A5048638469- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Transplantation: Methods and Outcomes
- Lung Cancer Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Occupational and environmental lung diseases
- Tracheal and airway disorders
- Radiopharmaceutical Chemistry and Applications
- Polyomavirus and related diseases
- Sarcoidosis and Beryllium Toxicity Research
- Salivary Gland Tumors Diagnosis and Treatment
- Brain Metastases and Treatment
- Ear and Head Tumors
- Cardiac tumors and thrombi
- Organ Transplantation Techniques and Outcomes
- Histiocytic Disorders and Treatments
- Pleural and Pulmonary Diseases
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
Mayo Clinic in Florida
2016-2025
WinnMed
2016-2025
Jacksonville College
2012-2024
Guardant (United States)
2022
Houston Methodist
2017
Methodist Hospital
2017
Cork University Hospital
2017
Johns Hopkins University
2017
Mayo Clinic
2003-2015
Sylvester Comprehensive Cancer Center
2009
Context.— Mesothelioma is an uncommon tumor that can be difficult to diagnose. Objective.— To provide updated, practical guidelines for the pathologic diagnosis of mesothelioma. Data Sources.— Pathologists involved in International Interest Group and others with expertise mesothelioma contributed this update. Reference material includes peer-reviewed publications textbooks. Conclusions.— There was consensus opinion regarding (1) histomorphologic mesothelial tumors, including distinction...
Abstract Protein kinase C (PKC) isozymes have long been implicated in carcinogenesis. However, little is known about the functional significance of these enzymes human cancer. We recently showed that atypical PKC (aPKC) isozyme PKCι overexpressed non–small cell lung cancer (NSCLC) cells and plays a critical role transformed growth adenocarcinoma A549 line vitro tumorigenicity vivo. Here we provide compelling evidence an oncogene NSCLC based on following criteria: (a) aPKCι vast majority...
The clinicopathologic spectrum of infections due to nontuberculous mycobacteria (NTM) includes cavitary disease, opportunistic infection, and nodular disease associated with bronchiectasis. We report a less well-described manifestation NTM infection: 10 immunocompetent patients without preexisting bronchiectasis had radiographic evidence diffuse infiltrative lung disease. most common symptoms were dyspnea, cough, hypoxia, fever. All used hot tub. Histologic examination revealed exuberant...
Background The development of pulmonary hypertension and its associated increased vascular reactivity is a common accompaniment congenital heart disease with blood flow. Although the morphology changes well described, mechanisms remodeling remain incompletely understood. Methods Results To elucidate these mechanisms, we established an accurate reliable experimental model An aortopulmonary shunt was created 8.0-mm expanded polytetrafluoroethylene graft in 11 late-gestation fetal lambs. At 1...
We determined the temporal and spatial distribution of surfactant protein B (pro-SP-B) C (pro-SP-C) mRNAs proteins by immunohistochemistry in situ hybridization fetal, neonatal, adult human lung. Pro-SP-B SP-B mRNA were detected bronchi bronchioles 15 weeks' gestation. After 25 weeks, pro-SP-B, active peptide, co-localized bronchiolo-alveolar portal cells Type II epithelial cells. In lung, pro-SP-B primarily non-ciliated bronchiolar alveolus. Pro-SP-C SP-C lining terminal airways from...
We used immunolocalization and in situ hybridization to determine the distribution of SP-A mRNA lungs human fetuses normal newborn infants. Early second fetal trimester a few immunostained cells were observed tracheal epithelium, often mucosal folds near origin submucosal gland ducts. Non-mucous for as they became differentiated. Expression was similar that trimester. Immunostained also appeared about same time gestation isolated bronchial epithelium glands. seen bronchiolar pre-Type II...
Abstract Protein kinase Cι (PKCι) is an oncogene required for maintenance of the transformed phenotype non–small cell lung cancer cells. However, role PKCι in tumor development has not been investigated. To address this question, we established a mouse model which oncogenic KrasG12D activated by Cre-mediated recombination with or without simultaneous genetic loss gene, Prkci. Genetic Prkci dramatically inhibits Kras-initiated hyperplasia and subsequent formation vivo. This effect correlates...
Studies of lungs in patients with COVID-19 have focused on early findings.To systematically study histopathologic and imaging features presence SARS-CoV-2 RNA lung tissue from later stages COVID-19.Autopsies, explants, surgical biopsies, transbronchial cryobiopsies, needle biopsies whose onset symptoms/confirmed diagnosis was more than 28 days before the procedure were studied. Available images reviewed. Reverse transcription droplet digital polymerase chain reaction for performed tissue.Of...
Amyloid-like pulmonary nodules have been described in patients with systemic light-chain deposition disease, but their significance other clinical contexts is unknown. We examined biopsy specimens of amyloid-like from 3 women without disease. Patient 1 (aged 62 years) had multiple and underwent 2 separate lung biopsies, the first showing composed κ deposits accompanied by low-grade lymphoplasmacytic lymphoma limited to second, obtained after chemotherapy 9 months later, only residual...
beta-cell type-specific expression of the upstream glucokinase promoter was studied by transfection fusion genes and analysis DNA-protein interactions. A construct containing 1,000 bp 5'-flanking DNA efficiently expressed in HIT M2.2.2 cells, a beta-cell-derived line that makes both insulin glucokinase, but not NIH 3T3 heterologous cell line. In series 5' deletion mutations between bases -1000 -100 (relative to base previously designated +1), efficient cells maintained until -280 bp, after...
Lung squamous cell carcinoma (LSCC) is a prevalent form of lung cancer exhibiting distinctive histological and genetic characteristics. Chromosome 3q26 copy number gain (CNG) hallmark LSCC present in >90% tumors. We report that CNGs occur early tumorigenesis, persist during tumor progression, drive coordinate overexpression PRKCI, SOX2, ECT2. Overexpression ECT2 the context Trp53 loss sufficient to transform mouse basal stem cells into tumors with genomic features LSCC. Functionally, PRKCI...