Fotis Psarros
A5018159250- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Vitamin K Research Studies
- Autoimmune Bullous Skin Diseases
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Peptidase Inhibition and Analysis
- Hemophilia Treatment and Research
- Mast cells and histamine
- Food Allergy and Anaphylaxis Research
- Effects of Radiation Exposure
- Blood Coagulation and Thrombosis Mechanisms
- IL-33, ST2, and ILC Pathways
- Nasal Surgery and Airway Studies
- Oil Spill Detection and Mitigation
- Global Healthcare and Medical Tourism
- Enzyme function and inhibition
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Coastal and Marine Dynamics
- QR Code Applications and Technologies
- Data-Driven Disease Surveillance
- Contact Dermatitis and Allergies
- Health and Medical Studies
Athens Naval & Veterans Hospital
2015-2025
Charité - Universitätsmedizin Berlin
2024
Humboldt-Universität zu Berlin
2024
Semmelweis University
2024
Goethe University Frankfurt
2024
University Hospital Frankfurt
2024
Sotiria General Hospital
2012
National and Kapodistrian University of Athens
2004
Athens State University
2003
Approved on-demand treatments for hereditary angioedema attacks need to be administered parenterally, a route of administration that is associated with delays in treatment or withholding therapy.
<h2>Abstract</h2><h3>Background</h3> Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) causes swelling in the skin and upper airways pain abdomen because of mucosal swelling. C1-INH-HAE is frequently misdiagnosed, leading delays diagnosis, inadequate treatment, unnecessary procedures. <h3>Objective</h3> To evaluate history misdiagnosis patients participating Icatibant Outcome Survey (IOS). <h3>Methods</h3> The IOS an observational study which safety effectiveness icatibant...
Pollen allergy poses a significant health and economic burden in Europe. Disease patterns are relatively homogeneous within Central Northern European countries. However, no study broadly assessed the features of seasonal allergic rhinitis (SAR) across different Southern countries with standardized approach.
Abstract The factors influencing the heterogeneous clinical manifestation of hereditary angioedema due to C1‐ INH deficiency (C1‐ ‐ HAE ) represent one oldest unsolved problems disease. Considering that factor XII ( FXII levels may affect bradykinin production, we investigated contribution functional promoter polymorphism F12 ‐46C/T in disease phenotype. We studied 258 patients from 113 European families, and explored possible associations with features SERPING 1 mutational status. Given our...
Collecting data on the localization of users is a key issue for MASK (Mobile Airways Sentinel networK: Allergy Diary) App. Data anonymization method sanitization privacy. The European Commission's Article 29 Working Party stated that geolocation information personal data.To assess using and to compare two methods in database find an optimal privacy method.Geolocation was studied all people who used Diary App from December 2015 November 2017 reported medical outcomes. Two different have been...
Abstract Background Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This especially relevant in geographic areas with broad spectrum of pollen sensitization, such as Southern Europe. Objectives To elucidate similarities differences PFAS nine European centers identify associated characteristics unique markers PFAS. Methods As part the @IT.2020 Multicenter Study, 815 patients seasonal allergic...
Summary Background Immune responses to rhinovirus (RV) as well direct effects of RV on respiratory epithelium may contribute the induction asthma exacerbations. Objective To evaluate effect environment resulting from an atopic immune response RV‐induced epithelial inflammation, replication and cytotoxicity. Methods Peripheral blood mononuclear cells (PBMC) asthmatic subjects matched controls (12 pairs) were isolated stimulated by RVs. Human bronchial (BEAS‐2B) infected with in presence...
<b><i>Background:</i></b> In view of the large heterogeneity in clinical presentation hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE), great efforts are being made towards detecting measurable biological determinants disease severity that can help improve management disease. Considering central role plasma kallikrein plays bradykinin production, we investigated contribution functional polymorphism <i>KLKB1</i>-428G/A phenotype....
The adequate definition of pollen seasons is essential to facilitate a correct diagnosis, treatment choice, and outcome assessment in patients with seasonal allergic rhinitis. A position paper by the European Academy Allergy Clinical Immunology (EAACI) proposed season definitions for Northern Middle Europe.To test EAACI six Mediterranean cities seven taxa.As part @IT.2020 multi-center study, counts Poaceae, Oleaceae, Fagales, Cupressaceae, Urticaceae (Parietaria spp.), Compositae (Ambrosia...
<b><i>Background:</i></b> No published data presently exist concerning hereditary angioedema (HAE) in Greece. The aim of this study was to present the results from patients recorded by Greek Hereditary Angioedema Registry over last 3 years (July 2010 June 2013). <b><i>Methods:</i></b> A systematic recording HAE cases undertaken following a physician awareness campaign and confirmation diagnosis. questionnaire also used for assessment key...
The genetic alteration underlying the great majority of primary angioedema with normal C1 inhibitor (nl-C1-INH-HAE) cases remains unknown. To search for variants associated nl-C1-INH-HAE, we genotyped 133 unrelated nl-C1-INH-HAE patients using a custom next-generation sequencing platform targeting 55 genes possibly involved in pathogenesis. Patients already diagnosed F12 alterations as well those histaminergic acquired were excluded. A variant pathogenicity curation strategy was followed,...
In about 5% of patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) no mutation in the SERPING1 gene is detected. C1-INH-HAE cases coding region after conventional genotyping were examined for defects intronic or untranslated regions gene. Using a next-generation sequencing (NGS) platform targeting entire SERPING1, 14 unrelated detectable mutations sequenced. Detected variants global minor allele frequency lower than (0.002%), submitted silico analysis using ten...
Hereditary angioedema (HAE) is a rare condition, mostly due to genetic deficiency of complement C1 inhibitor (C1-INH). The rarity HAE impedes extensive data collection and assessment the impact certain factors known affect course this disabling life-threatening disease. Establishing global registry could assist overcome such issues provides valuable patient from different countries. Global Registry disease-specific registry, with web-based electronic support, where are provided by physicians...