A5100605400- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- HIV Research and Treatment
- Celiac Disease Research and Management
- Mycobacterium research and diagnosis
- Complement system in diseases
- Anesthesia and Pain Management
- Diabetes Management and Research
- Biological Activity of Diterpenoids and Biflavonoids
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
- Congenital Heart Disease Studies
- interferon and immune responses
- South Asian Cinema and Culture
- Nausea and vomiting management
- Cardiac Valve Diseases and Treatments
- Immunodeficiency and Autoimmune Disorders
- Natural Antidiabetic Agents Studies
- Phytochemical compounds biological activities
- Liver Diseases and Immunity
- Infection Control and Ventilation
- Hematopoietic Stem Cell Transplantation
- Herbal Medicine Research Studies
All India Institute of Medical Sciences
2009-2024
National Institute of Pathology
2021-2024
Magadh University
2024
Safdarjang Hospital
2021-2023
Indian Council of Medical Research
2021-2023
Galgotias University
2023
Dr. Rajendra Prasad Government Medical College
2020
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2020
Madurai Medical College
2018
Government Medical College and Hospital
2014
We undertook a randomised, double-blind, placebo-controlled study to compare the analgesic efficacy of pre-operative stellate ganglion block on postoperative pain relief after upper limb orthopaedic surgery. Patients were administered 3-ml injection during ultrasound-guided block; 15 patients received lidocaine 2% and 0.9% saline. Following block, all standardised general anaesthesia. Postoperative analgesia included regular intravenous diclofenac, paracetamol patient-controlled with...
Abstract There is a great range in outcomes after mycobacterial infections, and this probably due to individual variation immune responses. One of the key cytokine regulators response interleukin (IL‐) 12. The IL12B gene encodes p40 chain both IL‐12 IL‐23 it has two major variant sites at which different alleles are associated with increased levels expression susceptibility immune‐related diseases. We hypothesized that variants would be as persistent infection. tested hypothesis by...
Abstract The allelic and genotype frequencies corresponding to 22 single nucleotide polymorphisms (SNPs) in 13 cytokine genes interleukin (IL) 1‐α (T/C −889), IL1‐β (C/T −511, T/C +3962), IL12 (C/A −1188), interferon‐γ (A/T UTR 5644), transforming growth factor‐β codon 10, G/C 25), tumour necrosis factor‐α (G/A −308, G/A −238), IL2 (T/G −330, G/T +160), IL4 −1098, −590, −33), IL6 (G/C −174, nt 565), IL10 −1082, C/T −819, C/A −592), IL1R pst11970), IL1RA mspa111100) IL4RA +1902) were...
Abstract Microsatellite polymorphism in exon 5 of major histocompatibility complex class I chain related gene‐A ( MIC ‐A) has been implicated the etiology autoimmune diseases including type 1 diabetes T1D ) and celiac disease CD ). In this study on North Indian population, MIC‐A5 .1 allele, carrying a premature termination codon transmembrane region, was observed with increased frequency (29.6%, odds ratio OR = 2.1, P 0.00017) patients (40.3%, 3.37, 1. 67E ‐05) than controls (16.7%). When...
Abstract Background Type 1 diabetes (T1D) is a complex disease, with involvement of various susceptibility genes. Human leukocyte antigen (HLA) on chromosome 6p21 major region. This study examined genetic association HLA genes T1D. Methods The recruited 259 T1D patients and 706 controls from north India. PCR‐SSP LiPA were used to type Class I II alleles. Results At locus, HLA‐A*02, A*26, B*08 B*50 significantly increased in vs (39.8% 28.9% [Bonferroni‐corrected P { c } = 0.032], 24.7% 9.6% [...
We planned this study to identify diabetogenic glutamic acid decarboxylase (GAD65) peptides possibly responsible for human leucocyte antigen (HLA)-DR3/DQ2-mediated activation of GAD65-specific CD4 T cells in type 1 diabetes (T1D).Top 30 GAD65 peptides, found strongly bind silico with HLA-DR3/DQ2 molecules, were selected and grouped into four pools. The used stimulate subjects 16-h peripheral blood mononuclear cell culture. cells' stimulation terms interferon-gamma (IFN-γ), interleukin...
Summary Substitution of V64I in CCR2 relates to delayed progression AIDS and protects against HIV‐1 infection. We examined the distribution HIV‐infected healthy North Indian subjects. No significant difference allele or genotype polymorphism was observed, indicating that there is no association between susceptibility HIV infection population.
We have defined three sets of HLA‐DR3 + haplotypes that provide maximum risk type 1 disease development in Indians: (1) a diverse array B8‐DR3 haplotypes, (2) A33‐B58‐DR3 haplotype, and (3) A2‐B50‐DR3 occurring most predominantly this population. Further analysis has revealed extensive diversity particularly at the HLA‐A locus, contrast to single fixed HLA‐A1‐B8‐DR3 haplotype (generally referred as AH8.1) reported Caucasians. However, classical AH8.1 was rare differed from Caucasian...
Selection of an HLA identical donor is a critical pre-requisite for successful hematopoietic stem cell transplantation (HSCT). Most transplant centers utilize blood as the most common source DNA testing. However, obtaining through phlebotomy often challenging in patients with conditions like severe leucopenia or hemophilia, pediatric and elderly patients. We have used simple in-house protocol shown that genotypes obtained on extracted from saliva hair are concordant hence can be selection...
Summary A nonsynonymous SNP +1858 C / T (rs2476601) in the protein tyrosine phosphatase, nonreceptor type 22( PTPN 22) gene leading to rg 620 rp substitution is known be associated with susceptibility 1 diabetes ( D ) and several other autoimmune diseases. We studied this polymorphism 145 patients 210 healthy controls from N orth I ndia. The minor allele was observed significantly increased among as compared (2.76% vs 0.5%, P = 0.027, OR 5.93; 95% CI 1.4–24.8). association also at level of...
Summary Objectives Autoimmune thyroid diseases (AITD) encompass a number of conditions that have in common cellular and humoral responses targeting the gland. Interactions between susceptibility genes environmental triggers are thought to initiate an autoimmune response antigens leading disease manifestation. Commencement childhood leads presumption genetics may important role causation disease. Design The present study was aimed at evaluating human leucocyte antigen (HLA) encoded develop...
Type 1 diabetes (T1D) is a polygenic autoimmune disease. Susceptibility to T1D strongly linked major genetic locus that the MHC, and several other minor loci including insulin, cytotoxic T-lymphocyte-associated antigen-4, PTPN22 others contribute risk in an epistatic way. We have observed there are three sets of DR3-positive autoimmunity-favoring haplotypes north-Indian population, B50-DR3, B58-DR3 B8-DR3. The classical Caucasian autoimmunity favoring AH8.1 (HLA-A1-B8-DR3) rare Indian has...