A5100422559- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Melanoma and MAPK Pathways
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer, Hypoxia, and Metabolism
- Dermatologic Treatments and Research
- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
- Plant Pathogens and Fungal Diseases
- interferon and immune responses
- Hedgehog Signaling Pathway Studies
- RNA Research and Splicing
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Zebrafish Biomedical Research Applications
- Natural product bioactivities and synthesis
- Protein Tyrosine Phosphatases
Shandong Agricultural University
2009-2025
Academy of Military Medical Sciences
2022-2025
China Pharmaceutical University
2014-2025
Marine Biology Institute of Shandong Province
2012-2025
Second Military Medical University
2022-2025
Shanghai Pudong New Area Gongli Hospital
2022-2025
Jiangsu University
2025
Cancer Center of Hawaii
2025
University of Hawaiʻi at Mānoa
2025
University of Hawaii System
2025
Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously in response to environmental stress have long been implicated tissue injury the context of a variety disease states. ROS/RNS can cause cell death by nonphysiological (necrotic) regulated pathways (apoptotic). The mechanisms which regulate apoptosis typically include receptor activation, caspase Bcl-2 family proteins, and mitochondrial dysfunction. Various protein kinase activities, including mitogen-activated kinases,...
Carbon monoxide (CO), a byproduct of heme catabolism by oxygenase (HO), confers potent antiinflammatory effects. Here we demonstrate that CO derived from HO-1 inhibited Toll-like receptor (TLR) 2, 4, 5, and 9 signaling, but not TLR3-dependent in macrophages. Ligand-mediated trafficking to lipid rafts represents an early event signal initiation immune cells. Trafficking TLR4 response LPS was reactive oxygen species (ROS) dependent because it diphenylene iodonium, inhibitor NADPH oxidase,...
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has morbidity and mortality in humans. It is urgent to understand the function of viral genes. However, open reading frame 10 (ORF10), which uniquely expressed SARS-CoV-2, remains unclear. In this study, we showed that overexpression ORF10 markedly suppressed expression type I interferon (IFN-I) genes IFN-stimulated Then, mitochondrial antiviral signaling protein (MAVS) was...
Soil microorganisms play an important role in the ecosystem, and have a certain relationship with continuous cropping obstacles, which are common sweet potato. However, there few reports on effects of potato microbial community structure rhizospheric soil. Here, we investigated fungal soil, order to provide theoretical basis for prevention control obstacles. This study used X18 Y138 varieties as experimental materials. samples were collected during early period planting harvest two...
Abstract The introduction of glucose oxidase, exhibiting characteristics consumption and H 2 O production, represents an emerging antineoplastic therapeutic approach that disrupts nutrient supply promotes efficient generation reactive oxygen species (ROS). However, the instability natural enzymes their low efficacy significantly impede broader application. In this context, 2D Ca Mn 8 16 nanosheets (CMO NSs) designed engineered to serve as a high‐performance nanozyme, enhancing enzyodynamic...
Abstract Fat greenling ( Hexagrammos otakii Jordan & Starks, 1895) is a valuable marine fish species, crucial for aquaculture in Northern China due to its high-quality meat and significant economic value. However, the industry faces challenges such as trait degradation, early sexual maturity, disease susceptibility, necessitating advanced genomic interventions sustainable cultivation. This study presents first chromosomal-level genome assembly of H. , achieved using PacBio long-read...
Cigarette smoke-induced cell death contributes to the pathogenesis of chronic obstructive pulmonary disease, though relative roles apoptosis and autophagy remain unclear. The inducible stress protein heme oxygenase-1 (HO-1) confers cytoprotection against oxidative stress. We examined relationships between these processes in human bronchial epithelial cells (Beas-2b) exposed cigarette smoke extract (CSE). CSE induced morphological biochemical markers Beas-2b autophagosome formation as...
