A5057781536- Complement system in diseases
- Blood groups and transfusion
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- T-cell and B-cell Immunology
- Vitamin K Research Studies
- Genomic variations and chromosomal abnormalities
- Sexual Differentiation and Disorders
- Erythrocyte Function and Pathophysiology
- Adenosine and Purinergic Signaling
- Neurotransmitter Receptor Influence on Behavior
- Genetic Associations and Epidemiology
- Iron Metabolism and Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Hemoglobinopathies and Related Disorders
- Metabolism and Genetic Disorders
- SARS-CoV-2 and COVID-19 Research
- Amino Acid Enzymes and Metabolism
- Congenital heart defects research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Mast cells and histamine
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
Semmelweis University
2016-2025
Hungarian Academy of Sciences
2009-2023
National Center for Spinal Disorders
1983-2018
Buda Health Center
2016
Universität Innsbruck
2007
University of Veterinary Medicine
1997
Institute of Psychiatry and Neurology
1993
Universitäts Frauenklinik
1992
Universität Ulm
1992
Catastrophic antiphospholipid syndrome (CAPS) is a rare but devastating complication in patients with (APS) high morbidity and mortality.We describe case of 30-year old female patient immunoglobulin A (IgA) deficiency who underwent splenectomy because idiopathic thrombocytopenic thrombocytopenia. Subsequently, an APS finally systemic lupus erythematosus was diagnosed. After uncomplicated pregnancy that terminated by cesarean section, the developed severe CAPS cerebral, myocardial, renal,...
Abstract Background The fourth component of human complement (C4), an essential factor the innate immunity, is represented as two isoforms (C4A and C4B) in genome. Although these genes differ only 5 nucleotides, encoded C4A C4B proteins are functionally different. Based on phenotypic determination, unbalanced production associated with several diseases, such systemic lupus erythematosus, type 1 diabetes, autoimmune moreover higher morbidity mortality myocardial infarction increased...
Complement component C4 is a central protein in the classical and lectin pathways within complement system. During activation of complement, its major fragment C4b becomes covalently attached to surface pathogens altered self-tissue, where it acts as an opsonin marking for removal. Moreover, provides platform assembly proteolytically active convertases that mediate downstream by cleavage C3 C5. In this article, we present crystal solution structures 195-kDa C4b. Our results provide molecular...
BackgroundAtypical forms of haemolytic uraemic syndrome (aHUS) include HUS caused by defects in the regulation alternative complement pathway and linked to neuraminidase-producing pathogens, such as Streptococcus pneumoniae. Increasing data support a pathogenic role neuraminidase development S. pneumoniae-associated (SP-HUS), but has never been clarified detail. Therefore, we aimed investigate whether pathologic profile genetic risk factors aHUS are present patients with SP-HUS.
Heroin dependence is a debilitating psychiatric disorder with complex inheritance. Since the dopaminergic system has key role in rewarding mechanism of brain, which directly or indirectly targeted by most drugs abuse, we focus on effects and interactions among gene variants.
Atypical HUS (aHUS) is a disorder most commonly caused by inherited defects of the alternative pathway complement, or proteins that regulate this pathway, and life-threatening episodes aHUS can be provoked pregnancy. We retrospectively prospectively investigated 27 maternal fetal pregnancy outcomes in 14 women with from Vienna Thrombotic Microangiopathy Cohort. Seven pregnancies (26%) were complicated pregnancy-associated (p-aHUS), which three appeared to infection, bleeding, curettage,...
Abstract Introduction Activation of inflammation and coagulation are closely related mutually interdependent in sepsis. The acute-phase protein, plasminogen activator inhibitor-1 (PAI-1) is a key element the inhibition fibrinolysis. Elevated levels PAI-1 have been to worse outcome pneumonia. We aimed evaluate effect functionally relevant 4G/5G polymorphism gene pneumonia induced Methods enrolled 208 Caucasian patients with severe sepsis due admitted an intensive care unit (ICU). Patients...
Introduction While complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three pathways might be activated by the virus. Lectin pathway activation occurs through different pattern recognition molecules, including mannan binding lectin (MBL), protein shown interact with SARS-CoV-2 proteins. However, exact role of and its key molecule MBL COVID-19 still not fully understood. Methods We therefore investigated two...
Abstract The factors influencing the heterogeneous clinical manifestation of hereditary angioedema due to C1‐ INH deficiency (C1‐ ‐ HAE ) represent one oldest unsolved problems disease. Considering that factor XII ( FXII levels may affect bradykinin production, we investigated contribution functional promoter polymorphism F12 ‐46C/T in disease phenotype. We studied 258 patients from 113 European families, and explored possible associations with features SERPING 1 mutational status. Given our...
Background: Membranoproliferative glomerulonephritis (MPGN) is an umbrella term for chronic disorders affecting the glomeruli. MPGN often accompanied by presence of autoantibodies against complement components. However, actual pathogenic effects such autoantibodies, if any, are rarely studied. In this work, we investigated role anti-complement in IC-MPGN patient. Methods: The their binding site, isotype, and titer were analyzed ELISA. Antibody–antigen complexes detected patient’s serum using...
Atypical hemolytic uremic syndrome (aHUS), also called complement-mediated (CM-HUS), is a rare disease caused by dysregulation in the alternative complement activation pathway. It life-threatening condition causing ischemia of number organs, and it typically causes acute kidney injury. This disorder may be triggered various factors including viral or bacterial infections, pregnancy, surgery, injuries. In about 60% cases, genetic origin can identified—commonly mutations affecting...
Vitamin D receptor (VDR) is an important candidate gene in muscle function. Scientific reports on the effect of its genetic variants strength are contradictory likely due to inconsistent study designs. Hand grip (HGS) a highly heritable phenotype but only limited studies available background. Association between VDR polymorphisms and HGS has been poorly investigated previous conflicting. We studied sample 706 schoolchildren. Genomic DNA was extracted from saliva samples six single nucleotide...
Background.—The serotonin transporter gene is a promising candidate locus for the genetic susceptibility of migraine. Objective.—Two functional polymorphisms (5‐HTTLPR and STin2) were analyzed to assess whether these variants are associated with pediatric Methods.—Eighty‐seven Hungarian migraine patients 464 controls genotyped using polymerase chain reaction. Patients suffering from (n = 38) or without aura 49) interviewed regarding clinical symptoms before during attacks. Results.—There was...
Background: The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying deficiency ADAMTS13 protease caused by autoantibodies, predominantly IgG isotype. Certain HLA-DR-DQ haplotypes were associated with risk developing TTP. Objectives: To investigate development ADAMTS13-specific antibody response during course we analyzed concentration, subclass distribution, and inhibitory potential anti-ADAMTS13 autoantibodies samples TTP...
Introduction As the global pandemic continues, new complications of COVID-19 in pediatric population have turned up, one them being hemolytic uremic syndrome (HUS), a complement-mediated thrombotic microangiopathy (CM-TMA) characterized by triad thrombocytopenia, microangiopathic anemia and acute kidney injury (AKI). With both multisystem inflammatory children (MIS-C) HUS sharing complement dysregulation as key factors, aim this case report is to highlight differences between these two...