A5065762239- Nanowire Synthesis and Applications
- RNA Interference and Gene Delivery
- 2D Materials and Applications
- Advanced biosensing and bioanalysis techniques
- Hydrocarbon exploration and reservoir analysis
- Quantum Dots Synthesis And Properties
- Nanoplatforms for cancer theranostics
- Geological and Geophysical Studies
- Photonic and Optical Devices
- Luminescence and Fluorescent Materials
- Perovskite Materials and Applications
- Nanoparticle-Based Drug Delivery
- Gas Sensing Nanomaterials and Sensors
- Extracellular vesicles in disease
- Organic Light-Emitting Diodes Research
- Chalcogenide Semiconductor Thin Films
- Molecular Sensors and Ion Detection
- MXene and MAX Phase Materials
- Virus-based gene therapy research
- Photonic Crystals and Applications
- Immunotherapy and Immune Responses
- Graphene research and applications
- Monoclonal and Polyclonal Antibodies Research
- Geological Studies and Exploration
- Microfluidic and Capillary Electrophoresis Applications
Shanghai Ocean University
2012-2025
Southern Medical University
2022-2025
Chinese Academy of Sciences
2023-2025
Dongguan People’s Hospital
2025
Shanghai Institute of Materia Medica
2025
Harbin Institute of Technology
2020-2024
Tianjin University of Technology
2024
Beijing Institute of Technology
2015-2024
The University of Texas MD Anderson Cancer Center
2023-2024
Hebei University of Science and Technology
2023-2024
Organic materials with long-lived, color-tunable phosphorescence are potentially useful for optical recording, anti-counterfeiting, and bioimaging. Herein, we develop a series of novel host-guest organic phosphors allowing dynamic color tuning from the cyan (502 nm) to orange red (608 nm). Guest employed tune phosphorescent color, while host interact guest activate emission. These have an ultra-long lifetime 0.7 s maximum efficiency 18.2 %. Although inks already been developed using visible...
Organic room temperature phosphorescence (RTP) materials have been used in high resolution imaging and anticounterfeiting due to their long lifetime of ability avoid interference from autofluorescence excitation light. An important factor when considering is the constant intersystem crossing (ISC) process. It great importance develop novel pure organic RTP via precise manipulation ISC process nonradiative decay rate. Encapsulation a luminophore host matrix can quenching caused by presence...
Polarization-sensitive photodetectors are highly desirable for high-performance optical signal capture and stray light shielding in order to enhance the capability detection identification of targets dark, haze, other complex environments. Usually, filters polarizers utilized conventional devices achieve polarization-sensitive detection. Herein, simplify system, a two-dimensional self-powered photodetector is fabricated based on stacked GeSe/MoS2 van der Waals (vdW) heterojunction which...
One of the imperative medical requirements for cancer treatment is how to establish an imaging-guided nanocarrier that combines therapeutic and imaging agents into one system. siRNA therapeutics have shown promising prospects in controlling life-threatening diseases. However, it still challenging develop formulations with excellent cellular entry capability, efficient endosomal escape, simultaneous visualization. Herein, we fabricated multifunctional ionizable lipid nanoparticles (iLNPs)...
Ferroptosis therapy (FT) efficacy of tumors suffers from a relatively low concentration Fenton agents, limited hydrogen peroxide (H2O2) content, and insufficient acidity in the tumor environment (TME), which are unfavorable for reactive oxygen species (ROS) generation based on or Fenton-like reactions. The glutathione (GSH) overexpression TME can scavenge ROS abate FT performance. In this study, strategy storm specifically initiated by our developed nanoplatforms (TAF-HMON-CuP@PPDG) is...
A series of poly(1,4-dihydropyridine)s (PDHPs) were successfully synthesized via one-pot metal-free multicomponent polymerization diacetylenic esters, benzaldehyde, and aniline derivatives. These PDHPs without traditional luminescent units endowed with tunable triplet energy levels by through-space conjugation from the formation different cluster sizes. The large compact clusters can effectively extend phosphorescence wavelength. excitons be stabilized using benzophenone as a rigid matrix to...
Small interfering RNA (siRNA) therapeutic is considered to be a promising modality for the treatment of hyperlipidemia. Establishment thermostable clinically applicable delivery system remains most challenging issue siRNA drug development. Here, series ionizable lipid-like materials were rationally designed; 4 panels lipid formulations fabricated and evaluated on basis four representative structures. The lead (A1-D1-5) was stable at 40°C, optimized formulation (iLAND) showed dose time...
Abstract The immunosuppressive microenvironment of glioblastoma multiforme (GBM) severely impacts the response to various treatments, including systemic chemotherapy. Targeted reprogramming GBM using RNA interference (RNAi) is largely restricted by poor brain delivery efficiency and targeting specificity. Herein, an acid‐cleavable transferrin (Tf) decorated engineering exosome‐based brain‐targeting system (ACTE) was proposed efficiently deliver small towards transform growth factor‐β...
Efficient endosomal escape is the most essential but challenging issue for siRNA drug development. Herein, a series of quaternary ammonium-based amphiphilic triblock polymers harnessing an elaborately tailored pH-sensitive hydrophobic core were synthesized and screened. Upon incubating in pH environment (pH 6.5–6.8), mPEG45-P(DPA50-co-DMAEMA56)-PT53 (PDDT, optimized polymer) nanomicelles (PDDT-Ms) PDDT-Ms/siRNA polyplexes rapidly disassembled, leading to promoted cytosolic release...
