A5101881515- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Helicobacter pylori-related gastroenterology studies
- Cancer Genomics and Diagnostics
- Gut microbiota and health
- Antimicrobial Peptides and Activities
- RNA modifications and cancer
- Clostridium difficile and Clostridium perfringens research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Respiratory viral infections research
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Vitamin D Research Studies
- Pancreatic and Hepatic Oncology Research
- Job Satisfaction and Organizational Behavior
- Pediatric health and respiratory diseases
- Probiotics and Fermented Foods
- Infant Nutrition and Health
- Clinical practice guidelines implementation
Southern Medical University Shenzhen Hospital
2018-2024
Third Affiliated Hospital of Southern Medical University
2024
Plant & Food Research
2024
Nanjing Agricultural University
2024
Chinese University of Hong Kong
2016-2022
Beijing Fengtai Hospital
2020
Anhui Medical University
2020
Air Force Medical University
2018
Chongqing Medical University
2014
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014
To investigate the relationship between job satisfaction, work stress, work-family conflict and turnover intention, explore factors associated with among physicians in Guangdong Province, China.From August to October 2013, completed questionnaires scales regard their conflict, intention. Binary logistic regression structural equation modelling (SEM) were used data analysis.A total of 3963 approached, 3563 completing questionnaire. The mean score overall perception intention who worked was...
A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant viral pathogenicity. Here, by transcriptome analysis, we demonstrated inflammasome-related NOD-like receptor signaling was activated in SARS-CoV-2-infected lung epithelial cells and Disease 2019 (COVID-19) patients' tissues. The induction inflammasomes/pyroptosis patients with severe COVID-19 confirmed serological markers....
Objectives This cross-sectional study aimed to explore job satisfaction among healthcare staff in Guangdong following the health system reforms 2009, and investigate association between work stress, work–family conflict doctor–patient relationship. Design Cross-sectional survey. Setting The Fifth National Health Service Survey was carried out Guangdong, China. Participants All participants this were including physicians, nurses public from hospitals, service centres clinics. A total of 6583...
Helicobacter pylori (H. pylori) is a common human pathogenic bacterium. Once infected, it difficult for the host to clear this organism using innate immune system. Increased antibiotic resistance further makes challenging effective eradication. However, mechanisms of evasion still remain obscure, and novel strategies should be developed efficiently eliminate H. infection in stomachs. Here we uncovered desirable anti-H. effect vitamin D3 both vitro vivo, even against antibiotic-resistant...
Rationale: Methylation at the N6 position of adenosine (m6A) is most prevalent RNA modification within protein-coding mRNAs in mammals, and it a reversible with various important biological functions. The formation function m6A are regulated by methyltransferases (writers), demethylases (erasers), special binding proteins (readers) as key factors. However, underlying mechanisms gastrointestinal (GI) cancer remain unclear. Here, we performed comprehensive molecular profiling nine known...
BackgroundViral infections of the respiratory tract represent a major global health concern. Co-infection with bacteria may contribute to severe disease and increased mortality in patients. Nevertheless, viral-bacterial co-infection patterns their clinical outcomes have not been well characterized date. This study aimed evaluate features patients co-infections.MethodsWe included 19,361 infection due viruses [influenza A B, syncytial virus (RSV), parainfluenza] and/or four tertiary hospitals...
Abstract The role of N 6 -methyladenosine (m A) modification host mRNA during bacterial infection is unclear. Here, we show that Helicobacter pylori upregulates m A methylases and increases levels in gastric epithelial cells. Reducing methylase activity via hemizygotic deletion methylase-encoding gene Mettl3 mice, or small interfering RNAs targeting methylases, enhances H. colonization. We identify LOX-1 as a key A-regulated target infection. destabilizes reduces protein levels. acts...
