A5103932416- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Geometric Analysis and Curvature Flows
- Geometric and Algebraic Topology
- Nanocomposite Films for Food Packaging
- Nicotinic Acetylcholine Receptors Study
- Geometry and complex manifolds
- Ion channel regulation and function
- Remote Sensing in Agriculture
- Surfactants and Colloidal Systems
- Long-Term Effects of COVID-19
- Metal complexes synthesis and properties
- Phytochemistry and Bioactive Compounds
- Venomous Animal Envenomation and Studies
- Essential Oils and Antimicrobial Activity
- Advanced Drug Delivery Systems
- Nonlinear Partial Differential Equations
- Lipid metabolism and biosynthesis
- Natural product bioactivities and synthesis
- COVID-19 Clinical Research Studies
- Metamaterials and Metasurfaces Applications
- Advanced Operator Algebra Research
- CAR-T cell therapy research
- Antimicrobial agents and applications
- Analytical Chemistry and Chromatography
Wuhan University
2004-2024
Nanchang University
2024
Wuhan Third Hospital
2021
Tongren Hospital
2021
Affiliated Hospital of Southwest Medical University
2021
Western University
2020
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2016
The potassium channel Kv1.3 is an attractive pharmacological target for immunomodulation of T cell-mediated autoimmune diseases. Potent and selective blockers are potential therapeutics treating these Here we describe the design a new peptide inhibitor that potent Kv1.3. Three residues (Gly(11), Ile(28), Asp(33)) scorpion toxin BmKTX were substituted by Arg(11), Thr(28), His(33), resulting in peptide, named ADWX-1. ADWX-1 blocked with picomolar affinity (IC(50), 1.89 pM), showing 100-fold...
Pharmaceutical interactions with human serum albumin (HSA) are of great interest, because HSA is a pharmacokinetic determinant and good model for exploring the protein−ligand interactions. Due to their hydrophobic nature, naturally occurring flavones, which possess various pharmacological activities, bind in plasma. Here, we have identified binding modes two representative flavones—baicalin (BLI) its aglycon, baicalein (BLE)—to using combination experimental computational approaches. The...
Stearyl coenzyme A desaturase (SCD), also known as delta-9 desaturase, catalyzes the rate-limiting step in formation of monounsaturated fatty acids. In mammals, depletion or inhibition SCD activity generally leads to a decrease triglycerides and cholesteryl esters. However, endogenous role <i>scd</i> teleost fish remains unknown. Here, we generated zebrafish mutant (<i>scd</i><sup><i>-/-</i></sup>) elucidate lipid metabolism sexual development. Gas chromatography-mass spectrometry (GC-MS)...
For a long time, the available global products of urban area extent were limited to coarse spatial resolution, e.g., Moderate Resolution Imaging Spectroradiometer (MODIS) land cover (GLC) 500-m data and European Space Agency GlobCover 300-m data. This limitation was broken by GlobeLand30 data, which is world's first 30-m resolution GLC set. However, detection accuracies areas for (i.e., artificial surfaces) are not satisfactory. Therefore, in order refine accuracy on basis we propose novel...
Background: Alantolactone (AL) is a natural compound extracted from the roots of Inula Helenium L, which exerts an anti-tumor effect in variety cancer cell lines; however, its on esophageal cancer, common malignancy with poor prognosis, remains unclear. Therefore, we aim to evaluate AL and explore underlying mechanism. Objective: This study aims determine whether has anti-cancer cells Methods: The proliferation apoptosis was detected by MTT assay, colony formation crystal violet flow...
In this paper, let $ P = \begin{pmatrix}\cos\frac{2\pi}{p} &-\sin\frac{2\pi}{p}\\ \sin\frac{2\pi}{p} &\cos\frac{2\pi}{p} \end{pmatrix}^{\diamond n} be a rotational matrix, and \Sigma \subset\mathbb{R}^{2n} $-symmetric compact convex hypersurface which is (r,R) $-pinched with \frac{R}{r}<\sqrt{\frac{2p+1}{p+1}} $, where the integer p\geq 2 $. Then carries at least two elliptic $-cyclic closed characteristics; moreover, \lceil\frac{(n-1)p}{2(p+1)}\rceil+\lceil \frac{n-1}{2} \rceil...
Rendering an object invisible through a cloaking device is ongoing dream of human beings and material scientists. Recently, intensive theories experiments have predicted demonstrated that such can be realized based on transformation optics metamaterials, in fields electromagnetics, acoustics, or even heat transfer. Metamaterials enable precise control over the propagation waves due to their delicate micro-structures spatially tailorable properties. However, simple natural way achieve without...