A5069504454- Nitric Oxide and Endothelin Effects
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Pulmonary Hypertension Research and Treatments
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Protein Degradation and Inhibitors
- Bacteriophages and microbial interactions
- Healthcare Systems and Reforms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Advanced biosensing and bioanalysis techniques
- Renin-Angiotensin System Studies
- Cardiovascular Function and Risk Factors
- Epigenetics and DNA Methylation
- Healthcare Policy and Management
- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
Chengdu Women's and Children's Central Hospital
2025
Chengdu Medical College
2025
Shanghai Jiao Tong University
2019-2024
Shanghai Institute of Hematology
2024
Ruijin Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
National Clinical Research Center for Digestive Diseases
2023
Sichuan University
2023
State Key Laboratory of Oral Diseases
2023
Air Force Medical University
2017-2022
Over the past decade, China has implemented reforms designed to expand access health care in rural areas. Little objective evidence exists, however, on quality of that care. This study reports results from a standardized patient assess delivered by village clinicians China. To measure quality, we recruited individuals local community serve as undercover patients and trained them present consistent symptoms two common illnesses (dysentery angina). Based 82 covert interactions between...
The renin-angiotensin system exerts a tremendous influence over fluid balance and arterial pressure. Angiotensin II (Ang-II), the effector peptide of system, acts in central nervous to regulate neurohumoral outflow thirst. Dysregulation Ang-II signaling is implicated cardiovascular diseases; however, mechanisms remain poorly understood. Recently we established that NADPH oxidase (Nox)–derived superoxide acting forebrain subfornical organ critical physiological responses Ang-II. In addition,...
Abstract The mechanisms associated with the induction of systemic immune responses by nanoparticles are not fully understood, but their elucidation is critical to address safety issues broader medical application nanotechnology. In this study, a key role nanoparticle‐induced exosomes (extracellularly secreted membrane vesicles) as signaling mediators in T helper cell type 1 (Th1) activation demonstrated. vivo exposure magnetic iron oxide (MIONs) results significant exosome generation...
Background/Aims: In a previous study, we showed that κ-opioid receptor stimulation with the selective agonist U50,488H ameliorated hypoxic pulmonary hypertension (HPH). However, roles arterial smooth muscle cell (PASMC) proliferation, apoptosis, and autophagy play in receptor-mediated protection against HPH are still unknown. The goal of present study was to investigate role U50,488H-induced underlying mechanisms. Methods: Rats were exposed 10% oxygen for three weeks induce HPH. After...
Herein, an ultrasensitive photoelectrochemical (PEC) assay was developed for the monitoring of microRNA-141 (miRNA-141) based on poly{4,8-bis[5-(2-ethylhexyl)thiophen-2-yl]benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl-alt-3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophene-4,6-diyl}/CdTe quantum dots ( PTB7-Th/CdTe QDs) sensitized structure as signal tag and benzo-4-chlorohexadienone (4-CD) precipitate efficient quencher. PTB7-Th CdTe QDs were successively modified electrode surface to form...
This study aimed to explore the correlation between deletion of CDKN2A/B gene and prognosis pediatric acute lymphoblastic leukemia (ALL) patients. A total 310 patients who were diagnosed with at our hospital from January 2020 September 2023 included in this study. Among them, 78 final analysis. Additionally, ALL without deletion, during same period, randomly selected for comparison. statistical analysis was conducted compare clinical characteristics group non-deletion The results showed that...
China is reforming its health care system. It aims to strengthen primary through building community facilities and assigning a 'gate-keeper' role providers. However, it remains unknown whether are able fulfil such mission. This study evaluated the service capacity of selected sample competency practitioners employed by those facilities.Three municipalities from east, middle west were purposely selected. A questionnaire was undertaken in 45 randomly three 700 responded survey. The survey...
Objection: Cumulative studies have identified the effectiveness of cardiac shock wave therapy (CSWT) in treating heart failure after acute myocardial infarction (AMI), but little been discussed with regard to beneficial effects CSWT on anti-fibrosis along underlying mechanism. In this study, we investigated whether could reduce post-AMI fibrosis and further explored molecular Methods: Rat (HF) models induced by ligating left anterior descending coronary artery were established validated...
Exosomes are nanosized vesicles originating from endosomal compartments and secreted by most living cells. In the past decade, exosomes have emerged as potent tools for cancer immunotherapy due to their important roles in modulation of immune responses, promising results been achieved exosome-based immunotherapy. The recent rapid progress nanotechnology, especially on tailored design nanocarriers drug delivery based both passive active targeting strategies, sheds light re-engineering native...
Treatment with As-IV significantly decreased mPAP, RVP and RV/(LV + S) attenuated the development of HPH.
Hemodynamic overload causes cardiac hypertrophy leading to heart failure. Wnt signaling pathway was reported activated in Secreted frizzled related protein 1 (Sfrp1) is a suppressor of activation. The aim the present study investigate protective effect Sfrp1 on hemodynamic overload- induced dysfunction.A mice transverse aortic constriction (TAC)- failure model established. A recombinant adeno-associated virus 9 (AAV9) vector used deliver gene into myocardium. Fluorescence and...
Recent studies from our laboratory and others have shown that increases in cytoplasmic superoxide (O(2)(·-)) levels Akt activation play a key role agonist-stimulated NF-κB cardiomyocyte hypertrophy vitro. In this study, we tested the hypothesis adenovirus (Ad)-mediated intramyocardial gene transfer of dismutase (AdCu/ZnSOD) or dominant-negative form (AdDNAkt) mice would attenuate pressure overload-induced redox-sensitive transcription factor cardiac hypertrophy. Adult C57BL/6 were subjected...
Despite numerous studies it remains controversial whether nitric oxide (NO·) synthesized by neuronal NOS (nNOS) plays an excitatory or inhibitory role in transmission of baroreflex signals the nucleus tractus solitarii (NTS). In current we sought to test hypothesis that nNOS is involved excitation pathways NTS while excluding pharmacological interventions assessing influence nNOS. We therefore developed, validated and utilized a short hairpin RNA (shRNA) reduce expression rats whose activity...
Ginseng is a plant of the family Acanthopanaceae. It has been used for thousands years in China. known as king hundred herbs. was recorded first Shennong Baicao Jing. found that ginsenoside Rd neuroprotective agent. This article aims to explore protective roles Alzheimer's disease. Rd, Chinese herb, may be promising treatment drug disease (AD) and also reported related several pathological changes, including deposition Aβ tau hyperphosphorylation AD it decreases APP transgenic mice.In this...
To enhance the cytotoxicities of our obtained CDK4 inhibitors and get CDK4/HDACs with potent enzymatic inhibitory anti-proliferative activities.A series novel were designed synthesized by incorporating HDAC pharmacophores (hydroxylamine or o-diaminoaniline) into basic structure newly 2-anilino-4-triazolpyrimidine based inhibitors. The (HDAC1, CDK2, CDK4, CDK6) activities these compounds evaluated. Moreover, isoforms activity, cell cycle arrest assay, apoptosis analysis, migration, colony...