A5103070538- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Gut microbiota and health
- Cancer Research and Treatments
- Biosensors and Analytical Detection
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- COVID-19 Clinical Research Studies
- Animal Nutrition and Physiology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- RNA Research and Splicing
- Cancer-related gene regulation
- Drug Transport and Resistance Mechanisms
- Sinusitis and nasal conditions
- COVID-19 epidemiological studies
- Clostridium difficile and Clostridium perfringens research
- Asthma and respiratory diseases
- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
- Sepsis Diagnosis and Treatment
Sun Yat-sen University
2024
Chinese University of Hong Kong
2006-2023
University of Hong Kong
2008-2023
City University of Hong Kong, Shenzhen Research Institute
2022-2023
Chinese University of Hong Kong, Shenzhen
2016-2021
Huazhong University of Science and Technology
2005-2018
Public Health Agency
2017
University of Birmingham
2017
Northeast Agricultural University
2014-2016
Harbin Medical University
2014
Background & AimsPatients with colorectal cancer (CRC) have a different gut microbiome signature than individuals without CRC. Little is known about the viral component of CRC-associated microbiome. We aimed to identify and validate taxonomic markers CRC that might be used in detection disease or predicting outcome.MethodsWe performed shotgun metagenomic analyses viromes fecal samples from 74 patients (cases) 92 (controls) Hong Kong (discovery cohort). Viral sequences were classified by...
Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C. reduces intestinal tumor formation two murine CRC models a female-specific manner. Estrogen increases the attachment and colonization via increasing colonic expression SLC3A2 that binds DD-CPase this bacterium. Metabolomic transcriptomic profiling unveils increased gut abundance vitamin D-related metabolites mucosal activation D receptor (VDR) signaling...
Abstract Background Altered microbiome composition and aberrant promoter hypermethylation of tumor suppressor genes (TSGs) are two important hallmarks colorectal cancer (CRC). Here we performed concurrent 16S rRNA gene sequencing methyl-CpG binding domain-based capture in 33 tissue biopsies (5 normal colonic mucosa tissues, 4 pairs adenoma adenoma-adjacent 10 CRC CRC-adjacent tissues) to identify significant associations between TSG CRC-associated bacteria, followed by functional validation...
BackgroundViral infections of the respiratory tract represent a major global health concern. Co-infection with bacteria may contribute to severe disease and increased mortality in patients. Nevertheless, viral-bacterial co-infection patterns their clinical outcomes have not been well characterized date. This study aimed evaluate features patients co-infections.MethodsWe included 19,361 infection due viruses [influenza A B, syncytial virus (RSV), parainfluenza] and/or four tertiary hospitals...
Recent studies have reported numerous predictors for adverse outcomes in COVID-19 disease. However, there been few simple clinical risk scores available prompt stratification. The objective is to develop a score predicting severe disease using territory-wide data based on and laboratory variables. Consecutive patients admitted Hong Kong's public hospitals between 1 January 22 August 2020 diagnosed with COVID-19, as confirmed by RT-PCR, were included. primary outcome was composite intensive...
Clostridioides difficile infection (CDI) is a common cause of nosocomial diarrhea. TcdB major C. exotoxin that activates macrophages to promote inflammation and epithelial damage. Lysosome impairment known trigger for inflammation. Herein, we hypothesize could impair macrophage lysosomal function mediate during CDI. Effects on the downstream pro-inflammatory SQSTM1/p62-NFKB (nuclear factor kappa B) signaling were assessed in cultured murine CDI model. Protective effects two lysosome...
Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections Asia than Europe North America. The temporal C. infection is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden clinical outcomes Hong Kong, China, over 9-year period. A total 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated 817 (5.1%) community-associated...
OBJECTIVE Stress hyperglycemia is associated with an increased risk of diabetes among survivors critical illness. We investigated whether patients without hospitalized for bacteremia or nonbacteremic diseases transient stress would have a higher subsequent development compared those who remained normoglycemic. RESEARCH DESIGN AND METHODS This retrospective observational study was conducted on 224,534 in-patients blood culture records. defined based the highest random glucose level ≥7.8...
Real-world epidemiological data on the risk of tuberculosis (TB) in patients with immune-mediated diseases treated biologics are scarce TB endemic areas. We investigated incidence a population-based setting and stratified among different biological therapies.We collected medical from territory-wide computerized database Hong Kong. reported various classes biologics, calculated standardized ratio by comparing general population. Subgroup analyses were performed based disease subtypes...
AIM:To investigate the effect of CpG-containing oligodeoxynucleotides (CpG ODN) alone or in combination with chemotherapeutic agent 5-fluorouracil (5-FU) on tumor growth and whether CpG ODN can reverse immunosuppression caused by chemotherapy 5-FU murine hepatoma model. METHODS:Hepatoma model was established subcutaneous inoculation hepatoma-22 (H 22 ) cells into right flank BALB/c mice.Mice were treated peritumoral injection 5-FU.Tumor size quantified regularly.Serum levels IL-12 IF N-...
Focal copy number gains or losses are important genomic hallmarks of cancer. The distribution oncogenes and tumor-suppressor genes (TSG) in relation to focal aberrations is unclear. Our analysis revealed that the mean distance TSGs from was significantly shorter than noncancer genes, suggesting tend be close physical proximity human genome. Such relationship conserved mouse drosophila. Pan-cancer using data Cancer Genome Atlas indicated without a nearby TSG more prone amplification. In...
Tumor suppressor genes (TSGs) exhibit distinct evolutionary features. We speculated that TSG promoters could have evolved specific features facilitate their tumor-suppressing functions. found the promoter CpG dinucleotide frequencies of TSGs are significantly higher than non-cancer across vertebrate genomes, and positively correlated with gene expression tissue types. The all gradually increase age, for which young been subject to a stronger pressure. Transcription-related features, namely...
Normalization of array data relies on the assumption that most genes are not altered, which means signals for different samples should be scaled to have similar median or average values. However, accumulating evidence suggests gene expression could widely up-regulated in cancers. Our previous results and subsequent findings shown violation led erroneous interpretation microarray data. To decipher global signal features from cancer samples, we empirically evaluated a large collection miRNA...
Different inflammatory reactions have been observed in the polyp tissues of nonsmokers and smokers with chronic rhinosinusitis (CRS). E-prostanoid (EP) receptors play a role processes. Cigarette smoke (CS) exposure regulates EP-receptor expression levels promoting mediator release from various cells. In this study, we characterize profiles polyps nonsmoking smoking CRS patients to explore possible CS pathogenesis nasal (CRSwNP).Polyp biopsies were obtained 28 non-smoking 21 CRSwNP patients....