Herein, two new classes of macrocyclic compounds, terphen[n]arenes (TPns) (n=3-6) and quaterphen[n]arenes (QPns) (n=3-6), were designed synthesized by a one-step condensation reaction in relatively high yields. They comprise 2,2''-dimethoxy terphenyl 2,2'''-dimethoxy quaterphenyl monomers, respectively, linked methylene bridges. Given their long rigid TPns QPns have much larger cavities better self-assembly properties than classic macrocycles. More interestingly, the cyclic pentamers...

Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for detection microenvironment was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) results in an evident blue to green emission wavelength change both solution phases cell lines, which might first probe solid tumors.

A new probe based on the Gabriel mechanism was designed and first used for hydrazine detection with high selectivity against other amines in aqueous solution. Importantly, could be gas-state discrimination of different concentrations. Additionally, also applied imaging living cells.

An optical probe based on colorimetric and ratiometric as well chemiluminometric signal outputs is developed for the specific detection of hydrazine. On basis a Gabriel-type reaction, hydrazinolysis simple CF (4-phtalamide-N-(4'-methylcoumarin) naphthalimide) produces both fluorescence 7-amino-4-methylcoumarin with max emission wavelength changed from 480 to 420 nm (along color change yellow transparent) luminol chemiluminescence activated by H2O2 at 450 nm. The experimental limit hydrazine...

A novel long-wavelength fluorescence probe NBP has been developed for the detection of nitroreductase (NTR) and hypoxia. could be activated by NTR at 0.1 μM to release fluorophore NBF significant changes in emission 658 nm were observed. This feature makes it advantageous imaging hypoxic cells with minimal endogenous interference.

Reported here is the highly efficient separation of industrially important cis- and trans-1,2-dichloroethene (cis-DCE trans-DCE) isomers by activated crystalline 2,2',4,4'-tetramethoxyl biphen[3]arene (MeBP3) materials, MeBP3α. MeBP3 can be synthesized in excellent yield (99 %), a cyclic pentamer also obtained when using 1,2-dichloroethane as solvent. The structure CH3 CN@MeBP3 crystal displays triangle-shape topology, forming 1D channels through window-to-window packing. Desolvated MeBP3α,...

A novel dual-emission fluorescence probe has been developed for specific and sensitive detection of hypochlorite (ClO−). Upon addition ClO−, significant changes in emission intensity at two discrete wavelengths were observed. Meanwhile OONO− led to only a single-channel enhancement. This feature makes it clear advantage distinguishing RNS from other ROS.

Abstract Polyamines are essential for the growth of eukaryotic cells and can be dysregulated in tumors. Here we describe a strategy to deplete polyamines through host–guest encapsulation using peptide-pillar[5]arene conjugate (P1P5A, P1 = RGDSK(N 3 )EEEE) as supramolecular trap. The RGD peptide sequence allows molecule bind integrin α v β -overexpressing tumor cells. negative charged glutamic acid residues enhance inclusion affinities between pillar[5]arene cationic via electrostatic...

Abstract Reported here is a molecule‐Lego synthetic strategy for macrocycles with functional skeletons, involving one‐pot and high‐yielding condensation between bis(2,4‐dimethoxyphenyl)arene monomers paraformaldehyde. By changing the blocks, variously units (naphthalene, pyrene, anthraquinone, porphyrin, etc.) can be conveniently introduced into backbone of macrocycles. Interestingly, macrocyclization tuned by geometrical configuration monomeric blocks. Linear (180°) monomer yield cyclic...

Abstract Organic co‐crystal engineering is a promising method to make multifunctional materials. Here, the marriage of macrocyclic chemistry and provides smart strategy build vapochromic The macrocycle co‐crystals (MCCs) were constructed from π‐electron rich pillar[5]arene (P5) an electron‐deficient pyromellitic diimide derivative (PDI) on 10 g scale. MCCs P5‐PDI are in red owing formation charge‐transfer (CT) complex. After solvent removal, white crystalline solid with new structure (P5‐PDI...

