A5034226178- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Myasthenia Gravis and Thymoma
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Pituitary Gland Disorders and Treatments
- Transplantation: Methods and Outcomes
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Pleural and Pulmonary Diseases
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Sarcoidosis and Beryllium Toxicity Research
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Soft tissue tumor case studies
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Metastasis and carcinoma case studies
- Ear and Head Tumors
Mayo Clinic in Arizona
2016-2025
Mayo Clinic
2016-2025
WinnMed
2016-2025
Mayo Clinic in Florida
2004-2023
National Hospital Organization
2022
Jiangsu Cancer Hospital
2022
Nanjing Medical University
2022
Nanjing General Hospital of Nanjing Military Command
2022
University of Minnesota Rochester
2016-2021
Vall d'Hebron Hospital Universitari
2020
<h3>Importance</h3> Four assays registered with the US Food and Drug Administration (FDA) detect programmed cell death ligand 1 (PD-L1) to enrich for patient response anti–programmed anti–PD-L1 therapies. The tests use 4 separate PD-L1 antibodies on 2 staining platforms have their own scoring systems, which raises questions about similarity potential interchangeability of tests. <h3>Objective</h3> To compare performance platforms, including FDA-cleared assays, test investigational only,...
Pharmacologic stimulation of a G protein–coupled receptor preferentially expressed on fibroblasts reverses experimental lung and liver fibrosis.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its resultant clinical presentation, disease 2019 (COVID-19), is an emergent cause of mortality worldwide. Cardiac complications secondary to this infection are common; however, the underlying mechanisms such remain unclear. A detailed cardiac evaluation a series individuals with COVID-19 undergoing postmortem provided, 4 aims: (1) describe pathological spectrum myocardium; (2) compare alternate viral illness; (3) investigate...
Interleukin (IL)-17 is a T helper 17 cytokine implicated in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). Although IL-17A has well-established role murine pulmonary fibrosis models, its tissue remodeling and occurring idiopathic (IPF) RA-associated interstitial lung disease (RA-ILD) not very well defined. To address this question, we utilized complimentary studies to determine responsiveness human normal pathogenic fibroblasts used biopsies acquired from...
Context.— Mesothelioma is an uncommon tumor that can be difficult to diagnose. Objective.— To provide updated, practical guidelines for the pathologic diagnosis of mesothelioma. Data Sources.— Pathologists involved in International Interest Group and others with expertise mesothelioma contributed this update. Reference material includes peer-reviewed publications textbooks. Conclusions.— There was consensus opinion regarding (1) histomorphologic mesothelial tumors, including distinction...
Abstract Androgen has been implicated as a negative regulator of host immune function and factor contributing to the gender dimorphism autoimmunity. Conversely, androgen deprivation suggested potentiate male immunity. Studies have shown that removal in postpubertal mice produces an increase size cellularity primary peripheral lymphoid organs, enhances variety responses. Yet, few details are known about effect on T cell-mediated In this study, we demonstrate two pronounced independent...
Pulmonary Langerhans cell histiocytosis (PLCH) has been postulated to be a smoking-related non-neoplastic condition, distinct from extrapulmonary LCH, which is generally regarded as clonal, neoplastic process. Recent genomic studies demonstrated BRAF V600E mutation in 38% 57% of LCH cases by polymerase chain reaction. We evaluated the expression immunohistochemistry (IHC) PLCH and cases. compared with status. Our study included 25 (age 42.0±11.4, 10 men) 54 27.6±21.8, 37 Seven (28%) were...
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution and lung repair during severe respiratory viral infections. were to modulate lipid metabolism mitochondrial health in a type-specific manner enhanced alveolar macrophage-mediated tissue regeneration after infection. also prevented inflammasome activation IL-1β release, limiting accumulation...