Abstract Impaired autophagic degradation of intracellular lipids is causally linked to the development non‐alcoholic steatohepatitis (NASH). Pharmacological agents that can restore hepatic flux could therefore have therapeutic potentials for this increasingly prevalent disease. Herein, we investigated effects polydatin, a natural precursor resveratrol, in murine nutritional model NASH and cell line steatosis. Results showed oral administration polydatin protected against lipid accumulation...
Abstract The antimicrobial peptide cathelicidin is critical for protection against different kinds of microbial infection. This study sought to elucidate the protective action Helicobacter pylori infection and its associated gastritis. Exogenous was found inhibit H. growth, destroy bacteria biofilm, induce morphological alterations in membrane. Additionally, knockdown endogenous human gastric epithelial HFE-145 cells markedly increased intracellular survival pylori. Consistently, knockout...
The intestinal epithelium compartmentalizes the sterile bloodstream and commensal bacteria in gut. Accumulating evidence suggests that this barrier is impaired sepsis, aggravating systemic inflammation. Previous studies reported cathelicidin differentially expressed various tissues sepsis. However, its role sepsis-induced dysfunction has not been investigated.To examine of polymicrobial wild-(Cnlp+/+) knockout (Cnlp-/-) mice underwent cecal-ligation puncture (CLP) followed by assessment...
Clostridioides difficile infection (CDI) is a common cause of nosocomial diarrhea. TcdB major C. exotoxin that activates macrophages to promote inflammation and epithelial damage. Lysosome impairment known trigger for inflammation. Herein, we hypothesize could impair macrophage lysosomal function mediate during CDI. Effects on the downstream pro-inflammatory SQSTM1/p62-NFKB (nuclear factor kappa B) signaling were assessed in cultured murine CDI model. Protective effects two lysosome...
Through the combined use of two nitrification inhibitors, Dicyandiamide (DCD) and chlorate with nitrogen amendment, this study aimed to investigate contribution comammox
Helicobacter pylori (H. pylori) manipulates the host immune system to establish a persistent colonization, posing serious threat human health, but mechanisms remain poorly understood. Here we integrate single-cell RNA sequencing and TCR profiling for analyzing 187,192 cells from 11 H. pylori-negative 12 pylori-positive individuals describe gastric ecosystem reprogrammed by infection, as manifested impaired antigen presentation phagocytosis function. We further delineate monocyte-to-C1QC+...
Evasion of autophagy is key for intracellular survival bacteria in host cells, but its involvement persistent infection by Helicobacter pylori, a bacterium identified to invade gastric epithelial remains obscure. The aim this study was functionally characterize the role H. pylori infection. Autophagy assayed pylori-infected human epithelium and functional determined via genetic or pharmacological ablation mouse cell line models Here, we showed that inhibited lysosomal function thereby...
Due to the high mortality rate and unsatisfactory treatment options available, hepatocellular carcinoma (HCC) remains one of most common malignancies a leading cause cancer-associated mortality. Novel therapeutic targets for HCC are urgently required. Advanced RNA sequencing technology enables identification considerable amounts noncoding RNAs (ncRNAs), including small long RNAs, which exhibit no protein-coding activities. In this respect, ncRNAs their regulatory processes important factors...
Background High-grade gliomas are rapidly progressing tumors of the central nervous system, and associated with poor prognosis highly immunosuppressive microenvironments. Meanwhile, a better understanding PD-L1, major prognostic biomarker for checkpoint immune therapy, regulation may provide insights developing novel immunotherapeutic strategies treating gliomas. In present study, we elucidate functional significance orphan nuclear receptor TLX in human glioma, its role suppression through...
Abstract Background and Aim The preventive effect of intrarectal administration mouse cathelicidin (mCRAMP) oral mCRAMP‐encoding Lactococcus lactis (N4I) has been shown in murine experimental colitis. It is pivotal to understand the ability N4I whether it can promote mucosal repair existing Methods Mice with dextran sulfate sodium‐induced ulcerative colitis (UC) were treated orally L. or its transformed strain without nisin induction. body weight, clinical symptoms, histological changes...