A5038408948- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Trace Elements in Health
- Viral-associated cancers and disorders
- Magnesium in Health and Disease
- Gut microbiota and health
- Protein Interaction Studies and Fluorescence Analysis
- Drug Transport and Resistance Mechanisms
- Immunotherapy and Immune Responses
- Hemoglobin structure and function
- Parvovirus B19 Infection Studies
- Carcinogens and Genotoxicity Assessment
- Parathyroid Disorders and Treatments
- Diabetes Treatment and Management
- Potassium and Related Disorders
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Lanthanide and Transition Metal Complexes
- Plant Micronutrient Interactions and Effects
- Blood properties and coagulation
- Lymphoma Diagnosis and Treatment
- DNA and Nucleic Acid Chemistry
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
University of St Andrews
2019-2025
Institut Necker Enfants Malades
2014-2023
Université Paris Cité
2014-2023
Inserm
2014-2023
Centre National de la Recherche Scientifique
2023
Délégation Paris 5
2014-2018
Sorbonne Paris Cité
2014-2018
University of Freiburg
1992
Marginal zone (MZ) B cells are one of the main actors T-independent (TI) responses in mice. To identify cell subset(s) involved such humans, we vaccinated healthy individuals with Pneumovax, a model TI vaccine. By high-throughput repertoire sequencing plasma (PCs) isolated 7 days after vaccination and different subpopulations before vaccination, show that PC response mobilizes large clones systematically, including an immunoglobulin M component, whose diversification amplification predated...
Serum albumin–Co2+ interactions are of clinical importance. They play a role in mediating the physiological effects associated with cobalt toxicity and central to albumin binding (ACB) assay for diagnosis myocardial ischemia. To further understand these processes, deeper understanding is required. Here, we present first crystallographic structures human serum (HSA; three structures) equine (ESA; one structure) complex Co2+. Amongst total sixteen sites bearing ion across structures, two...
To what extent immune responses against the gut flora are compartmentalized within mucosal tissues in homeostatic conditions remains a much-debated issue. We describe here, based on an inducible AID fate-mapping mouse model, that systemic memory B cell subsets, including mainly IgM+ cells spleen, together with IgA+ plasma spleen and bone marrow, generated mice absence of deliberate immunization. While IgA component appears dependent flora, IgM still germ-free mice, albeit to reduced extent....
Background/Objectives: Cardiovascular diseases (CVDs) are the leading cause of global mortality. Major adverse cardiovascular events (MACEs)-such as acute myocardial infarction, stroke, and heart failure-are critical endpoints in clinical research. The existing research has shown metal ions important regulators functioning, defective handling may be associated with an increased risk CVD. This study examines association plasma/serum levels magnesium, copper, zinc MACE incidence prevalence...
The opening of a Watson–Crick double helix is required for crucial cellular processes, including replication, repair, and transcription. It has long been assumed that RNA or DNA base pairs are broken by the concerted symmetric movement complementary nucleobases. By analyzing thousands base-pair closing events from molecular simulations, here, we uncover systematic stepwise process driven asymmetric flipping-out probability paired We demonstrate experimentally such asymmetry strongly biases...
A main feature of Wiskott-Aldrich syndrome (WAS) is increased susceptibility to autoimmunity. key contribution B cells development these complications has been demonstrated through studies samples from affected individuals and mouse models the disease, but role WAS protein (WASp) in controlling peripheral tolerance not specifically explored. Here we show that cell responses remain T dependent constitutive WASp-deficient mice, whereas selective WASp deletion germinal center (GCBs) sufficient...
The foetal plasma protein alpha-fetoprotein harbours a strong Zn 2+ binding site ( K D = 1.9 × 10 −8 M), supporting the hypothesis of role in zinc homeostasis.