A5067140555- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Allergic Rhinitis and Sensitization
- Hemophilia Treatment and Research
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Vitamin K Research Studies
- Healthcare and Venom Research
- Enzyme function and inhibition
- PI3K/AKT/mTOR signaling in cancer
- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- Chronic Myeloid Leukemia Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Respiratory and Cough-Related Research
- Hormonal and reproductive studies
- Pharmaceutical studies and practices
- Dermatology and Skin Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Myasthenia Gravis and Thymoma
- Herbal Medicine Research Studies
- Wheat and Barley Genetics and Pathology
- Peptidase Inhibition and Analysis
Jagiellonian University
2015-2024
Semmelweis University
2024
Goethe University Frankfurt
2024
University Hospital Frankfurt
2024
Charité - Universitätsmedizin Berlin
2024
Humboldt-Universität zu Berlin
2024
Ionis Pharmaceuticals (United States)
2024
Collegium Medicum in Bydgoszcz
2014-2018
Nicolaus Copernicus University
2018
Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis effective therapy are critical. This revision update of the global WAO/EAACI guideline on management HAE provides up-to-date guidance HAE. For this guideline, an international panel experts reviewed existing evidence, developed 28 recommendations, established consensus by online DELPHI process. The goal these recommendations to help physicians their patients in making rational decisions with deficient C1...
Approved on-demand treatments for hereditary angioedema attacks need to be administered parenterally, a route of administration that is associated with delays in treatment or withholding therapy.
Hereditary angioedema is a rare disorder characterized by episodic, potentially life-threatening swelling caused kallikrein-kinin dysregulation. Long-term prophylaxis can stabilize this system. Donidalorsen, an antisense oligonucleotide, specifically reduces prekallikrein expression.
Abstract Background Berotralstat (BCX7353) is an oral, once‐daily inhibitor of plasma kallikrein recently approved for prevention angioedema attacks in adults and adolescents with hereditary (HAE). The objective this report to summarize results from interim analysis ongoing long‐term safety study berotralstat patients HAE. Methods APeX‐S ongoing, phase 2, open‐label conducted 22 countries ( ClinicalTrials.gov , NCT03472040). Eligible a clinical diagnosis HAE due C1 deficiency (HAE‐C1‐INH)...
Hereditary angioedema (HAE) caused by a deficiency in functional C1 esterase inhibitor (C1INH) is characterized recurrent episodes of cutaneous and/or mucosal/submucosal tissue swelling affecting multiple anatomic locations. Previous studies demonstrated efficacy recombinant human C1INH (rhC1INH) for acute HAE attacks.This study evaluated the and safety rhC1INH (50 IU/kg) treatment attacks an open-label extension study.Time to onset symptom relief time minimal symptoms were assessed using...
Given the recent approval of oral berotralstat in several countries for hereditary angioedema (HAE) prophylaxis, transition from long-term androgens to may occur clinical practice. The open-label, Phase II APeX-S trial provided an opportunity assess safety and effectiveness patients previously treated with differing durations shorter periods. Therefore, we examined safety, effectiveness, impact on quality life after prior androgen use trial. Alanine aminotransferase (ALT) elevations were...
Venom immunotherapy treatment (VIT) is the only causal of hymenoptera venom anaphylaxis, which aims to provide long-lasting immunoprotection against severe reactions subsequent stings.
Hereditary angioedema (HAE) is a rare inherited autosomal dominant disease caused by deficiency or dysfunction of C1 inhibitor (C1INH). Clinical symptoms include recurrent subcutaneous and submucosal the internal organs. Abdominal attacks affect more than 90% patients, are often misdiagnosed result in unnecessary surgical procedures.To analyse utility imaging studies (USG, CT) patients with C1INH-HAE during an abdominal attack remission.We enrolled 40 type I II HAE (30 women, 10 men; mean...
AMA Obtulowicz P, Stobiecki M, Dyga W, Popiela T, K. Abdominal attack in a patient with hereditary angioedema due to C1 inhibitor deficiency complicated by perforated peptic ulcer. Alergologia Polska - Polish Journal of Allergology. 2024;11(1):80-83. doi:10.5114/pja.2024.135548. APA Obtulowicz, P., Stobiecki, M., Dyga, W., Popiela, T., & (2024). Allergology, 11(1), 80-83. https://doi.org/10.5114/pja.2024.135548 Chicago Piotr, Marcin Wojciech Tadeusz and Krystyna Obtulowicz. 2024. "Abdominal...
Background: Allergen immunotherapy (AIT) is a well-established and efficient method of causative treatment for allergic rhinitis, asthma insect venom allergy. Traditionally, recent history malignant neoplasm regarded as contraindication to AIT due concerns that might stimulate tumor growth. However, there are no data confirming the silencing Th2 response affects prognosis in cancer. Objectives: The aim this study was investigate frequency tumors patients undergoing association between...
Abdominal angioedema attacks are a frequent and typical symptom of hereditary (HAE) but very often generate diagnostic problems. The study presents laboratory clinical findings 7 patients with HAE 1/2 hospitalized due to severe attacks. In all cases, at admittance abdominal pain, flatulence, strong weakness, different grade nausea/vomiting or diarrhoea abundant free fluid in peritoneal cavity were present. the history patients, recurrent 2 3 day long attack ascites, announced. Laboratory...