A5091835136- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Heat shock proteins research
- interferon and immune responses
- Quantum Dots Synthesis And Properties
- Animal Nutrition and Physiology
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Vector-borne infectious diseases
- Ion Channels and Receptors
- Inhalation and Respiratory Drug Delivery
- Protease and Inhibitor Mechanisms
- Herpesvirus Infections and Treatments
Soochow University
2022-2024
Changshu No.1 People's Hospital
2024
Northeast Agricultural University
2014
Daqing Normal University
2014
Abstract The survival of malignant tumors is highly dependent on their intrinsic self-defense pathways such as heat shock protein (HSP) during cancer therapy. However, precisely dismantling self-defenses to amplify antitumor potency remains unexplored. Herein, we demonstrate that nanoparticle-mediated transient receptor potential vanilloid member 1 (TRPV1) channel blockade potentiates thermo-immunotherapy via suppressing factor (HSF1)-mediated dual pathways. TRPV1 inhibits...
Abstract Background Hematological metastasis has been recognized as a crucial factor contributing to the high rates of and mortality observed in colorectal cancer (CRC). Notably, exosomes derived from cells participate formation CRC pre-metastatic niches; however, mechanisms underlying their effects are largely unknown. While our preliminary research revealed role exosome-derived disintegrin metalloproteinase 17 (ADAM17) early stages metastasis, exosomal ADAM17 hematogenous remains unclear....
Oral squamous cell carcinoma (OSCC) contributes to more than 90% of all oral malignancies, yet the performance traditional treatments is impeded by limited therapeutic effects and substantial side effects. In this work, we report a combinational treatment strategy based on tumor exosome-based nanoparticles co-formulating photosensitizer (Indocyanine green) tyrosine kinase inhibitor (Gefitinib) (IG@EXOs) for boosting antitumor efficiency against OSCC through synergistic phototherapy-molecular...