A5100691685- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Pelvic floor disorders treatments
- Gastric Cancer Management and Outcomes
- Hernia repair and management
- Sarcoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Tea Polyphenols and Effects
- Urological Disorders and Treatments
- Stress Responses and Cortisol
- Cancer Immunotherapy and Biomarkers
- Trigeminal Neuralgia and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Pelvic and Acetabular Injuries
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Surgical site infection prevention
- Tryptophan and brain disorders
- Cancer, Hypoxia, and Metabolism
- Advanced Glycation End Products research
Beijing Chao-Yang Hospital
2009-2024
Capital Medical University
2010-2024
Fudan University
2017-2024
Huashan Hospital
2017-2024
Beijing Chaoyang Emergency Medical Center
2009-2022
Xian Yang Central Hospital
2021
Zhejiang University
2020-2021
Cangzhou Central Hospital
2021
Yang Hospital
2019-2021
Nanjing University of Chinese Medicine
2021
Both inflammatory processes and glutamatergic systems have been implicated in the pathophysiology of mood-related disorders. However, role caspase-1, a classic caspase, behavioral responses to chronic stress remains largely unknown. To address this issue, we examined effects underlying mechanisms caspase-1 on preclinical murine models depression. We found that loss expression Caspase-1−/− knockout mice alleviated stress-induced depression-like behaviors, whereas overexpression hippocampus...
PURPOSE: Patients who undergo cylindrical abdominoperineal resection can have significant complications, especially those require pelvic reconstruction using myocutaneous flaps. Reconstruction a biomaterial may be novel alternative. The purpose of this study is to report the initial results human acellular dermal matrix after resection. METHODS: Between January 2008 and February 2009, floor was performed in 12 consecutive patients underwent for advanced ultralow rectal cancer. RESULTS: Two...
Recently, two different reports appeared in prominent journals suggesting a mechanism by which piperlongumine, pyridine alkaloid, mediates anticancer effects. In the current report, we describe another novel this alkaloid its We found that piperlongumine blocked NF-κB activated TNFα and various other cancer promoters. This downregulation was accompanied inhibition of phosphorylation degradation IκBα. Further investigation revealed directly interacts with IκBα kinase (IKK) inhibits activity....
BACKGROUND: Recent studies have shown that extralevator abdominoperineal resection has the potential for reduced circumferential margin involvement, intraoperative bowl perforation, and local recurrence rates; however, it been suggested extended may be associated with increased morbidity because of formation a larger perineal defect. OBJECTIVE: This study was undertaken to demonstrate feasibility complications locally advanced low rectal cancer in China. DESIGN: prospective cohort study....
Bioprosthetic plugs represent a promising technique for the treatment of anal fistula simple because they allow and repeatable application, preservation sphincter integrity, minimal patient discomfort, subsequent surgical options if needed. However, success rates vary widely.The aim this study was to assess long-term outcome in patients treated with an acellular dermal matrix plug closure complex single-tract fistulas.This retrospective analysis prospective database.The conducted at...
The purpose of this study was to compare the ligation intersphincteric fistula tract (LIFT) with an additional plug (LIFT-plug) in treatment transsphincteric anal fistula.Both LIFT and LIFT-plug are recently reported effective alternatives fistula.This multicenter prospective randomized (NCT01478139) conducted at 5 university hospitals throughout China. A total 235 patients were randomly assigned undergo (118 patients) or (117 between March 2011 April 2013. primary outcome measured healing...
Reconstruction of the pelvic floor defect caused by extralevator abdominoperineal excision poses a challenge for surgeon.The aim this study was to analyze long-term perineal wound complications in patients undergoing conventional primary closure versus biological mesh-assisted repair after excision.This single-institution retrospective observational study.The conducted at tertiary academic medical center.Patients with low advanced rectal cancer from August 2008 December 2016 (N = 228) were...
Sepsis is a heterogeneous syndrome caused by dysregulated host response during the process of infection. Neutrophils are involved in development sepsis due to their essential role defense. COVID-19 viral sepsis. Disfunction neutrophils has been described previous studies, however, little known about microRNA-let-7b (miR-let-7b), toll-like receptor 4 (TLR4), and nuclear factor kappa B (NF-κB) activity how they participate In this study, we investigated regulatory pathway miR-let-7b/TLR4/NF-κB...
The purpose of this study was to evaluate the oncologic and functional outcomes intersphincteric resection in ultralow rectal cancer.From 2000 2007, with total mesorectal excision performed 40 patients very low cancer (total 5 patients, partial 23 dentate line preservation [modified resection] 12 patients). preoperative tumor stage T12N01M0.Morbidity occurred three (anastomotic leakage one patient, wound infection two patients), but there no postoperative mortality. five-year overall...
This study aimed to evaluate the safety and feasibility of self-expanding metallic stent (SEMS) followed by neoadjuvant chemotherapy prior elective surgery for obstructing left-sided colon cancer.Eleven consecutive patients with cancer between May 2014 November 2015 were included retrospectively. All received SEMS chemotherapy. The primary outcome measure was stoma laparoscopic surgery.Chemotherapy two cycles CAPOX (54.5%) or three mFOLFOX6 (45.5%). Median serum albumin hemoglobin levels...
Stored red blood cell (RBC) transfusion has been shown to enhance the risk of cancer recurrence. However, underlying mechanism remains unknown. At our lab, we have demonstrated that extracellular ubiquitin (eUb) released by aged RBCs could promote tumor metastasis in a melanoma mouse model. This study aimed confirm pro-tumor effect eUb on hepatocellular carcinoma (HCC) and explore related immunoregulatory mechanisms.Forty HCC tissue specimens corresponding adjacent nontumor normal liver...
Hyperfibrinogenemia had been widely observed in various cancer patients, however, whether fibrinogen (FIB) influences the survival outcome of patients with primary liver (PLC) remains unknown. This study was aimed to evaluate predictive value preoperative FIB PLC and explore possible mechanism.
Bcl-2 family proteins play key roles in the intrinsic apoptosis pathway platelets, with both pro- and antiapoptotic protein expressions regulating survival during ex vivo storage. We detected a significant decrease Bcl-xL increase proapoptotic Bak expression on third day of storage as result ratio Bak:Bcl-xL also decreased. Moreover, we identified an interaction between Bak. These shifts corresponded activation apoptotic pathway, suggesting these might important role platelet survival. then...
BACKGROUND:An anal fistula plug is a sphincter-sparing procedure that uses biological substances to close an anorectal fistula. This study aimed evaluate the long-term therapeutic effect of in patients with trans-sphincteric fistula-in-ano and determine risk factors affecting healing. MATERIAL AND METHODS:A single-center retrospective was performed assessing treatment outcomes low fistulas who initially underwent procedures between August 2008 September 2012. Risk healing were identified...
BACKGROUND: Colonic stenting reduces morbidity and stoma formation for left-sided colon cancer obstruction, a prolonged interval between surgery with neoadjuvant chemotherapy administered might result in lower rate tumor reduction. OBJECTIVE: The study aimed to evaluate the short-term outcomes of elective following colonic compared patients obstruction. DESIGN: This is prospective multicenter cohort study. SETTINGS: was conducted at 5 medical centers. PATIENTS: Patients ( n = 100) acute...
To investigate the value of transanal multipoint full-layer puncture biopsy (TMFP) in predicting pathological complete response (pCR) after neoadjuvant radiotherapy and chemotherapy (nCRT) patients with locally advanced rectal cancer (LARC) to establish a predictive model for providing clinical guidance regarding treatment LARC.