A5100734045- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- Cancer Research and Treatments
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- Viral Infections and Immunology Research
- Signaling Pathways in Disease
- Graphene and Nanomaterials Applications
- Immune cells in cancer
Guangxi Medical University
2016-2025
Jiangsu Academy of Agricultural Sciences
2019-2025
Theranostics (New Zealand)
2019-2025
Yangzhou University
2019-2025
Ministry of Science ICT and Future Planning
2025
Ministère de l'Agriculture et de la Souveraineté alimentaire
2025
The Sixth People's Hospital of Shenyang
2024
Fuzhou University
2024
Zunyi Medical University
2023
Beijing Zhongke Science and Technology (China)
2023
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Hypoxia as one characteristic hallmark of solid tumors has been demonstrated to be involved in cancer metastasis and progression, induce severe resistance oxygen-dependent therapies, hamper the transportation theranostic agents. To address these issues, an oxygen-self-produced sonodynamic therapy (SDT) nanoplatform involving a modified fluorocarbon (FC)-chain-mediated oxygen delivery protocol established realize highly efficient SDT against hypoxic pancreatic cancer. In this nanoplatform,...
Abstract Suffering from the laborious synthesis and undesirable tumor microenvironment response, exploitation of novel NIR‐II absorbing organic photothermal agents is importance to promote phototherapeutic efficacy. Herein, two kinds charge‐transfer complex nanoparticles (TMB‐F4TCNQ TMB‐TCNQ) are prepared by supramolecular assembly. Because larger energy gap between donor acceptor, TMB‐F4TCNQ presents higher degree (72 %) than that TMB‐TCNQ (48 in nanoaggregates. Therefore, exhibits stronger...
Exosomes are membrane nanovesicles carrying molecular information that may reflect the biological and genetic characteristics of their parent cells.
Abstract The current feasibility of nanocatalysts in clinical anti-infection therapy, especially for drug-resistant bacteria infection is extremely restrained because the insufficient reactive oxygen generation. Herein, a novel Ag/Bi 2 MoO 6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized solvothermal reaction photoreduction. Ag/BMO held satisfactory bactericidal...
Small interfering RNA (siRNA) therapeutic is considered to be a promising modality for the treatment of hyperlipidemia. Establishment thermostable clinically applicable delivery system remains most challenging issue siRNA drug development. Here, series ionizable lipid-like materials were rationally designed; 4 panels lipid formulations fabricated and evaluated on basis four representative structures. The lead (A1-D1-5) was stable at 40°C, optimized formulation (iLAND) showed dose time...
LSD1 is a critical chromatin modulator that controls cellular pluripotency and differentiation through the demethylation of H3K4me1/2. Overexpression has been observed in many types tumors correlated with its oncogenic effects tumorigenesis. However, mechanism leading to upregulation remains unclear. Using an unbiased siRNA screening against all human deubiquitinases, we identified USP28 as bona fide deubiquitinase LSD1. interacted stabilized via deubiquitination. overexpression multiple...
Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). γδ T cells, a small subset of regulate the inflammation process many diseases, yet their function SCI is still poorly understood. In this paper, we demonstrate that mice deficient cells (TCRδ−/−) showed improved functional recovery after SCI. detected at lesion sites within 24 hours predominantly Vγ4 subtype express inflammatory cytokine IFN-γ. Inactivating IFN-γ signaling macrophages results...
DNA alkylating agents generally kill tumor cells by covalently binding with to form interstrand or intrastrand cross-links. However, in the case of cisplatin, only a few adducts (<1%) are highly toxic irreparable Furthermore, cisplatin is rapidly detoxified high levels intracellular thiols such as glutathione (GSH). Since discovery its mechanism action, people have been looking for ways directly and efficiently remove GSH increase cross-links improve drug efficacy overcome resistance, but...
Efficient endosomal escape is the most essential but challenging issue for siRNA drug development. Herein, a series of quaternary ammonium-based amphiphilic triblock polymers harnessing an elaborately tailored pH-sensitive hydrophobic core were synthesized and screened. Upon incubating in pH environment (pH 6.5–6.8), mPEG45-P(DPA50-co-DMAEMA56)-PT53 (PDDT, optimized polymer) nanomicelles (PDDT-Ms) PDDT-Ms/siRNA polyplexes rapidly disassembled, leading to promoted cytosolic release...
Nanochemotherapy combats cisplatin resistance by exploiting increased intracellular hypoxia in cancer cells.
Abstract Immunological adjuvants are essential for successful cancer vaccination. However, traditional have some limitations, such as lack of controllability and induction systemic toxicity, which restrict their broad application. Here, we present a light-activable immunological adjuvant (LIA), is composed hypoxia-responsive amphiphilic dendrimer nanoparticle loaded with chlorin e6. Under irradiation near-infrared light, the LIA not only induces tumour cell lysis antigen release, but also...