A5101771093- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Olfactory and Sensory Function Studies
- Traditional Chinese Medicine Studies
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Coaching Methods and Impact
- Neuropeptides and Animal Physiology
- Transcranial Magnetic Stimulation Studies
- Emotional Intelligence and Performance
- Vitamin C and Antioxidants Research
- Amino Acid Enzymes and Metabolism
- Mesenchymal stem cell research
- Neurological disorders and treatments
- Receptor Mechanisms and Signaling
- Immune cells in cancer
- Ophthalmology and Eye Disorders
- Chinese history and philosophy
- User Authentication and Security Systems
- Neurogenesis and neuroplasticity mechanisms
- Pharmaceutical industry and healthcare
- Hair Growth and Disorders
- Food Chemistry and Fat Analysis
- Pathogenesis and Treatment of Hiccups
Chinese PLA General Hospital
2016-2024
Wenzhou Medical University
2024
Takeda (United States)
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Southern Medical University Shenzhen Hospital
2021
Third Affiliated Hospital of Southern Medical University
2021
PLA Academy of Military Science
2021
Shanghai Jiao Tong University
2020-2021
Nanjing University of Posts and Telecommunications
2018
East China Normal University
2018
The oxidative balance score (OBS), an encompassing scoring mechanism for assessing stress, is formulated based on nutritional and lifestyle components. emergence of metabolic syndrome (MetS) intricately linked to stress. Nonetheless, the correlation between OBS MetS displays variability within distinct cohorts.
With the rapid development of wearable biosensors and wireless communication technologies, various smart healthcare systems are proposed to monitor health patients in real time. However, many security problems exist these systems. For example, a password guessing attack can compromise IoT devices, leading invasion data privacy. After giving an overview threats IoT, this article studies vulnerabilities building presents strength evaluation method that takes into account users' personal information.
Objective Although nociceptive sensitisation is an important pathophysiological process in migraine and chronification, its underlying mechanisms remain unclear. Toll-like receptor 4 (TLR4), a pattern-recognition molecule, has critical role both neuropathic pain morphine tolerance. The present study examined whether elements of the TLR4 pathway contribute to hyperalgesia induced by dural inflammation rats. Methods A rat model was established infusing inflammatory soup. group pretreated with...
The complex preparation procedures and severe toxicities are two major obstacles facing the wide use of chimeric antigen receptor-modified T (CAR-T) cells in clinical cancer immunotherapy. nanotechnology-based cell temporary CAR modification may be a potential approach to solve these problems make CAR-T cell-based tumor therapy feasible broadly applicable.A series plasmid DNA-loaded self-assembled nanoparticles (pDNA@SNPsx/y) prepared from adamantane-grafted polyamidoamine (Ad-PAMAM)...
To observe the prevalence and characteristics of premonitory symptoms in Chinese migraineurs explore their associations with migraine-related factors.Migraineurs who visited a tertiary headache clinic one nine neurology clinics between May 2014 November 2019 were studied.Among 4821 patients meeting migraine criteria (International Classification Headache Disorders, 3rd edition), 1038 (21.5%) experienced at least symptom. The most common neck stiffness, dizziness, yawning drowsiness. logistic...
Abstract Background We show previously that three-dimensional (3D) spheroid cultured mesenchymal stem cells (MSCs) exhibit reduced cell size thus devoid of lung entrapment following intravenous (IV) infusion. In this study, we determined the therapeutic effect 3D-cultured MSCs on ischemic stroke and investigated mechanisms involved. Methods Rats underwent middle cerebral artery occlusion (MCAO) reperfusion. 1 × 10 6 3D- or 2D-cultured MSCs, which were pre-labeled with GFP, injected through...
Melittin is a potential anticancer candidate with remarkable antitumor activity and ability to overcome tumor drug resistance. However, the clinical applications of melittin are largely restricted by its severe hemolytic nonspecific cytotoxicity after systemic administration. Here, biocompatible stable melittin-loaded lipid-coated polymeric nanoparticle (MpG@LPN) formulation that contains melittin/poly-γ-glutamic acid inner core, lipid membrane middle layer, polyethylene glycol (PEG)...
Background Preclinical experimental studies revealed an acute alteration of pituitary adenylate cyclase-activating polypeptide in response to a single activation the trigeminovascular system, which suggests potential role pathogenesis migraine. However, changes after repeated migraine-like attacks chronic migraine are not clear. Therefore, present study investigated and related receptors chemical dural stimulations rat. Methods A rat model was established by using inflammatory soup for...
Background High-grade gliomas are rapidly progressing tumors of the central nervous system, and associated with poor prognosis highly immunosuppressive microenvironments. Meanwhile, a better understanding PD-L1, major prognostic biomarker for checkpoint immune therapy, regulation may provide insights developing novel immunotherapeutic strategies treating gliomas. In present study, we elucidate functional significance orphan nuclear receptor TLX in human glioma, its role suppression through...