ABSTRACT The heme oxygenase (HO) and nitric oxide synthase (NOS) enzymes generate the gaseous signaling molecules carbon monoxide (CO) oxide, respectively. Constitutive NOSs localize to caveolae, their activities are modulated by caveo‐ lin‐1. Nothing is known of localization inducible oxygenase‐1 (HO‐1) in plasma mem‐ brane caveolae. Thus, we examined distribution subcellular HO‐1, biliverdin reduc‐ tase (BVR), NADPH:cytochrome P450 reductase (NPR) pulmonary artery endothelial cells. Each...
Cancer stem-like cells (CSC) drive cancer progression and recurrence. Self-renewal expansion of CSC is achieved through symmetric cell division, yet how external stimuli affect intracellular regulatory programs division modes stemness remains obscure. Here, we report that the hTERThigh prostate exhibit properties, including a stem cell-associated gene expression signature, long-term tumor-propagating capacity epithelial-to-mesenchymal transition. In promoting self-renewal cells, WNT3a...
The intention to leave a job, known as turnover intention, among primary care doctors has significant impact on health service delivery. We investigated doctors' and analysed associated factors involved in facilities Chongqing, China.A total of 440 were interviewed, they selected using multi-stage stratified random sampling method. survey instrument was self-administered questionnaire which assessed socio-demographic work-related characteristics, job satisfaction intention. data χ2 test,...
Rationale: Cisplatin derivatives are first-line chemotherapeutic agents for epithelial ovarian cancer. However, chemoresistance remains a major hurdle successful therapy and the underlying molecular mechanisms poorly understood at present. Methods: RNA sequencing of organoids (PDO) established from cisplatin-sensitive -resistant cancer tissue samples was performed. Glucose metabolism, cell senescence, chemosensitivity properties were subsequently examined. Immunoprecipitation, mass...
To study the effects of exercise on lysosomal functions.Mouse model was established and wheel running scheduled as 18 rpm (14:00-17:00), 5 d/wk, for 8 weeks. Mice were injected EX527 to inhibit SIRT1 activity. The protein level assayed with Western blot immunofluorescence histochemistry. transmission electron microscopic examination used show structure lysosome mitochondria.Exercise promoted nuclear translocation TFEB in cortex which upregulated transcription genes associated autophagy...
The combination of paclitaxel (PTX) and doxorubicin (DOX) has been widely used in the clinic. However, it remains unsatisfied due to generation severe toxicity. Previously, we have successfully synthesized a prodrug PTX-S-DOX (PSD). displayed comparable vitro cytotoxicity compared with mixture free PTX DOX. Thus, speculated that could be promising improve anti-cancer effect reduce adverse effects by improving pharmacokinetics behavior PSD enhancing tumor accumulation. Due fact copper ions...
Nanochemotherapy combats cisplatin resistance by exploiting increased intracellular hypoxia in cancer cells.
Evidences have suggested that the metabolic function is key regulator to fate of MSCs, but its in senescence MSC and underlying mechanism unclear. Therefore, purpose this study was investigate activity MSCs possible during aging.We used Seahorse XF24 Analyzer understand OCR ECAR BMSCs RT-PCR analyze gene expression mitochondrial biogenesis enzymes glycolysis. We analyzed BMSC by MitoTracker Deep Red JC-1 staining, detected NAD+/NADH ratio ATP levels BMSCs. Microarray proteomic analyses were...
Qing-Xin-Jie-Yu Granule (QXJYG) is an integrated traditional Chinese medicine formula used to treat atherosclerotic (AS) cardiovascular diseases. A randomized controlled trial found that QXJYG reduced events and experiments also verified attenuated AS by remodeling the intestinal flora.To determine whether would attenuate plaque vulnerability regulating ferroptosis in high-fat diet-induced ApoE-/- mice investigate effects of on macrophage RAS-selective lethal 3 (RSL3)-induced J744A.1...
Chemodynamic therapy (CDT) strategies rely on the generation of reactive oxygen species (ROS) to kill tumor cells, with hydroxyl radicals (•OH) serving as key mediators cytotoxicity in this setting. However, efficacy CDT approaches is often hampered by properties microenvironment (TME) and associated limitations Fenton reaction that constrains ROS generation. As such, there a pressing need for design new nanoplatforms capable improving outcomes. In study, an Fc-based metal–organic framework...