A5000546208- Cancer, Lipids, and Metabolism
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Research in Cotton Cultivation
- Long-Term Effects of COVID-19
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Lipoproteins and Cardiovascular Health
- Lymphoma Diagnosis and Treatment
- Air Quality and Health Impacts
- Functional Brain Connectivity Studies
- HIV/AIDS drug development and treatment
- Pancreatitis Pathology and Treatment
- Medical Imaging Techniques and Applications
- Acute Lymphoblastic Leukemia research
- Lung Cancer Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- HIV Research and Treatment
- Tryptophan and brain disorders
- Cerebrovascular and Carotid Artery Diseases
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Disease and Adiposity
- Radiomics and Machine Learning in Medical Imaging
- Fungal and yeast genetics research
- Diet, Metabolism, and Disease
Wuhan University
2019-2025
Guangzhou Center for Disease Control and Prevention
2024-2025
University of Minnesota
2024-2025
Zhongnan Hospital of Wuhan University
2020-2025
Shaanxi University of Science and Technology
2023-2024
Twin Cities Orthopedics
2024
First Affiliated Hospital of Zhengzhou University
2024
Hangzhou Xixi hospital
2024
Tongji Hospital
2024
Renmin Hospital of Wuhan University
2020-2023
Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in patients with hypertension. Objective: To determine the association between in-hospital use ACEI/ARB all-cause mortality hypertension hospitalized due to COVID-19. Methods Results: This retrospective, multi-center study included 1128 adult diagnosed COVID-19, including 188 taking (ACEI/ARB group;...
Background and Aims Coronavirus disease 2019 (COVID‐19) is a new infectious disease. To reveal the hepatic injury related to this its clinical significance, we conducted multicenter retrospective cohort study that included 5,771 adult patients with COVID‐19 pneumonia in Hubei Province. Approach Results We reported distributional temporal patterns of liver indicators these determined their associated factors death risk. Longitudinal function tests were retrospectively analyzed correlated risk...
The prognostic power of circulating cardiac biomarkers, their utility, and pattern release in coronavirus disease 2019 (COVID-19) patients have not been clearly defined. In this multicentered retrospective study, we enrolled 3219 with diagnosed COVID-19 admitted to 9 hospitals from December 31, March 4, 2020, estimate the associations injury markers poor outcomes COVID-19. mixed-effects Cox model, after adjusting for age, sex, comorbidities, adjusted hazard ratio 28-day mortality hs-cTnI...
Quantitative nuclear magnetic resonance (NMR) metabolomics techniques provide detailed measurements of lipoprotein particle concentration. Metabolic dysfunction often represents a cluster conditions, including dyslipidaemia, hypertension, and diabetes, that increase the risk cardiovascular diseases (CVDs). However, causal relationship between lipid profiles blood pressure (BP) remains unclear. We performed Mendelian Randomisation (MR) study to disentangle prioritize potential effects major...
Hereditary angioedema is a life-threatening illness caused by mutations in the gene encoding C1 inhibitor (also called esterase inhibitor) that lead to overactivation of kallikrein-bradykinin cascade. BCX7353 potent oral small-molecule plasma kallikrein with pharmacokinetic and pharmacodynamic profile may help prevent attacks.In this international, three-part, dose-ranging, placebo-controlled trial, we evaluated four doses (62.5 mg, 125 250 350 mg once daily) for prevention attacks over...
Global distributions and trends of the risk-attributable burdens chronic obstructive pulmonary disease (COPD) have rarely been systematically explored. To guide formulation targeted accurate strategies for management COPD, we analyzed COPD attributable to known risk factors.Using detailed data from Burden Disease study 2019, disability-adjusted life years (DALYs), lived with disability (YLDs), lost (YLLs), deaths each factor 1990 2019. Additionally, calculated estimated annual percentage...
Emerging evidence suggests an association between remnant cholesterol (RC) and vascular damage hypertension. However, this has not been explored in a large-scale population China, temporal relationship RC hypertension also needs to be investigated.We conducted retrospective cross-sectional study 2,199,366 individuals longitudinal 24,252 with repeated measurements of lipid profile blood pressure at least 3-year follow-up. The logistic model was used explore the components analysis. Cox...
Rationale Aortic aneurysm (AA) is a serious condition that largely increases the risk of aortic dissection and sudden death. Exploring global burden disease changes in factors for AA essential public health policy development.Objective To project death from its attributable following decade based on epidemiological data over past 30 years.Methods Results We analysed trends four 1990–2019 using updated 2019 Global Burden Disease study database by Joinpoint regression analysis. Furthermore, we...
Background and aims The epidemiological characteristics of MAFLD its relationship with atrial fibrillation (AF) are limited in China. Therefore, we explored the from adults along association 12-ECG diagnosed AF a nationwide population health check-up centers. Methods This observational study used cross-sectional longitudinal studies 2,083,984 subjects 2009 to 2017. Age-, sex-, regional-standardized prevalence was estimated. Latent class analysis (LCA) identify subclusters MAFLD....
Background and aims Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly emerged term that suggested to better reflect the pathogenesis of nonalcoholic (NAFLD); however, association between hyperuricemia MAFLD has not been explored in Chinese population. Meantime, this study also examined temporal relationship two entities longitudinal cohort. Methods We conducted retrospective cross-sectional including 1,587,962 individuals from 19 health check-up centers China 2009-2017...
Background Rheumatic heart disease (RHD) remains the leading cause of preventable death and disability in children young adults, killing an estimated 320,000 individuals worldwide yearly. Materials methods We utilized Bayesian age-period cohort (BAPC) model to project change burden from 2020 2030 using data Global Burden Disease (GBD) Study 2019. Then we described projected epidemiological characteristics RHD by region, sex, age. Results The global age-standardized prevalence rate (ASPR)...
Background and aimsThe distribution of lipoprotein(a) [Lp(a)] has not been well-studied in a large population China. The relationship between Lp(a) carotid atherosclerosis remains undefined. In this study, we aimed to investigate the levels assess their association with arteriopathy China.MethodsIn cross-sectional 411,634 adults measurements from 22 health check-up centers were used Among participants data, ultrasound was performed routinely at seven covering 75,305 subjects. Carotid...