Exosomes derived from natural killer (NK) cells (NEO) constitute promising antineoplastic nano-biologics because of their versatile functions in immune regulation. However, a significant augment immunomodulatory capability is an essential need to achieve clinically meaningful treatment outcomes. Light-activatable silencing NK-derived exosomes (LASNEO) are orchestrated by engineering the NEO with hydrophilic small interfering RNA (siRNA) and hydrophobic photosensitizer Ce6. Profiling genes...
Open AccessCCS ChemistryCOMMUNICATION5 Aug 2022Red-Emissive Organic Room-Temperature Phosphorescence Material for Time-Resolved Luminescence Bioimaging Wenbo Dai†, Yahui Zhang†, Xinghui Wu, Shuai Guo, Jieran Ma, Jianbing Shi, Bin Tong, Zhengxu Cai, Haiyan Xie and Yuping Dong Dai† Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials Green Applications, School Science Engineering, Institute Technology, 100081 †W. Dai Y. Zhang contributed equally to this work.Google...
Abstract To surmount the major concerns of commercial small molecule Gd chelates and reported Gd‐based contrast agents (GBCAs) for magnetic resonance imaging (MRI), a new concept organogadolinium macrochelates (OGMCs) constructed from coordination between 3+ macromolecules is proposed. A library were screened coordination, two candidates [i.e., poly(acrylic acid) (PAA), poly(aspartic (PASP)] succeeded in OGMC formation. Under optimized synthesis conditions, both Gd‐PAA12 Gd‐PASP11 OGMCs are...
Abstract The integration of nanomedicine and immunotherapy has presented a promising opportunity for the treatment cancer diverse diseases. However, achieving spatiotemporal controllable with excellent efficacy safety performances remains significant challenge. This study develops biodegradable near‐infrared II (NIR‐II) photothermal response polymer nanoparticle (PTEQ) system. platform exhibits intrinsic immunostimulatory properties while concurrently delivering siRNA Programmed Death‐Ligand...
Hyperuricemia is associated with an increased risk of gout, hypertension, diabetes, and cardiovascular diseases. Most mammals maintain normal serum uric acid (SUA) via urate oxidase (Uox), enzyme that metabolizes poorly-soluble UA to highly-soluble allantoin. In contrast, Uox became a pseudogene in humans apes over the long course evolution. Here we demonstrate atavistic strategy for treating hyperuricemia based on endogenous expression hepatocytes mediated by mRNA (mUox) loaded ionizable...
WNT/β-catenin signaling plays key roles in development and cancer1,2. ZNRF3/RNF43 modulates Frizzleds through ubiquitination, dampening signaling. Conversely, RSPO1-4 binding to LGR4-6 enhances signaling3–5. Here, we elucidate the overall landscape of architectures multiple LGR4, RSPO2, ZNRF3 assemblies, showcasing varying stoichiometries arrangements. These structures reveal that LGR4 RSPO2 capture distinct states ZNRF3. The intrinsic heterogeneity LGR4-RSPO2-ZNRF3 assembly is influenced by...
Although the combination of radiotherapy and immunotherapy is regarded as a promising clinical treatment strategy, numerous trials have failed to demonstrate synergistic effects. One key reasons that conventional radiotherapies inevitably damage intratumoral effector immune cells. Boron Neutron Capture Therapy (BNCT) precise selectively kills tumor cells while sparing adjacent normal cells, by utilizing 10B agents neutron irradiation. Therefore, combinational BNCT-immunotherapy holds promise...
Small interfering RNA (siRNA) shows excellent pharmaceutical prospects in treating diverse life-threatening diseases. Photodynamic therapy (PDT) is a clinically employed noninvasive treatment method that can trigger selective damage toward targeted tissue and cells. However, insufficient delivery of siRNA photosensitizer to cancer cells remarkably hindered the application PDT cancer. In this study, unique reactive oxygen species (ROS)-activatable polyplex, which consists PEGylated cationic...
CRISPR/Cas9-based gene editing has emerged as a powerful biotechnological tool, that relies on Cas9 protein and single guided RNA (sgRNA) to edit target DNA. However, the lack of safe efficient delivery carrier is one crucial factors restricting its clinical transformation. Here, we report an ionizable lipid nanoparticle (iLP181, pKa = 6.43) based iLY1809 enabling robust in vitro vivo. The iLP181 effectively encapsulate psgPLK1, best-performing plasmid expressing for both sgRNA targeting...
Abstract Organic materials with long‐lived, color‐tunable phosphorescence are potentially useful for optical recording, anti‐counterfeiting, and bioimaging. Herein, we develop a series of novel host–guest organic phosphors allowing dynamic color tuning from the cyan (502 nm) to orange red (608 nm). Guest employed tune phosphorescent color, while host interact guest activate emission. These have an ultra‐long lifetime 0.7 s maximum efficiency 18.2 %. Although inks already been developed using...
Abstract A prevalent problem of magnetic resonance imaging (MRI) contrast agents (CAs) for drug loading applications is easy aggregation. The major concern hollow mesoporous organosilica nanoparticles (HMONs) hard control untimely leakage. To overcome both problems, a new strategy limited‐space controlled aggregation generic enhancement capability proposed. Typically, MRI CAs exceedingly small gadolinium oxide nanoparticle (GO) and Gd poly(acrylic acid) macrochelate (GP) are exploited to...
Cancer stem cells (CSCs) are one of the determinants tumor heterogeneity and characterized by self-renewal, high tumorigenicity, invasiveness, resistance to various therapies. To overcome traditional therapies resulting from CSCs, a strategy double drug sequential therapy (DDST) for CSC-enriched tumors is proposed in this study realized utilizing developed double-layered hollow mesoporous cuprous oxide nanoparticles (DL-HMCONs). The drug-loading contents camptothecin (CPT) all-trans retinoic...