A5058808674- Adipose Tissue and Metabolism
- Pain Mechanisms and Treatments
- Diet and metabolism studies
- Birth, Development, and Health
- Nitric Oxide and Endothelin Effects
- Cardiovascular Effects of Exercise
- Adipokines, Inflammation, and Metabolic Diseases
- Mitochondrial Function and Pathology
- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Cardiovascular Issues in Pregnancy
- Exercise and Physiological Responses
- Antioxidant Activity and Oxidative Stress
- Bone Metabolism and Diseases
- Cardiovascular Function and Risk Factors
- Gestational Diabetes Research and Management
- Pulmonary Hypertension Research and Treatments
- Metabolomics and Mass Spectrometry Studies
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Bone health and osteoporosis research
- Ion channel regulation and function
- Gut microbiota and health
- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
The University of Texas at San Antonio
2017-2025
University of Colorado Boulder
2008-2024
In-Q-Tel
2024
GTx (United States)
2024
Institute of Rheological Functions of Food
2023
Chungnam National University
2010-2023
SOUSEIKAI Global Clinical Research Center
2021
Texas Tech University
2013-2017
Texas Tech University Health Sciences Center
2016-2017
Washington State University
2003-2016
Although the signaling pathways underlying exercise-induced cardiac adaptation have been extensively studied, little is known about molecular mechanisms that result in response of heart to pregnancy. The objective this study was define morphological, functional, and gene expression patterns hearts pregnant mice, identify mediate response. Mice were divided into three groups: nonpregnant diestrus control, midpregnancy, late Both time points pregnancy associated with significant hypertrophy....
Calcium fluctuations and cardiac hypertrophy occur during pregnancy, but the role of well-studied calcium-activated phosphatase, calcineurin, has not been studied in this setting. The purpose study was to determine whether calcineurin signalling is required for remodelling pregnancy mice.We first examined expression heart mice pregnancy. We found both levels activity were significantly increased early-pregnancy decreased late-pregnancy. Since progesterone start rise early-pregnancy, we...
Emerging evidence suggests that the gut microbiome plays an important role in pathophysiology of both obesity and type 2 diabetes mellitus. We previously reported dietary annatto-extracted tocotrienol exerts beneficial effects by modulating inflammatory responses mice fed a high-fat diet (HFD). The purpose this study was to test hypothesis supplementation when combined with HFD would result altered microbiota composition. For 14 weeks, forty-eight male C57BL/6J were assigned 4 groups-low-fat...
Many organisms have intimate associations with beneficial microbes acquired from the environment. These host-symbiont can be specific and stable, but they are prone to lower partner specificity more partner-switching than vertically transmitted mutualisms. To investigate in an environmentally insect symbiosis, we used 16S rRNA gene multilocus sequencing survey bacterial population bacteria-harbouring organ (crypts) of 49 individuals across four sympatric broad-headed bug species (Alydus...
Background Although the hypertrophic responses of heart to pregnancy and exercise are both considered be physiological processes, they occur in quite different hormonal temporal settings. In this study, we have compared global transcriptional profiles left ventricular tissues at various time points during progression hypertrophy pregnancy. Methodology/Principal Findings The following groups female mice were analyzed: non-pregnant diestrus cycle sedentary control, mid-pregnant, late-pregnant,...
Diabetes is a risk factor for osteoporosis. Annatto-extracted tocotrienols (TT) have proven benefits in preserving bone matrix. Here, we evaluated the effects of dietary TT on glucose homeostasis, properties, and liver pro-inflammatory mRNA expression high-fat diet (HFD)-induced type 2 diabetic (T2DM) mice. 58 male C57BL/6 J mice were divided into 5 groups: low-fat (LFD), HFD, HFD + 400 mgTT/kg (T400), 1600 (T1600), 200 mg metformin/kg (Met) 14 weeks. Relative to group, both TT-supplemented...
The sarcomeric myosin gene, Myh7b, encodes an intronic microRNA, miR-499, which regulates cardiac and skeletal muscle biology, yet little is known about its transcriptional regulation. To identify the transcription factors involved in regulating Myh7b/miR-499 gene expression, we have mapped start sites identified upstream 6.2 kb region of mouse Myh7b whose activity mimics expression pattern endogenous both vitro vivo. Through promoter deletion analysis, a distal E-box element proximal Ikaros...
Abstract Maternal exercise during pregnancy has been shown to improve the long‐term health of offspring in later life. Mitochondria are important organelles for maintaining adequate heart function, and mitochondrial dysfunction is linked cardiovascular disease. However, effects maternal on biogenesis hearts not well understood. Thus, purpose this study was test hypothesis that gene expression fetal myocardium would be upregulated by exercise. Twelve‐week‐old female C57 BL /6 mice were...
Geranylgeraniol (GGOH) is found in edible oils such as olive, linseed, and sunflower oils, which have favorable metabolic effects. However, it unknown whether these physiological benefits are mediated through the gut microbiome. Thus, purpose of this study was to test hypothesis that GGOH supplementation would improve glucose homeostasis benefit bone microstructure obese mice suppression inflammation modification microbiota composition. Thirty-six male C57BL/6J were divided into 3 groups: a...
Objective To examine food insecurity (FI) prevalence among college students during the COVID-19 pandemic (April 2021) using cross-sectional design, and moderating role of first-generation student status in relationship between FI grade point average (GPA).Participants Three-hundred sixty recruited mostly from upper-level kinesiology coursesMethods General linear model was used to predict GPA based on security status, psychological health, bodily pain, with subgroup analysis performed by...
SUMMARY The heart is a highly plastic organ that responds to diverse stimuli modify form and function. molecular mechanisms of adaptive physiological cardiac hypertrophy are well-established; however, the regulation regression poorly understood. To identify features regression, we studied Burmese pythons which experience reversible following large, infrequent meals. Using multi-omics screens followed by targeted analyses, found forkhead box protein O1 (FoxO1) transcription factor signaling,...
Myocardial function is enhanced by endurance exercise training, but the cellular mechanisms underlying this improved remain unclear. The ability of myocardium to perform external work a critical aspect ventricular function, previous studies myocardial adaptation training have been limited measurements isometric tension or unloaded shortening velocity, conditions in which output zero. We measured force-velocity properties single permeabilized myocyte preparations determine effect on loaded...