A5019791448- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemophilia Treatment and Research
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Vitamin K Research Studies
- Mast cells and histamine
- Body Image and Dysmorphia Studies
- Enzyme function and inhibition
- Empathy and Medical Education
- Beetle Biology and Toxicology Studies
- Chronic Myeloid Leukemia Treatments
- Peptidase Inhibition and Analysis
- Dermatology and Skin Diseases
- Tattoo and Body Piercing Complications
- PI3K/AKT/mTOR signaling in cancer
- Blood Coagulation and Thrombosis Mechanisms
- Psoriasis: Treatment and Pathogenesis
- Medicine and Dermatology Studies History
- Pharmaceutical studies and practices
- Acne and Rosacea Treatments and Effects
- Microscopic Colitis
- Complement system in diseases
- Hidradenitis Suppurativa and Treatments
Saints Cyril and Methodius University of Skopje
2014-2024
PHI University Psychiatric Clinic - Skopje
2009-2017
Hereditary angioedema is a life-threatening illness caused by mutations in the gene encoding C1 inhibitor (also called esterase inhibitor) that lead to overactivation of kallikrein-bradykinin cascade. BCX7353 potent oral small-molecule plasma kallikrein with pharmacokinetic and pharmacodynamic profile may help prevent attacks.In this international, three-part, dose-ranging, placebo-controlled trial, we evaluated four doses (62.5 mg, 125 250 350 mg once daily) for prevention attacks over...
Body dysmorphic disorder (BDD) is a common psychiatric associated with high costs for healthcare systems as patients may repeatedly ask different, often not effective, interventions. BDD symptoms are more prevalent in dermatological conditions than the general population, but there no large sample studies comparing prevalence of between and healthy skin controls.
Perceived stigmatization places a large psychosocial burden on patients with some skin conditions. Little is known about the experience of across wide range diseases. This observational cross-sectional study aimed to quantify perceived and identify its predictors among broad spectrum diseases 17 European countries. Self-report questionnaires assessing potential were completed by 5,487 dermatology outpatients 2,808 skin-healthy controls. Dermatological diagnosis, severity, comorbidity...
Hereditary angioedema (HAE), an inherited deficiency offunctional C1 esterase inhibitor (C1-INH), is characterized byrecurrent episodes of disabling and often painful swelling insubcutaneous and/or submucosal tissues.1HAE attacks aregenerally unpredictable, but triggers for attack can includehaving a dental or medical procedure (eg, surgery), other trauma,or stress. A preemptive management plan patients under-going these types situations may reduce the risk HAE at-tacks. Recommendations...
Background: The coronavirus disease 2019 (COVID-19) pandemic has greatly affected health-care provision across the globe. Management of chronic ailments become challenging because strained resources and social distancing measures that prevent on-site clinical visits treatments. Hereditary angioedema (HAE) is a debilitating, characterized by unpredictable swelling attacks in various parts body. Controlling HAE symptoms often requires long-term prophylactic medication use regular medical care;...
Attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency (C1-INH-HAE) usually begin during childhood or adolescence. However, limited data are available regarding indications and modalities treatment children. This study evaluated recombinant human C1-INH (rhC1-INH) for HAE attacks in children.This open-label, phase 2 included children aged 2-13 years with C1-INH-HAE. Eligible were treated intravenously rhC1-INH 50 IU/kg body weight (maximum, 4200 IU). The primary...
Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disease, characterized by swellings. We aimed characterize on clinical and molecular basis C1-INH-HAE patients in the Republic of Macedonia.All 15 from six unrelated families were diagnosed with type I, mean age symptom onset 11 years an average delay diagnosis seven years. Patients reported 31 attacks/year, median severity score (CSS) 7. identified three known mutations two new (c.813_818delCAACAA c.1488T > G) that...
Hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency (C1-INH-HAE) is characterized by recurrent swelling attacks. A European treatment registry was established review the adverse event profile and efficacy of recombinant human (rhC1-INH) for HAE attacks.Individuals with C1-INH-HAE were enrolled following a decision treat rhC1-INH provision written informed consent. Medical history baseline information collected at screening. Healthcare providers entered data on attacks,...
Time to onset of symptom relief in hereditary angioedema (HAE) is a common primary end point clinical studies but it has never been validated by correlation with the course HAE symptoms. This study was designed as retrospective validation for placebo-controlled phase II/III patients HAE. Ninety-eight abdominal attacks were treated 10 or 20 U/kg highly purified C1 esterase inhibitor (C1-INH) concentrate placebo. The time relief, determined patients. Patients assessed intensity symptoms pain,...
Hereditary angioedema (HAE), an inherited deficiency of functional C1 esterase inhibitor (C1-INH), is characterized by unpredictable recurrent episodes painful and often disabling swelling in subcutaneous and/or submucosal tissues. We report the case a 23-year-old woman with type I HAE who had abdominal, facial, peripheral attacks throughout her first pregnancy. A facial attack occurred at week 38 pregnancy, symptoms improved after self-administration 50 U/kg recombinant human C1-INH (total...
Hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) is a rare genetic disorder caused by pathogenic variants in the SERPING1 gene and characterised swelling highly variable clinical phenotype. We aimed identify novel modifying factors predisposing symptoms. performed whole exome sequencing (WES) comprehensive bioinformatic analysis symptomatic asymptomatic (three duos) family members with HAE-C1-INH. Selected identified using WES (present all absent patients) were determined...
Abstract Background Dysmorphic concern is an overconcern with imagined or slight defect in physical appearance that can be a symptom of body dysmorphic disorder (BDD). Appearance‐related concerns are frequently reported by people dermatological conditions. However, relatively little remains known about the relationship between and other variables within persons different skin Objectives The aim this multicentre, cross‐sectional study was to investigate gender differences regarding prevalence...
Hidradenitis suppurativa (HS) can severely affect the quality of life (QoL) and is linked to psychological distress, including anxiety, depression, reduced self-esteem. Stigmatization due physical appearance may significantly contribute burden impact on QoL for HS patients. This study investigates association between stigmatization, health- disease-related variables among patients in Europe.