A5033481594- Fibroblast Growth Factor Research
- Proteoglycans and glycosaminoglycans research
- Neurobiology and Insect Physiology Research
- Cervical Cancer and HPV Research
- Olfactory and Sensory Function Studies
- AI in cancer detection
- Glycosylation and Glycoproteins Research
- Catalysis for Biomass Conversion
- Colorectal Cancer Screening and Detection
- melanin and skin pigmentation
- Biofuel production and bioconversion
- Connective tissue disorders research
- Enzyme Catalysis and Immobilization
- Circadian rhythm and melatonin
- Retinal Development and Disorders
The University of Tokyo
2023-2025
Ochanomizu University
2023
Otsuka (Japan)
2023
Sapporo Kosei General Hospital
2022
Okayama University
2019
The recent discovery of nonvisual photoreceptors in various organs has raised expectations for uncovering their roles and underlying mechanisms. In this work, we identified a previously unrecognized hormone-releasing mechanism the pituitary Japanese rice fish (medaka) induced by light. Ca 2+ imaging analysis revealed that melanotrophs, type endocrine cell secretes melanocyte-stimulating hormone, robustly increase concentration intracellular during short-wavelength light exposure. Moreover,...
Liquid-based cytology (LBC) for cervical cancer screening is now more common than the conventional smears, which when digitised from glass slides into whole-slide images (WSIs), opens up possibility of artificial intelligence (AI)-based automated image analysis. Since processes by cytoscreeners and cytopathologists using microscopes limited in terms human resources, it important to develop new computational techniques that can automatically rapidly diagnose a large amount specimens without...
Abstract In addition to canonical photoreception by the eye, many other organs express non-visual photoreceptors although their biological significance is mostly unknown. Here, we discovered a novel phenomenon in which pituitary of medaka directly receives light, induces hormone release. Ca 2+ imaging analysis revealed that melanotroph, endocrine cell secreting melanocyte-stimulating (MSH), robustly increases [Ca ] i during short-wavelength light irradiation. Moreover, identified Opn5m as...
The hydrolysis of disaccharides was conducted using a microcapillary system under hydrothermal conditions (up to 190°C at 10 MPa and pH 4–11). reaction showed sigmoidal progression with time, especially alkaline conditions. Analysis kinetic model yielded the induction period. specific value (pH amb ) which is corresponding disaccharide hydrolysis, peculiar each disaccharide. Finally, calculation electron density around oxygen atom glycosidic bond between saccharides found roughly predict...
To analyze the role of syndecan-3 (SDC3), a heparan sulfate proteoglycan, in development cerebellum, we examined effect SDC3 on transition from cell cycle exit into initial differentiation stage cerebellar granule precursors (CGCPs). First, localization developing cerebellum. was mainly localized to inner external layer where CGCPs occurs. Next, performed SDC3-knockdown (KD) and overexpression assays using primary CGCPs. SDC3-KD significantly reduced ratio p27Kip1+ cells total cells....