A5100600667- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Microbial Fuel Cells and Bioremediation
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Stress Responses and Cortisol
- Kruppel-like factors research
- MicroRNA in disease regulation
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Synthesis and Reactions of Organic Compounds
- Hydrology and Watershed Management Studies
- Peptidase Inhibition and Analysis
- Synthesis and Biological Evaluation
- Constructed Wetlands for Wastewater Treatment
- Cryospheric studies and observations
- Liver physiology and pathology
- Water-Energy-Food Nexus Studies
- Gut microbiota and health
- Innovation Diffusion and Forecasting
- Bone Metabolism and Diseases
- IL-33, ST2, and ILC Pathways
- RNA Research and Splicing
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
Beijing City University
2024
Jilin University
2019-2024
Shanghai University of Traditional Chinese Medicine
2023-2024
Gansu Academy of Agricultural Sciences
2024
Anhui University of Finance and Economics
2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2023-2024
Beijing Institute of Education
2023-2024
Anhui University of Traditional Chinese Medicine
2024
Hangzhou City University
2024
Shihezi University
2018-2024
Abstract Controlling the structure and properties of catalysts through atomic arrangement is source producing a new generation advanced catalysts. A highly active stable catalyst in catalytic reactions strongly depends on an ideal metal atoms. We demonstrated that introduction defect‐rich structures, low coordination number (CN), tensile strain three‐dimensional (3D) urchin‐like palladium nanoparticles chlorine bonded with sp‐C graphdiyne (Pd‐UNs/Cl‐GDY) can regulate atoms to form special...
Abstract Anorexia nervosa (AN) results in gut dysbiosis, but whether the dysbiosis contributes to AN-specific pathologies such as poor weight gain and neuropsychiatric abnormalities remains unclear. To address this, germ-free mice were reconstituted with microbiota of four patients restricting-type AN (gAN mice) healthy control individuals (gHC mice). The effects microbes on behavioral characteristics examined. Fecal microbial profiles recipient gnotobiotic clustered those human donors....
The present work investigated the effect of 90 days' traditional fermentation on phytochemicals and inhibition towards α-glucosidase dipeptidyl peptidase-IV (DPP-IV) pickled chili pepper, clarified their possible mechanisms based molecular docking analysis. results show that significantly enhanced for but reduced inhibitory effects DPP-IV (P < 0.05), especially fermented 42 days. In peppers, a total 12 phytochemical compounds were characterized quantified, which kaempferol-3-O-rutinoside,...
Abstract Aberrant sterol lipid metabolism is associated with physiological dysfunctions in the aging brain and aging-dependent disorders such as neurodegenerative diseases. There an unmet demand to comprehensively profile lipids spatially temporally different regions during aging. Here, we develop ion mobility-mass spectrometry based four-dimensional sterolomics technology leveraged by a machine learning-empowered high-coverage library (>2000 lipids) for accurate identification. We apply...
// Cong Guo 1 , Jia Su Zhijun Li 2 Rui Xiao Jianxun Wen Yanyan 3 Meng Zhang Xueting Donna Yu 4 Wendong Huang Wei-Dong Chen 2, Yan-Dong Wang State Key Laboratory of Chemical Resource Engineering, College Life Science and Technology, Beijing University Beijing, P. R. China Molecular Pathology, School basic medical science, Inner Mongolia Medical University, Hohhot, Mongolia, Receptors-Mediated Gene Regulation Drug Discovery, Medicine, Henan Kaifeng, Henan, Department Diabetes Metabolic...
To investigate the role and possible molecular mechanism of Krüppel-like factor 7 (KLF7) in TLR4/NF-κB/IL-6 inflammatory signaling pathway activated by free fatty acids (FFA).The mRNA protein expression levels KLF7 factors signal pathways were detected qRT-PCR Western blotting after cell culture with different concentrations palmitic acid (PA). The or TLR4 adipocytes was upregulated downregulated; that, these key detected. downregulated while PA stimulated adipocytes, then expressions...
In this study, the effects of thermal processing (TP), high pressure (HHP), and preservatives addition, i.e. sodium metabisulfite (SMS), on flavor changes in acidified chili peppers were compared. their during different storage periods (25, 37, 42 °C for 30 days) also investigated. The results indicate that TP clearly changed properties compared to other processing, such as an increase organic acid contents titratable (TA) values but a decrease pH value, free amino (FAA) concentrations, some...
As one of the most common forms cancer that threatens men's health, prostate (PCa) is under a trend increasing morbidity and mortality in countries. More more studies have pointed out obesity closely linked to occurrence development PCa, although there are still many undiscovered molecular mechanisms between two.In present study, we compare serum lipid levels patients with PCa normal individuals. cells (PC3 22RV1) were cultured vitro, TC/TG/HDL/GLU assay kit was used detect glucose...
Abstract Background Obesity-induced abnormal bone marrow microenvironment is one of the important risk element for metastasis in prostate cancer (PCa). The present study aimed to determine whether obesity-induced elevation palmitic acid (PA), which most abundant free fatty acids (FFAs), increased CCL2 via GPRs/KLF7 pathway adipocytes (BMA) facilitate PCa growth and metastasis. Methods We constructed a bone-tumor bearing mouse model with obesity through high-fat diet, observed tumor formation...
To investigate the protective effect of a recombinant adeno-associated virus carrying thymosin β4 (AAV-Tβ4) on murine colitis via intracolonic administration.AAV-Tβ4 was prepared and intracolonically used to mediate secretory expression Tβ4 in mouse colons. Dextran sulfate sodium (DSS) applied induce ulcerative colitis, 2,4,6-trinitrobenzene sulfonic acid (TNBS) establish model resembling Crohn's disease. The disease severity colon injuries were observed graded reveal effects AAV-Tβ4...
Objection: Cumulative studies have identified the effectiveness of cardiac shock wave therapy (CSWT) in treating heart failure after acute myocardial infarction (AMI), but little been discussed with regard to beneficial effects CSWT on anti-fibrosis along underlying mechanism. In this study, we investigated whether could reduce post-AMI fibrosis and further explored molecular Methods: Rat (HF) models induced by ligating left anterior descending coronary artery were established validated...
Acoustic metamaterials, artificial composite structures with exotic material properties used to control elastic waves, have become a new frontier in physics, materials science, engineering and chemistry. In this paper, the research progress development prospect of acoustic metamaterials are reviewed. Related studies on passive active introduced compared. Additionally, we discuss approaches structure design, including topology optimization approaches, as well bio-inspired fractal...
The present study aimed to explore the molecular mechanism underlying regulation of glucose metabolism by miR-548ag. For first time, we found that miR-548ag expression was elevated in abdominal adipose tissue and serum subjects with obesity type 2 diabetes mellitus (T2DM). conditional knockout Dicer notably reduced content mouse tissue, serum, liver tissue. combined use RNAseq, an miRNA target gene prediction software, dual luciferase reporter assay confirmed exerts a targeted regulatory...