A5100634799- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Multiple Myeloma Research and Treatments
- HIV Research and Treatment
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Immune cells in cancer
- Celiac Disease Research and Management
- Sperm and Testicular Function
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Renal Transplantation Outcomes and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Mycobacterium research and diagnosis
- Microscopic Colitis
- Complement system in diseases
- vaccines and immunoinformatics approaches
- Protein Degradation and Inhibitors
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Leprosy Research and Treatment
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Ophthalmology and Visual Impairment Studies
- CRISPR and Genetic Engineering
All India Institute of Medical Sciences Raipur
2014-2024
All India Institute of Medical Sciences Bhopal
2014-2024
All India Institute of Medical Sciences
2015-2024
Christian Medical College
2011-2024
DR. B.R.A. Institute Rotary Cancer Hospital
2012-2024
Christian Medical College & Hospital
2011-2024
Maharishi Markandeshwar University, Mullana
2023-2024
Texas Tech University Health Sciences Center
2013-2023
Texas Tech University
2013-2023
Robert Bosch (Germany)
2023
Cell lines are often used in place of primary cells to study biological processes. However, care must be taken when interpreting the results as cell do not always accurately replicate cells. In this article, we will briefly talk about advantages and disadvantages then discuss using mouse Sertoli line, MSC-1, compared with MSC-1 resemble morphologically possess several biochemical markers associated Studies have demonstrated that function regulation retinoic acid receptor α (RARα) is similar...
Objectives: Although celiac disease (CeD) affects 1% of people in the northern part India, it is believed to be uncommon southern and northeastern parts because significant differences dietary pattern ethnicity. We estimated prevalence CeD these three populations. In a subset, we also investigated HLA-DQ 2/8 allelotype grain consumption. Methods: A total 23,331 healthy adults were sampled from regions India—northern (n=6207), (n=8149), (n=8973)—and screened for using IgA anti-tissue...
Recent studies on celiac disease (CeD) have reported alterations in the gut microbiome. Whether this alteration microbial community is cause or effect of not well understood, especially adult onset disease. The first-degree relatives (FDRs) CeD patients may provide an opportunity to study microbiome pre-disease state as FDRs are genetically susceptible CeD. By using 16S rRNA gene sequencing, we observed that ecosystem level diversity measures were significantly different between condition...
Context: Screening for ocular manifestations of leukemia, although not a routine practice, is important as they may antedate systemic disease or form an isolated focus its relapse. Aims: This study evaluates the spectrum in acute and chronic leukemias presenting to tertiary care center India. Settings Design: Subjects leukemia Methods: A prospective, cross-sectional looking at all inpatients leukemia. Statistical Analysis Used: The collected data were analyzed using Package Social Sciences...
Emerging evidence suggests that the gut microbiome plays an important role in pathophysiology of both obesity and type 2 diabetes mellitus. We previously reported dietary annatto-extracted tocotrienol exerts beneficial effects by modulating inflammatory responses mice fed a high-fat diet (HFD). The purpose this study was to test hypothesis supplementation when combined with HFD would result altered microbiota composition. For 14 weeks, forty-eight male C57BL/6J were assigned 4 groups-low-fat...
Genetic polymorphisms in Toll-like receptor 4, TLR4 896 A/G (Asp299Gly) and 1196 C/T (Thr399Ile) have been reported to influence function the innate host immune response mycobacteria. We investigated effect of these single nucleotide on susceptibility severity pulmonary tuberculosis (PTB) Asian Indian population. A significantly increased frequency Asp299Gly mutation was observed patient group (17%) as compared with healthy controls [8.8%, chi(2) = 10.7, P 0.001,odds ratio (OR ) 2.1]. On...
Early detection and treatment of vision problems in children is imperative to meet the challenges childhood blindness. Considering inequitable distribution trained manpower limited access quality eye care services majority our population, innovative community based strategies like 'Teachers training screening' need be developed for effective utilization available human resources.To evaluate effectiveness introducing teachers as first level screeners.Teacher programs were conducted school...
Human immunodeficiency virus type 1 (HIV-1)-infected T cells form a virological synapse with noninfected CD4(+) in order to efficiently transfer HIV-1 virions from cell cell. The is specialized cellular junction that similar some respects the immunological involved T-cell activation and effector functions mediated by antigen receptor. stops migration allow sustained interaction between T-cells antigen-presenting cells. Here, we have asked whether envelope gp120 presented on surface mimic an...
Abstract There is a great range in outcomes after mycobacterial infections, and this probably due to individual variation immune responses. One of the key cytokine regulators response interleukin (IL‐) 12. The IL12B gene encodes p40 chain both IL‐12 IL‐23 it has two major variant sites at which different alleles are associated with increased levels expression susceptibility immune‐related diseases. We hypothesized that variants would be as persistent infection. tested hypothesis by...
Diabetes is a risk factor for osteoporosis. Annatto-extracted tocotrienols (TT) have proven benefits in preserving bone matrix. Here, we evaluated the effects of dietary TT on glucose homeostasis, properties, and liver pro-inflammatory mRNA expression high-fat diet (HFD)-induced type 2 diabetic (T2DM) mice. 58 male C57BL/6 J mice were divided into 5 groups: low-fat (LFD), HFD, HFD + 400 mgTT/kg (T400), 1600 (T1600), 200 mg metformin/kg (Met) 14 weeks. Relative to group, both TT-supplemented...
Abstract Polymorphisms located within the MHC have been linked to many disease outcomes by mechanisms not yet fully understood in most cases. Variants untranslated regions of HLA genes are involved allele-specific expression and may therefore underlie some these associations. We determined sequences extending nearly 2 kb upstream transcription start site for 68 alleles from 57 major lineages classical class I genes. The nucleotide diversity this promoter segment roughly follows that seen...
Abstract Abnormal expression patterns of regulatory small non-coding RNA (sncRNA) molecules such as microRNAs (miRs), piwi-interacting RNAs (piRNAs), and nucleolar (snoRNAs) play an important role in the development progression cancer. Identification clinically relevant sncRNA signatures could, therefore, be tremendous translational value. In present study, genome-wide sequencing identified a unique pattern differential regulation eight miRs Chronic Lymphocytic Leukemia (CLL). Among these,...