We presented an effective and universal strategy for the improvement of luminophore's solid-state emission, i.e., macrocyclization-induced emission enhancement (MIEE), by linking luminophores through C(sp3) bridges to give a macrocycle. Benzothiadiazole-based macrocycle (BT-LC) has been synthesized one-step condensation monomer 4,7-bis(2,4-dimethoxyphenyl)-2,1,3-benzothiadiazole (BT-M) with paraformaldehyde, catalyzed Lewis acid. In comparison monomer, BT-LC produces much more intense...

Recent progress in quantum dot (QD) based chemo- and biosensors for various applications is summarized.

A new fluorescent probe based on AIE and ESIPT was developed. With the aid of different reactivity, a kinetically resolved method successfully applied to distinguish biothiols both in solution cells.

The design of blue fluorescent materials combining both deep-blue emission (CIEy<0.06) and high-efficiency climbing over the typically limited exciton production efficiency 25% is a challenge for organic light-emitting diodes (OLEDs). In this work, we have synthesized two luminogens, trans-9,10-bis(2-butoxyphenyl)anthracene (BBPA) trans-9,10-bis (2,4-dimethoxyphenyl)anthracene with high photoluminescence quantum yields (PLQYs) 89.5% 87.0%, respectively. Intriguingly, proposed strategy to...

Efficient complexation of sanguinarine by carboxylatopillar[6]arene. The p<italic>K</italic>_ashift, increased solubility, and enhanced antibacterial activity are described.

We developed a near-infrared fluorescence probe for the highly selective and sensitive detection of NAT2 activity. An arylamine was designed as substrate part NATs, well PET quencher cyanine dye. CYP1 with 4-position displayed efficient quenching, exhibited high selectivity sensitivity to no response NAT1. For practical application, we demonstrated could exhibit excellent performance endogenous imaging in living mice. further verified distribution various tissues by detecting corresponding...

A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. The probe, TPQ, displays high selectivity and anti-interference ability, successfully applied to endogenous hNQO1 imaging the identification of different cancer cells.

Abstract Herein, two new classes of macrocyclic compounds, terphen[ n ]arenes (TP s) ( =3–6) and quaterphen[ (QP =3–6), were designed synthesized by a one‐step condensation reaction in relatively high yields. They comprise 2,2′′‐dimethoxy terphenyl 2,2′′′‐dimethoxy quaterphenyl monomers, respectively, linked methylene bridges. Given their long rigid TP s QP have much larger cavities better self‐assembly properties than classic macrocycles. More interestingly, the cyclic pentamers hexamers...

Abstract: A novel structural solid dispersion (SD) taking the form of core–shell microparticles for poorly water-soluble drugs is reported first time. Using polyvinylpyrrolidone (PVP) as a hydrophilic polymer matrix, SDs were fabricated using coaxial electrospraying (characterized by an epoxy-coated concentric spray head), although core fluids unprocessable one-fluid electrospraying. Through manipulating flow rates drug-loaded solutions, two types with tunable drug contents prepared. They...

Abstract Reported here is the highly efficient separation of industrially important cis ‐ and trans ‐1,2‐dichloroethene ( ‐DCE ‐DCE) isomers by activated crystalline 2,2′,4,4′‐tetramethoxyl biphen[3]arene (MeBP3) materials, MeBP3α. MeBP3 can be synthesized in excellent yield (99 %), a cyclic pentamer also obtained when using 1,2‐dichloroethane as solvent. The structure CH 3 CN@MeBP3 crystal displays triangle‐shape topology, forming 1D channels through window‐to‐window packing. Desolvated...

Abstract Catenated cages represent chemistry’s challenging synthetic targets because a three-dimensional assembly is necessary for their formation. Herein, cyclic bis[2]catenane constructed through the coordination-driven self-assembly of interlocked bis-metallacage, by 90° Pt(II) heteroligation endo-functionalized double-bridged tweezer bearing pyridyl moieties and tetra-carboxylated linker. NMR spectrometry, X-ray crystallography mass spectrometry confirm formation with “∞”-shaped topology...

A cascade reaction involving 2‐isocyanophenyl propargylic ester and 4‐hydroxy‐2H‐chromen‐2‐one has been documented. This leads to the formation of a highly strained cyclopropen‐imine species, thereby offering an efficient route synthesize quinoline‐fused polycyclic skeletons.