A5062069675- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Soft tissue tumor case studies
- Occupational exposure and asthma
- Vascular Tumors and Angiosarcomas
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cardiac tumors and thrombi
- Eosinophilic Disorders and Syndromes
- IgG4-Related and Inflammatory Diseases
- Lung Cancer Research Studies
- Tumors and Oncological Cases
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- AI in cancer detection
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Polyomavirus and related diseases
Cardiff University
2014-2025
University Hospital of Wales
2012-2024
University of Wales
1992-2020
Cardiff and Vale University Health Board
2002-2020
University of Chicago Medical Center
2017
Mayo Clinic in Arizona
2017
University Hospital Llandough
2004-2013
Houston Methodist
2013
Methodist Hospital
2013
University of Pittsburgh Medical Center
2013
Context.—. Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose.Objective.—. To provide updated, practical guidelines for the pathologic diagnosis of MM.Data Sources.—. Pathologists involved in International Mesothelioma Interest Group and others with interest expertise field contributed this update. Reference material included up-to-date, peer-reviewed publications textbooks.Conclusions.—. There was discussion consensus opinion regarding (1) distinguishing...
Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose.To provide updated practical guidelines for the pathologic diagnosis of MM.Pathologists involved in International Mesothelioma Interest Group and others with interest field contributed this update. Reference material includes peer-reviewed publications textbooks.There was consensus opinion regarding (1) distinction benign from malignant mesothelial proliferations (both epithelioid spindle cell lesions), (2)...
Context.— Mesothelioma is an uncommon tumor that can be difficult to diagnose. Objective.— To provide updated, practical guidelines for the pathologic diagnosis of mesothelioma. Data Sources.— Pathologists involved in International Interest Group and others with expertise mesothelioma contributed this update. Reference material includes peer-reviewed publications textbooks. Conclusions.— There was consensus opinion regarding (1) histomorphologic mesothelial tumors, including distinction...
Aims: To evaluate the expression of intermediate filament desmin in reactive mesothelium and malignant mesothelioma to compare its utility with five other previously reported immunomarkers claimed be use distinguishing from neoplastic mesothelium. Methods results: Sixty cases pleural 40 mesothelial hyperplasia formed study group. Cases were immunohistochemically stained desmin, epithelial membrane antigen (EMA), p53, Bcl‐2, P‐glycoprotein platelet‐derived growth factor receptor (PDGF‐R)...
Asbestosis is defined as diffuse pulmonary fibrosis caused by the inhalation of excessive amounts asbestos fibers. Pathologically, both a particular pattern and evidence excess in lungs must be present. Clinically, disease usually progresses slowly, with typical latent period more than 20 years from first exposure to onset symptoms.IDIOPATHIC PULMONARY FIBROSIS: The asbestosis interstitial has basal subpleural distribution, similar that seen idiopathic fibrosis, which principal differential...
The diagnosis of interstitial lung diseases (ILDs) often relies on the integration various clinical, radiological, and histopathological data. Achieving high diagnostic accuracy in ILDs, particularly for distinguishing usual pneumonia (UIP), is challenging requires a multidisciplinary approach. Therefore, this study aimed to develop multimodal artificial intelligence (AI) algorithm that combines computed tomography (CT) images improve consistency UIP diagnosis. A dataset CT pathological from...
We undertook a retrospective pathological study of 118 skin resection specimens from 101 patients with hidradenitis suppurativa. Follicular occlusion was identified in all the specimens, regardless disease duration (1 month to 18 years), but not noted axillary and inguinal controls. therefore regard follicular as an early important feature pathogenesis disease. The presence apoeccrine glands provided vivo model directly observe effects on follicle inflammation apocrine gland destruction. In...
To evaluate the role of mesothelial markers (calretinin, thrombomodulin, cytokeratin 5/6, and CD44H) carcinoma (polyclonal monoclonal carcinoembryonic antigen, Leu-M1, CA-125 Ber-EP4) in distinguishing diffuse peritoneal malignant mesothelioma from primary serous papillary adenocarcinoma ovary peritoneum.Paraffin-embedded formalin-fixed blocks 32 mesotheliomas epithelial subtype (all females), 20 ovarian carcinomas three were studied. Calretinin Ber-EP4 appeared to be best positive marker,...
Well-differentiated papillary mesothelioma (WDPM) of the pleura represents a distinct mesothelial tumor presenting with unilateral pleural effusion and superficial spreading stout formations myxoid cores, lined by bland, flattened, or epithelioid cells, without limited invasion submesothelial layer. The majority cases have been reported in peritoneum women reproductive age no history asbestos exposure also tunica vaginalis men. We report 24 WDPM compared their histologic, epidemiologic,...
The 2015 WHO classification of tumors categorized malignant mesothelioma into epithelioid, biphasic (BMM), and sarcomatoid (SMM) for prognostic relevance treatment decisions. survival BMM is suspected to correlate with the amount component. criteria a component interobserver variability between pathologists identifying this are not well described. In ambiguous cases, "transitional" (TMM) subtype has been proposed but was accepted as specific in classification. aims study were evaluate...
To undertake a comparative evaluation of three antimesothelial markers (thrombomodulin, cytokeratin 5/6 and calretinin) with broad spectrum (AE1/AE3) in differentiating between sarcomatoid mesothelioma spindle cell neoplasms.Thirty-one malignant mesotheliomas were studied. Calretinin expression was focally identified 12 (39%) tumours thrombomodulin immunoreactivity seen nine (29%) cases. In comparison there strong diffuse cytoplasmic reactivity the 24 31 (77%) tumours. Thirty mixed cells...
To undertake a clinicopathological study of diffuse serosal neoplasms epithelial histogenesis which clinically and pathologically mimic malignant pleural mesothelioma.Over 10-year (1990-2000) period 53 carcinomas mimicking mesothelioma ('pseudomesotheliomatous' carcinoma) were identified. The group comprised 50 men three females, age range 33-77 (median 68) years. In 46 (87%) cases there was history smoking in 40 (76%) asbestos exposure. Histologically the 'pseudomesotheliomatous' could be...
The clinicopathological features and immunohistochemical findings in 14 primary sarcomas of the lung collected over a 30-year-period are presented. This represents one sarcoma per 550 bronchogenic carcinomas undergoing resection this centre. study group comprised six leiomyosarcomas, five malignant peripheral nerve sheath tumours, two haemangiopericytomas epithelioid haemangioendothelioma. majority cases occurred men (nine males: females), with mean age at presentation 54 years for 47 women....