A5039241530- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Cytokine Signaling Pathways and Interactions
- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Chronic Myeloid Leukemia Treatments
- Esophageal and GI Pathology
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Bowel Disease
- Chronic Lymphocytic Leukemia Research
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Parasitic infections in humans and animals
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Immunodeficiency and Autoimmune Disorders
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Congenital Anomalies and Fetal Surgery
Sapporo Kosei General Hospital
2016-2025
Sendai Kousei Hospital
2012-2023
Hokkaido University
2021
Hokkaido University Hospital
2021
National Hospital Organization Hokkaido Medical Center
2021
Keiyukai Sapporo Hospital
2021
Rush University Medical Center
2017
Columbia College - Missouri
2017
Liquid-based cytology (LBC) for cervical cancer screening is now more common than the conventional smears, which when digitised from glass slides into whole-slide images (WSIs), opens up possibility of artificial intelligence (AI)-based automated image analysis. Since processes by cytoscreeners and cytopathologists using microscopes limited in terms human resources, it important to develop new computational techniques that can automatically rapidly diagnose a large amount specimens without...
The diagnosis of interstitial lung diseases (ILDs) often relies on the integration various clinical, radiological, and histopathological data. Achieving high diagnostic accuracy in ILDs, particularly for distinguishing usual pneumonia (UIP), is challenging requires a multidisciplinary approach. Therefore, this study aimed to develop multimodal artificial intelligence (AI) algorithm that combines computed tomography (CT) images improve consistency UIP diagnosis. A dataset CT pathological from...
In inflammatory bowel disease (IBD), gut inflammation is associated with the activation of nuclear factor kappa B (NF-κB), a key pro-inflammatory transcription factor.To investigate therapeutic potential novel, specific NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), we examined its effect on IBD using murine experimental colitis models.The in vitro DHMEQ was evaluated by cytokine production and p65 immunostaining HT-29 RAW264.7 cells. The vivo studied induced dextran sulphate...
Signet ring cell carcinoma (SRCC) of the stomach is a rare type cancer with slowly rising incidence. It tends to be more difficult detect by pathologists, mainly due its cellular morphology and diffuse invasion manner, it has poor prognosis when detected at an advanced stage. Computational pathology tools that can assist pathologists in detecting SRCC would massive benefit. In this paper, we trained deep learning models using transfer learning, fully-supervised weakly-supervised predict...
Background and Aim Western studies have suggested two distinct etiologies of esophagogastric junction ( EGJ ) cancer: Helicobacter pylori ‐associated atrophic gastritis non‐atrophic gastric mucosa resembling esophageal adenocarcinoma. The present study investigated whether endoscopic mucosal atrophy can distinguish between these types Methods Data were collected from patients with Siewert type II , T1 adenocarcinoma who underwent or surgical resection at eight Japanese institutions in...
Confocal laser endomicroscopy (CLE) has been established for in vivo diagnosis of various gastrointestinal diseases. However, validated criteria confocal duodenal tumors do not exist. Therefore, the aim present pilot study was to develop a novel classification optical using CLE.Consecutive patients with tumorous lesions were included. First, an initial system developed which then validated. Histopathology used as reference standard.A simple epithelial CLE developed. Sensitivity, specificity,...
Abstract Background and Aim With the increasing prevalence of persons without Helicobacter pylori (HP) infection, cases HP‐negative gastric cancer are increasing. Although rare, differentiated adenocarcinoma antrum have been reported in patients. We collected with such lesions investigated their endoscopic histological features. Methods Of 1965 consecutive patients early who underwent resection between January 2009 December 2017, we extracted 9 located (HPN‐DAA). The clinical data, findings,...
Rationale: Gastric adenocarcinoma of fundic gland mucosa type (GA-FGM) is a rare tumor composed atypical cells with differentiation toward the as well foveolar epithelium. Including our case, only 9 cases GA-FGMs were reported from 2010 to 2016. Concerns patient: An 87-year-old man was referred institution for endoscopic resection gastric lesion. The classified 0-I + IIa according Paris classification. Magnifying endoscopy narrow band imaging (ME-NBI) revealed different structures crypts and...
Abstract The pathological differential diagnosis between breast ductal carcinoma in situ (DCIS) and invasive (IDC) is of pivotal importance for determining optimum cancer treatment(s) clinical outcomes. Since conventional by pathologists using micro-scopes limited terms human resources, it necessary to develop new techniques that can rapidly accurately diagnose large numbers histopathological specimens. Computational pathology tools which assist detecting classifying DCIS IDC from whole...
Prostate cancer is often a slowly progressive indolent disease. Unnecessary treatments from overdiagnosis are significant concern, particularly low-grade Active surveillance has being considered as risk management strategy to avoid potential side effects by unnecessary radical treatment. In 2016, American Society of Clinical Oncology (ASCO) endorsed the Cancer Care Ontario (CCO) Practice Guideline on active for localized prostate cancer.Based this guideline, we developed deep learning model...
Abstract Background and study aims Gastric adenocarcinoma of the fundic gland type (GA-FG) is characterized by an elevated lesion with vessel dilation exhibiting branching architecture (DVBA). However, this feature also found in polyps (FGPs), posing a challenge their differentiation. In study, we aimed to investigate clinicopathological features gastric lesions DVBA assess efficacy white ring sign (WRS) as novel marker for distinguishing between FGPs GA-FGs. Methods We analyzed 159 without...
Abstract Clear cell sarcoma‐like tumor of the gastrointestinal tract (CCSLGT) is an extremely rare malignant neoplasm in digestive tract. Its cytomorphologic features have never previously been reported. Here, we describe a case CCSLGT, including its cytologic examination findings. A 47‐year‐old woman presented with mass small intestine, which was resected and sent for imprint cytology. Imprint smears revealed cells light eosinophilic or clear cytoplasm necrotic background. Many were...
Abstract Previous studies have indicated a possible relationship between increased prostate volume ( PV ) and decreased biopsy yield, although the mechanism involved is unclear. We evaluated 1650 patients who underwent template biopsy. The distribution of 993 cancer lesions in 302 prostatectomy specimens was compared with data to determine whether each lesion detected. A receiver operating characteristic ROC model used diagnostic accuracy prostate‐specific antigen PSA related markers....