A5054605515- Metabolomics and Mass Spectrometry Studies
- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
- Influenza Virus Research Studies
- Pharmacological Effects of Natural Compounds
- Inflammation biomarkers and pathways
- Ferroptosis and cancer prognosis
- Alcohol Consumption and Health Effects
- Respiratory Support and Mechanisms
- Plant-based Medicinal Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Beijing University of Chinese Medicine
2022-2025
Background: Acute lung injury (ALI) is a major cause of death in patients with various viral pneumonias. Our team previously identified four volatile compounds from aromatic Chinese medicines. Based on molecular compatibility theory, we defined their combination as (AC), though its therapeutic effects and underlying mechanisms remain unclear. Methods: This study used influenza A virus (IAV) A/PR/8/34 to construct cell mouse models ALI explore AC’s protective against infection. The effect AC...
Mesaconitine (MA), one of the main diterpenoid alkaloids in Aconitum, has a variety pharmacological effects, such as analgesia, anti-inflammation and relaxation rat aorta. However, MA is highly toxic ingredient. At present, studies on its toxicity are mainly focused heart central nervous system, there few reports hepatotoxic mechanism MA. Therefore, we evaluated effects administration liver. SD rats were randomly divided into normal saline (NS) group, low-dose group (0.8 mg/kg/day) high-dose...
The purpose of this study is to investigate whether chrysin reduces cerebral ischemia-reperfusion injury(CIRI) by inhi-biting ferroptosis in rats. Male SD rats were randomly divided into a sham group, model high-, medium-, and low-dose groups(200, 100, 50 mg·kg~(-1)), positive drug group(Ginaton, 21.6 mg·kg~(-1)). CIRI was induced transient middle artery occlusion(tMCAO). indexes evaluated the samples taken 24 h after operation. neurological deficit score used detect function....
To explore the effect of Ganshuang granule on anti-alcoholic and anti-hangover its potential mechanism.
Ischemic stroke is often associated with a large disease burden. The existence of ischemia-reperfusion injury brings great challenges to the treatment ischemic stroke. purpose this study was explore differences metabolites in different parts brain induced by Shuxuetong injection against cerebral and extend corresponding mechanism. rats were modeled transient middle artery occlusion (t-MCAO) operation, success modeling determined neurological function score TTC staining. UPLC-Q/TOF-MS...
This study aims to explore the mechanism of "simultaneous treatment brain and heart" Naoxintong Capsules(NXT) under cerebral ischemia based on Toll-like receptor(TLR) signaling pathway.Male SD rats were randomized into sham operation group, model NXT positive drug group.Middle artery occlusion(MCAO) used in respectively.Neurological function was scored with Bederson scale, infarct rate measured by 2,3,5-triphenyltetrazolium chloride(TTC) staining.Brain edema detected wet-dry weight...