A5041840092- Gut microbiota and health
- Ginger and Zingiberaceae research
- Bacterial biofilms and quorum sensing
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Advanced Chemical Sensor Technologies
- Pharmacological Effects and Toxicity Studies
- Antibiotic Resistance in Bacteria
- Metabolomics and Mass Spectrometry Studies
- Dermatology and Skin Diseases
- Olfactory and Sensory Function Studies
- Clostridium difficile and Clostridium perfringens research
- Genetics, Bioinformatics, and Biomedical Research
- Biochemical Analysis and Sensing Techniques
- Oral microbiology and periodontitis research
- Diet, Metabolism, and Disease
- Genetic and Environmental Crop Studies
- Bacterial Genetics and Biotechnology
- Pain Mechanisms and Treatments
- Biomedical and Engineering Education
- Fermentation and Sensory Analysis
- Amphibian and Reptile Biology
- Essential Oils and Antimicrobial Activity
- Legume Nitrogen Fixing Symbiosis
- Phytochemicals and Antioxidant Activities
Princeton University
2020-2025
Texas Tech University
2017-2024
National Center for Biotechnology Information
2019-2021
National Institutes of Health
2019-2021
Yogurt is considered a nutritional, healthy dairy product that highly consumed worldwide produced via milk fermentation. The production process involves standard starter culture of lactic acid bacteria, such as Streptococcus thermophilus and Lactobacillus delbrueckii subsbulgaricus are essential for acidification consequently yogurt flavor generation. Different source combinations, supplementary probiotic cultures, additives nowadays used to enhance composition improve its consumer...
Emerging evidence suggests that the gut microbiome plays an important role in pathophysiology of both obesity and type 2 diabetes mellitus. We previously reported dietary annatto-extracted tocotrienol exerts beneficial effects by modulating inflammatory responses mice fed a high-fat diet (HFD). The purpose this study was to test hypothesis supplementation when combined with HFD would result altered microbiota composition. For 14 weeks, forty-eight male C57BL/6J were assigned 4 groups-low-fat...
Objective: A pre/post pilot study was designed to investigate neurobiological mechanisms and plasma metabolites in an 8-week Tai-Chi (TC) group intervention subjects with knee osteoarthritis. Methods: Twelve postmenopausal women underwent exercise for 8 weeks (60 min/session, three times/week). Outcomes were measured before after Tai Chi including pain intensity (VAS), Brief Pain Inventory (BPI), Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), (amino acids lipids), as...
Abstract Changes in the gut microbiome have been associated with several human diseases, but molecular and functional details underlying these associations remain largely unknown. Here, we performed a multi-cohort analysis of small molecule biosynthetic gene clusters (BGCs) 5,306 metagenomic samples from 2,033 Inflammatory Bowel Disease (IBD) patients 833 matched healthy subjects identified group Clostridia-derived BGCs that are significantly IBD. Using synthetic biology, discovered solved...
Despite evidence linking the gut microbiome to neuropathic pain (NP), it is not known if altering microbiota can alleviate NP via microbiome-gut-brain axis. This study examined healthy of sham male rats (Sham+V) and dysbiotic (spinal nerve ligation: NP, SNL+V) be disrupted restored, respectively, fecal transplant (FMT) from opposite group [Sham+(SNL-FMT) SNL+(Sham-FMT), respectively]. All groups received FMT daily for two weeks, followed by three weeks without FMT. SNL showed higher...
Neuroinflammation and mitochondrial dysfunction have been implicated in the progression of neuropathic pain (NP) but can be mitigated by supplementation with gingerol-enriched ginger (GEG). However, exact benefits GEG for each sex treating neuroinflammation homeostasis different brain regions colon remain to determined.
Characterizing the gut microbiota in terms of their capacity to interfere with drug metabolism is necessary achieve efficacy and safety. Although examples drug-microbiome interactions are well-documented, little has been reported about a computational pipeline for systematically identifying characterizing bacterial enzymes that process particular classes drugs. The goal our study develop approach compiles drugs whose may be influenced by class microbial quantifies variability collective...
Flavors profiling in flavored hookah tobacco is an issue of increasing scrutiny for the health sector owing to its adverse effects on humans, especially being heated produce smoke. This study aims at tackling components involved from a chemical and biological point view. Detecting individual flavor compounds, within complex matrix was accomplished using headspace solid phase microextraction (SPME). A total 114 volatiles were identified 13 products, with esters amounting major component up...
Abstract Previous studies have shown that the Ancient Egyptians used malted wheat and barley as main ingredients in beer brewing, but chemical determination of exact recipe is still lacking. To investigate constituents ancient beer, we conducted a detailed IR GC-MS based metabolite analyses targeting volatile non-volatile metabolites on residues recovered from interior vats what currently world’s oldest (c. 3600 BCE) installation for large-scale production located at major pre-pharaonic...
Microorganisms are diverse in their genome sequences and subsequently encoded metabolic pathways, which enabled them to adapt numerous environmental conditions. They produce thousands of small molecules, many volatiles nature play important roles signaling intra- inter-species kingdom domain interactions, survival, or virulence. Many these compounds have been studied, characterized, organized the mVOC 2.0 database. However, such dataset has not investigated comprehensively terms its...
Geranylgeraniol (GGOH) is found in edible oils such as olive, linseed, and sunflower oils, which have favorable metabolic effects. However, it unknown whether these physiological benefits are mediated through the gut microbiome. Thus, purpose of this study was to test hypothesis that GGOH supplementation would improve glucose homeostasis benefit bone microstructure obese mice suppression inflammation modification microbiota composition. Thirty-six male C57BL/6J were divided into 3 groups: a...
Tai Chi (TC) controls pain through mind-body exercise and appears to alter inflammatory mediators. TC actions on lipid biomarkers associated with inflammation brain neural networks in women knee osteoarthritic were investigated.A single-center, pre- post-TC group (baseline 8 wk) pilot study postmenopausal was performed. 12 eligible participated exercise. The primary outcome liquid chromatography tandem mass spectrometry determination of circulating endocannabinoids (eCB) oxylipins (OxL)....
Microbiome projects are currently booming around the globe, enabled by advances in culture-independent microbial community analysis and high-throughput sequencing. One emerging application of microbiome science involves exploring diversity built environments, one unexplored environment is pharmaceutical factory, notably factories producing antibiotics, as they could be enriched antibiotic-resistant microbes. To examine drug factory microbiome, we launched this interdisciplinary...
Trauma patients (TPs) are highly susceptible to infections, which often lead sepsis. Among the numerous causative agents, Pseudomonas aeruginosa is especially important, as P. sepsis fatal. Understanding mechanism of its pathogenesis in bloodstream infections imperative; however, this has not been previously described. To examine effect trauma-induced changes blood on expression genes, we grew strain UCBPP-PA14 (PA14) samples from eight TPs and seven healthy volunteers (HVs). Compared with...