A5010756691- Celiac Disease Research and Management
- Microscopic Colitis
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- Digestive system and related health
- Clinical Nutrition and Gastroenterology
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal disorders and treatments
- IL-33, ST2, and ILC Pathways
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Probiotics and Fermented Foods
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Intestinal Malrotation and Obstruction Disorders
Inserm
2016-2025
Université Paris Cité
2016-2025
Institut des Maladies Génétiques Imagine
2016-2025
Assistance Publique – Hôpitaux de Paris
2006-2024
Hôpital Cochin
2024
Infection et inflammation
2022
Immunité et Cancer
2014-2021
Délégation Paris 5
2011-2020
Sorbonne Paris Cité
2011-2020
Hôpital Necker-Enfants Malades
1999-2019
The Microbiota Makes for Good Therapy gut microbiota has been implicated in the development of some cancers, such as colorectal cancer, but—given important role our intestinal habitants play metabolism—they may also modulate efficacy certain cancer therapeutics. Iida et al. (p. 967 ) evaluated impact on an immunotherapy [CpG (the cytosine, guanosine, phosphodiester link) oligonucleotides] and oxaliplatin, a platinum compound used chemotherapeutic. Both therapies were reduced tumor-bearing...
Gut microbes make T cells keep the peace Our guts harbor trillions of microbial inhabitants, some which regulate types immune that are present in gut. For instance, Clostridium species bacteria induce a type cell promotes tolerance between host and its contents. Ohnmacht et al. Sefik characterized population gut regulatory mice, required microbiota to survive. Multiple bacterial could transcription factor–expressing helped maintain homeostasis. Mice engineered lack these factors exhibited...
Mouse gut intraepithelial lymphocytes (IEL) consist mainly (90%) of two populations CD8+ T cells. One bears heterodimeric alpha/beta CD8 chains (Lyt-2+, Lyt-3+), a cell receptor (TCR) made chains, and is Thy-1+; it represents the progeny blasts elicited in Peyer's patches by antigenic stimulation. The other homodimeric alpha/alpha contains no beta chain mRNA, mostly Thy-1- TCR-gamma/delta + or -alpha/beta +; thymo-independent does not require stimulation, as shown its presence: (a) nude scid...
Abstract A monoclonal antibody, HML‐1, was produced by fusion of NSI myeloma cells with spleen a mouse immunized isolated human intestinal intraepithelial lymphocytes (IEL). Immunofluorescence studies cells, as well immunoperoxidase staining tissue sections, indicated that HML‐1 labeled all the various subsets IEL, approximately 40% lamina propria T 30% mesenteric lymphoblasts and some in other mucosae, particularly IEL. Conversely, it revealed only rare lymphoid compartments. Analysis...
ABSTRACT Recent data have shown that Eps15, a newly identified component of clathrin-coated pits constitutively associated with the AP-2 complex, is required for receptor-mediated endocytosis. However, its precise function remains unknown. Interestingly, Eps15 contains three EH (Eps15-Homology) domains also found in proteins internalization step endocytosis yeast. Results presented here show are correct coated pit targeting Eps15. Furthermore, when cells expressed an mutant lacking domains,...
OBJECTIVES: The enteropathy associated with common variable immunodeficiency (CVID) is poorly characterized, and its possible relationships well-defined causes of enteropathy, such as celiac sprue (CS), remain debated. We aimed to assess the clinical histopathological features CVID. METHODS: medical files 50 CVID patients gastrointestinal symptoms were analyzed retrospectively. Histological, phenotypic, molecular analysis intestinal endoscopic specimens was centrally performed. RESULTS:...
OBJECTIVES: Early onset inflammatory bowel diseases (EO-IBD) developing during the first year of life are likely to reflect inherited defects in key mechanism(s) controlling intestinal homeostasis, as recently suggested for interleukin 10 (IL10). Thus, we aimed further elaborate hypothesis defective anti-inflammatory responses patients with IBD. METHODS: The capacities transforming growth factor β (TGFβ) and IL10 inhibit proinflammatory cytokine production by monocyte-derived dendritic cells...
Background Recently, a new enteropathy has been described: olmesartan-associated enteropathy. However, the association questioned: phase 3 trial and cohort study found no between gastrointestinal events olmesartan. Aim To collect French cases of sartan-associated to describe further this entity, confirm or refute causality, determine if exists with other sartans. Methods gastroenterologists were invited report clinical, biological histological data. Patients diarrhoea duodenal abnormalities...
Abstract Individuals differ widely in their immune responses, with age, sex and genetic factors having major roles this inherent variability 1–6 . However, the variables that drive such differences cytokine secretion—a crucial component of host response to challenges—remain poorly defined. Here we investigated 136 identified smoking, cytomegalovirus latent infection body mass index as contributors response, effects comparable magnitudes genetics. We find smoking influences both innate...
We have previously shown that the protein Eps15 is constitutively associated with plasma membrane adaptor complex, AP-2, suggesting its possible role in endocytosis. To explore of and function AP-2/Eps15 association endocytosis, binding domain for AP-2 was precisely delineated. The entire COOH-terminal or a mutant form lacking all AP-2–binding sites fused to green fluorescent (GFP), these constructs were transiently transfected HeLa cells. Overexpression fusion containing strongly inhibited...