A5100416847- Prostate Cancer Treatment and Research
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Fungal Biology and Applications
- Gut microbiota and health
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Reproductive System and Pregnancy
- Toxin Mechanisms and Immunotoxins
- Heat shock proteins research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Flavonoids in Medical Research
First Affiliated Hospital of Xi'an Jiaotong University
2025
Beijing University of Chinese Medicine
2020-2025
Ministry of Agriculture and Rural Affairs
2025
Chinese Academy of Fishery Sciences
2023-2025
University of Macau
2015-2025
Dali University
2025
Shimadzu (China)
2025
Zhengzhou University
2024
Southern Medical University
2007-2024
Henan Provincial People's Hospital
2024
Abstract Engineered skin substitutes derived from human significantly reduce inflammatory reactions mediated by foreign/artificial materials and are consequently easier to use for clinical application. Type I collagen is a main component of the extracellular matrix during wound healing has excellent biocompatibility, platelet‐rich plasma can be used as initiator cascade. Adipose mesenchymal stem cell exosomes crucial tissue repair play key roles in enhancing regeneration, promoting...
Vitamin C (L-ascorbic acid, ascorbate, VC) is a potential chemotherapeutic agent for cancer patients. However, the anti-tumor effects of pharmacologic VC on hepatocellular carcinoma (HCC) and liver stem cells (CSCs) remain to be fully elucidated. Panels human HCC cell lines as well patient-derived xenograft (PDX) models were employed investigate VC. The use risk recurrence examined retrospectively in 613 patients who received curative resection their initial treatment. In vitro vivo...
Abstract Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit clinical application efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA folate (FA-CS-UA-NPs) demonstrated that FA-CS-UA-NPs could effectively diminish off-target effects increase local concentrations UA. Using MCF-7 cells as in vitro model for anti-cancer mechanistic studies, found be easily...
Our previous studies have shown that chlorogenic acid (CGA) could significantly improve acute and chronic liver injury through antioxidant anti-inflammatory activities. However, its effect on non-alcoholic fatty disease (NAFLD) are not entirely clear. This study aims to explore the of CGA NAFLD induced by high-fat diet (HFD) whether it regulates gut microbiota Glucagon-like peptide-1 (GLP-1). mice were established HFD treated with or without CGA. Serum transaminase, fasting blood glucose...
The lack of tumor infiltration by CD8+ T cells is associated with poor patient response to anti-PD-1 therapy. Understanding how regulated key improving treatment efficacy. Here, we report that phosphorylation HRS, a pivotal component the ESCRT complex involved in exosome biogenesis, restricts cytolytic cells. Following ERK-mediated phosphorylation, HRS interacts and mediates selective loading PD-L1 exosomes, which inhibits migration into tumors. In tissue samples from patients melanoma, are...
Abstract The survival of malignant tumors is highly dependent on their intrinsic self-defense pathways such as heat shock protein (HSP) during cancer therapy. However, precisely dismantling self-defenses to amplify antitumor potency remains unexplored. Herein, we demonstrate that nanoparticle-mediated transient receptor potential vanilloid member 1 (TRPV1) channel blockade potentiates thermo-immunotherapy via suppressing factor (HSF1)-mediated dual pathways. TRPV1 inhibits...
Abstract Background The recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains a major clinical problem. Cells that survive the sublethal heat stress is induced by incomplete RFA are main source HCC relapse. Heat has long been reported to increase intracellular reactive oxygen species (ROS) generation. Although ROS can induce apoptosis, pro-survival effect also demonstrated. However, role in cells exposed unclear. Methods HepG2 and HuH7 were used for this...
A highly effective external photocatalyst- and additive-free method for the phosphorylation of 3,4-dihydroquinoxalin-2(1
RNAi approaches have been widely combined with platinum-based anticancer agents to elucidate cellular responses and target gene products that mediate acquired resistance. Recent work has demonstrated platination of siRNA prior transfection may negatively influence efficiency based on the position sequence its guanosine nucleosides. Here, we used detailed spectroscopic characterization demonstrate rapid formation Pt-guanosine adducts within 30 min after coincubation oxaliplatin [OxaPt(II)] or...
Abstract Background There are a lot of unmet needs in patients with triple-negative breast cancer (TNBC). Fenofibrate, peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, has been used for decades to treat hypertriglyceridaemia and mixed dyslipidaemia. Recent studies show that it might have anti-tumor effects, however, the mechanism remains unclear. Here, we assessed ability fenofibrate induce apoptosis TNBC vitro vivo explored involved mechanisms. Methods MTT method was...