A5100324012- Plant-based Medicinal Research
- Pharmacological Effects of Natural Compounds
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- PI3K/AKT/mTOR signaling in cancer
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Animal Nutrition and Physiology
- Colorectal Cancer Treatments and Studies
- Spinal Fractures and Fixation Techniques
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Advancements in Transdermal Drug Delivery
- Hippo pathway signaling and YAP/TAZ
- Heat shock proteins research
- Ginseng Biological Effects and Applications
- Spine and Intervertebral Disc Pathology
- Flavonoids in Medical Research
Qingdao Agricultural University
2021-2025
Qingdao University
2024-2025
Beijing University of Chinese Medicine
2020-2024
Jinhua Central Hospital
2024
Wenzhou Medical University
2024
Zhejiang Chinese Medical University
2013-2024
Chaohu Hospital of Anhui Medical University
2024
Qingdao Women and Children's Hospital
2024
Gannan Medical University
2024
Second Military Medical University
2024
Cancer stem-like cells (CSC) drive cancer progression and recurrence. Self-renewal expansion of CSC is achieved through symmetric cell division, yet how external stimuli affect intracellular regulatory programs division modes stemness remains obscure. Here, we report that the hTERThigh prostate exhibit properties, including a stem cell-associated gene expression signature, long-term tumor-propagating capacity epithelial-to-mesenchymal transition. In promoting self-renewal cells, WNT3a...
The identification of safe and effective drugs that inhibit tumor invasion metastasis is required to improve the clinical outcome patients with colon cancer. present study aimed investigate inhibitory effects possible mechanisms action resveratrol against AKT1‑knockdown SW480 SW620 cancer cells were used detect on cell metastasis, as well changes in expression epithelial‑mesenchymal transition (EMT) markers serine/threonine kinase (AKT)/glycogen synthase (GSK)‑3β/Snail signaling...
This study is aimed to investigate the applicability of poloxamer 407 (P407) and 188 (P188)-based temperature-sensitive in situ hydrogel (TSHG) sustained delivery hydrophilic macromolecules following intramuscular administration. Polyethylene glycols (PEGs) with molecular weight 5-, 20-, 40-kDa were used as model drugs, which can represent common size range macromolecular drugs using TSHG. The correlation between level poloxamers thermogelling transition temperatures (Tsol–gel) was...
Abstract Colorectal cancer (CRC) is the third most common associated with a poor prognosis. Effective targeted therapy alone or in combination for treating advanced CRC remains to be major clinical challenge. Here, we propose therapeutic efficacy and molecular mechanism underlying RC48, FDA-approved anti-HER2 antibody conjugate via cleavable linker microtubule inhibitor monomethyl auristatin E (MMAE), either gemcitabine (GEM) various models of HER2-positive CRC. Our findings demonstrated...
Coccidiosis is one of the major parasitic diseases in commercial broiler industry. Probiotics can protect poultry against Eimeria infection. However, mechanisms are not fully known. Therefore, Lactobacillus plantarum P8 (P8) was used to investigate its anti-coccidial property and mechanism. Five hundred broilers were allocated five treatments: control diet (NC), + infection (IC), containing 1 × 10 7 cfu/g (P8L), 8 (P8H), Diclazuril (DIC). At day 14, all treatments except NC inoculated with...
The aim of the present study was to examine protective effects cinnamaldehyde (CA) on type 1 diabetes mellitus (T1DM) and explore underlying molecular mechanisms by using multiple omics technology.T1DM induced streptozotocin in mice. Immunostaining performed evaluate glycogen synthesis liver morphological changes heart. Gut microbiota analyzed 16S rRNA gene amplification sequencing. serum metabolomics were determined liquid chromatography-mass spectrometry. relevant expression levels...
Ovarian cancer (OC) is a prevalent malignancy in the female reproductive system, and developing effective targeted therapies for this disease remains challenging. The aim of study was to use clinically-relevant OC models evaluate therapeutic effectiveness RC48, an antibody-drug conjugate (ADC) targeting HER2, either alone or combination with VEGFR inhibitor Cediranib Maleate (CM), treatment advanced OC.
Gut microbiota can digest and ferment feed into metabolites to influence the meat quality. Probiotics are used regulate gut microbiota. In this study, a total of 360 broilers were assigned 4 treatments (10 per cage): control (Con), low dose Lactiplantibacillus plantarum HW1 (Lp_L), medium Lp (Lp_M) high (Lp_H) for 42-day experimental period. Results showed that improved growth performance, carcass traits, breast quality, also influenced fatty acids composition, including decrease...
The anticancer effect of baicalein has been known for a number years. However, its anti-metastatic and associated mechanisms in colorectal cancer (CRC) remain unclear. present study investigated the hypothesis that treatment with may inhibit proliferation, motility invasion human CRC cell lines via regulation protein kinase B (AKT) signaling pathway. Baicalein was demonstrated to significantly migration cells (P=0.01). Additionally, after 24 h, expression levels matrix metalloproteinase-2...
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors worldwide and 5-year overall survival rate remains poor. Protein kinase, membrane associated tyrosine/threonine (PKMYT1) overexpressed in several cancers participate tumor progression. However, mechanism PKMYT1 ESCC unclear.The objective our study was to demonstrate expression role ESCC. We detected patients analysed correlation with time disease-free time. Then we lines immortalized human esophageal...
Non-small cell lung cancer (NSCLC) is one of the most common malignancies in world. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been used as a first-line treatment for patients harboring with EGFR mutations advanced NSCLC. Nevertheless, drug resistance after continuous and long-term chemotherapies considerably limits its clinical efficacy. Therefore, it great importance to develop new chemotherapeutic agents strategies conquer resistance. FGFC1 (Fungi...
Mesaconitine (MA), one of the main diterpenoid alkaloids in Aconitum, has a variety pharmacological effects, such as analgesia, anti-inflammation and relaxation rat aorta. However, MA is highly toxic ingredient. At present, studies on its toxicity are mainly focused heart central nervous system, there few reports hepatotoxic mechanism MA. Therefore, we evaluated effects administration liver. SD rats were randomly divided into normal saline (NS) group, low-dose group (0.8 mg/kg/day) high-dose...
Ovarian cancer is the most lethal gynecological tumor, and 5‑year survival rate only ~40%. The poor due to diagnosis at an advanced stage, when tumor has metastasized. A better understanding of molecular pathogenesis growth metastasis needed improve patient prognosis. MicroRNAs (miRs) regulate carcinogenesis development cancers. However, role miR‑508‑3p in ovarian remains largely unknown. Thus, present study aimed investigate possible functions modulation cancer. results demonstrated that...
The purpose of this study was to prepare GeXIVA[1,2] PLGA microspheres by W/O/W re-emulsification-solvent evaporation technology and develop sustained-release formulations meet the clinical treatment needs chronic neuropathic pain. Through prescription optimization, uniformity particle size encapsulation efficiency is improved, so as achieve quality standard microspheres. mechanism trehalose improving stability studied verified molecular simulation. results showed that when adding W1, using...
The purpose of the study was to investigate effects Lactobacillus plantarum HW1 on growth performance, intestinal immune response, barrier function, and cecal microflora broilers with necrotic enteritis. In total, 180 one-day-old male Cobb 500 were randomly allocated into three groups comprising a non-infected control (NC) group, basal diet + enteritis challenge (NE) 4 × 106 CFU/g (HW1) group. Broilers in NE orally given sporulated coccidian oocysts at day 14 Clostridium perfringens from...