A5022624268- Autism Spectrum Disorder Research
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Sleep and Wakefulness Research
- Cancer-related cognitive impairment studies
- Lung Cancer Research Studies
- Pancreatic function and diabetes
- Neural dynamics and brain function
- Renal and related cancers
- Renal cell carcinoma treatment
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Alzheimer's disease research and treatments
- Tuberous Sclerosis Complex Research
- Neuroinflammation and Neurodegeneration Mechanisms
Allen Institute for Brain Science
2019-2024
Johns Hopkins University
2019-2024
Georgetown University
2020-2023
Georgetown University Medical Center
2022
Alterations to the excitation/inhibition (E/I) ratio are postulated underlie behavioral phenotypes in autism spectrum disorder (ASD) patients and mouse models. However, wild type mice E/I is not constant, but instead oscillates across 24-h day. Therefore, we tested whether regulation, rather than overall ratio, disrupted two ASD-related lines: Fmr1 KO BTBR, models of syndromic idiopathic ASD, respectively. The dysregulated both models, different ways: oscillation lost reversed BTBR mice....
APOE is an immunomodulator in the brain and major genetic risk factor for late-onset Alzheimer's disease (AD). Targeted replacement mice (APOE-TR) have been a useful tool to study effects of isoforms on neurochemistry activity prior during AD. We use newly available knock-in (JAX-APOE) compare phenotypes associated with APOE4 across models. Similar APOE4-TR mice, JAX-E4 mouse brains showed 27% lower levels protein compared JAX-E3 (p < 0.001). analyzed several neuroinflammatory molecules that...
Wilms tumor (WT) is one of the most common renal malignancies in children, comprising about 5% all childhood cancers. If diagnosed early, WT responds well to appropriate interventions such as surgical resection, chemotherapy and radiotherapy, with a 5 year survival higher than 85%. In this review, we will describe first-line treatment options for WT, discuss controversies related particular modes therapy, highlight promising advances molecular biology that may serve effective therapeutics...
ABSTRACT Alterations to the balance between excitation and inhibition (E/I ratio) are postulated underlie behavioral phenotypes in autism spectrum disorder (ASD) patients mouse models. However, wild type mice E/I ratio is not constant, but instead oscillates across 24h day. Therefore, we tested whether oscillation, rather than overall ratio, disrupted two ASD-related lines: Fmr1 KO BTBR, models of syndromic idiopathic ASD, respectively. The dysregulated both models, different ways:...
Abstract Background APOE4 has broad effects, one of which is worsened cognitive outcomes in cancer survivors following chemotherapy treatment compared to APOE3 . Method 1‐2 month old female and ‐Targeted Replacement (TR) mice were used for whole cell patch‐clamp experiments the entorhinal cortex. Chemotherapy was introduced via a single injection doxorubicin (10 mg/kg) or saline (control) treated APOE ‐TR euthanized 1 week post‐injection. 0.5% biocytin internal solution visualize morphology...