Headache disorders are widely prevalent and pose a considerable economic burden on individuals society. Globally, misdiagnosis inadequate treatment of primary headache remain significant challenges, impeding the effective management such conditions. Despite advancements in over last decade, need for comprehensive evaluations status China regarding diagnosis preventative treatments persists.In present study, we analyzed established queries Survey Fibromyalgia Comorbidity with (SEARCH),...
Abstract The effect of food composition, tablet crushing, and antacid coadministration on maribavir pharmacokinetics was assessed in 2 Phase 1 studies healthy adults. In the first, a single 400‐mg dose administered under fasting conditions, with low‐fat/low‐calorie or high‐fat/high‐calorie meal. second, 100‐mg as crushed tablet, whole alone an antacid. 90% confidence intervals geometric mean ratios were within 80%‐125% for area concentration‐time curve (AUC), but not maximum plasma...
Migraine has been demonstrated to exhibit abnormal functional connectivity of large-scale brain networks, which is closely associated with its pathophysiology and not yet explored by edge connectivity. We used an edge-centric approach combined motif analysis evaluate higher-order communication patterns networks in migraine.
Clinical and preclinical studies have implicated serotonin (5-HT) the 5-HT2A receptor (5-HT2AR) in pathogenesis of medication-overuse headache (MOH). However, with no appropriate animal model to study this phenomenon it is difficult differentiate effects chronic exposure analgesics from consequences frequent attacks during development MOH. Therefore, used a novel MOH established by combination overuse rizatriptan (RIZ) stimulation dural inflammatory soup (IS) investigate whether 5-HT 5-HT2AR...
Although migraine is a major global public health problem, its impact on cognitive abilities remains controversial. Thus, the present study investigated effects of repeated administration inflammatory soup to dura rats, over three weeks, spatial cognition, hippocampal synaptic plasticity, and expression N-methyl-D-aspartate receptor subunits. Additionally, low doses amitriptyline (5 mg/kg) were applied assess therapeutic effects. The group exhibited significant reductions in cutaneous...
The aim of the study was to investigate whether MwoA and MwA are different manifestations a single disease, distinct clinical entities, or located at two poles spectrum.In this cross-sectional study, 5438 patients from 10 hospitals in China were included: 4651 diagnosed with migraine without aura (MwoA) 787 (MwA). We used validated standardized electronic survey collect multidimensional data on headache characteristics evaluated similarities differences between subtypes. To distinguish...
Abstract Oleogel with tailored viscoelasticity is a great interest for food structuring, while its potential benefits edible film performance are not clear. In this study, β‐sitosterol (0, 5, 10, 15, and 20 wt%)‐corn oil oleogel was developed used in the formation of gelatin‐based films. Importantly, adding significantly decreased water vapor permeability gelatin films, however, it had little negative influence on strength. addition, results study demonstrated that increasing sitosterol...
Abstract Background Tianshu capsule (TSC), a formula of traditional Chinese medicine, has been widely used in clinical practice for prophylactic treatment headaches China. However, former trials TSC were small, and lack standard set diagnostic criteria to enroll patients. The study was conducted re-evaluate the efficacy safety post-marketing an extending number migraineurs who have diagnosed migraine with International Classification Headache Disorders, 3rd edition (beta version, ICHD-3β)....
Abstract Background Mesenchymal stem cells (MSCs) have shown immense therapeutic potential for various brain diseases. Intrathecal administration of MSCs may enhance their recruitment to lesions in the central nervous system, but any impact on cerebrospinal fluid (CSF) flow remains unclear. Methods Rats with or without middle cerebral artery occlusion (MCAO) received intrathecal injections 2D cultured MSCs, 3D an equal volume artificial (ACSF). Ventricle was assessed by MRI Days 2 and 14...
Objective: Toutongning (TTN) capsule, a Chinese patent medicine, is used as prophylactic treatment for migraine. The present study was conducted postmarketing evaluation of the efficacy and safety TTN capsule. Design: A randomized, double-blind, placebo-controlled trial. Location: Patients recruited from 14 medical centers in China May 2014 to August 2015. Subjects: between 18 65 years age with diagnosis Interventions: patients were randomly assigned receive either (1200 mg, three times...
Abstract Background Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) short-lasting cranial autonomic symptoms (SUNA) have not been evaluated sufficiently due to limited data, particularly in China. Methods Patients SUNCT or SUNA treated a tertiary centre seven other clinics of China between April 2009 July 2022 were studied; we compared their demographics clinical phenotypes. Results The 45 patients 31 had mean ages at onset 37.22 ± 14.54...
The aims were to explore the prevalence and clinical features of fibromyalgia in Chinese hospital patients with primary headache.Studies done non-Chinese populations suggest that around one-third headache have fibromyalgia, but data from mainland China are limited. Investigations into would improve our understanding these two complex disease areas help guide future practice.This cross-sectional study included adults treated at 23 hospitals September 2020 May 2021. Fibromyalgia was diagnosed...