Aim The aim of this study was to estimate the influence socioeconomic and geographical variables on disease phenotype activity systemic lupus erythematosus ( SLE ) in a Chinese population. Methods Data 904 therapy‐naïve patients from Treatment Research Group CSTAR ), which is nation‐wide database patients, were used evaluate status SES regions phenotypes. regional climate economic (i.e., data Statistical Yearly Annals) nephropathy further analyzed multivariate analysis identify some...