A5022118780- Kruppel-like factors research
- Phagocytosis and Immune Regulation
- Cell Adhesion Molecules Research
- FOXO transcription factor regulation
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Chronic Myeloid Leukemia Treatments
- Ginkgo biloba and Cashew Applications
- Cancer Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Air Quality and Health Impacts
- Advanced Glycation End Products research
- Transportation Planning and Optimization
- Medical Imaging Techniques and Applications
- Immune cells in cancer
- MRI in cancer diagnosis
- Neurological Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Mitochondrial Function and Pathology
- Natural Compounds in Disease Treatment
- Pancreatic function and diabetes
- Genetic and Kidney Cyst Diseases
- Nanoparticle-Based Drug Delivery
- Genomics and Chromatin Dynamics
Beihang University
2025
Ministry of Industry and Information Technology
2025
Southern Medical University Shenzhen Hospital
2017-2022
Third Affiliated Hospital of Southern Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Xiyuan Hospital
2018
Affiliated Hospital of Taishan Medical University
2018
SAIC Motor (China)
2017
Soochow University
2012
First Affiliated Hospital of Soochow University
2012
Polydatin (PD), a resveratrol glycoside, has been shown to protect renal function in diabetic nephropathy (DN), but the underlying molecular mechanism remains unclear. This study demonstrates that PD stabilize mitochondrial morphology and attenuate malfunction both KKAy mice hyperglycemia (HG)‐induced MPC5 cells. We use Western blot analysis demonstrate reversed podocyte apoptosis induced by HG via suppressing dynamin‐related protein 1 (Drp1). effect may depend on ability of inhibit...
The role of celastrol in the treatment cancer has been an area growing interest. To circumvent issues low solubility, poor bioavailability, and systemic toxicity celastrol, we prepared liposomal using thin-film dispersion method. We characterized particle size, encapsulation efficiency, pharmacological parameters celastrol. drug concentration plasma tissues was measured LC-MS/MS. In addition, sulforhodamine B assay used to determine 50% inhibiting concentration. assessed effects compound...
Early prediction of treatment response to neoadjuvant therapy (NAT) in breast cancer patients can facilitate timely adjustment regimens. We aimed develop and validate a MRI-based enhanced self-attention network (MESN) for predicting pathological complete (pCR) based on longitudinal images at the early stage NAT. Two imaging datasets were utilized: subset from ACRIN 6698 trial (dataset A, n = 227) prospective collection Chinese hospital B, 245). These divided into three cohorts: an training...
Background High-grade gliomas are rapidly progressing tumors of the central nervous system, and associated with poor prognosis highly immunosuppressive microenvironments. Meanwhile, a better understanding PD-L1, major prognostic biomarker for checkpoint immune therapy, regulation may provide insights developing novel immunotherapeutic strategies treating gliomas. In present study, we elucidate functional significance orphan nuclear receptor TLX in human glioma, its role suppression through...
Acute myocardial infarction (AMI) is one of the most threaten disease in world. Ginkgetin aglycone (GA) was a new kind Ginkgo biloba, involved various diseases, including kidney injury and acute pancreatitis. However, function GA AMI remains unknown. The aim study to investigate characteristics ischemic-reperfusion injury.H2 O 2 - CoCl -treated H9C2 cells were used analyze vitro. Caspase 3, interleukin-6 (IL-6), tumor necrosis factor-α detected evaluate apoptosis inflammation response. Rat...
Abstract Our previous study illustrated that nuclear factor IX (NFIX) promotes glioblastoma (GBM) progression by inducing migration and proliferation of GBM cells. However, the underlying mechanism how NFIX regulates cell remains obscure. In this study, we uncovered Go-Ichi-Ni-San 1 (GINS1) is upregulated positively correlated with in human specimen. silencing downregulates expression GINS1, which pivotal for cell-cycle Replenishment GINS1 largely rescues NFIX-null effect on proliferation....
<p>S1. Full images of immunoblotting. S2. NFIX knockdown has no effect on p53 and p21 expression. S3. Knockdown GINS1 by shRNAs in U87 cells. S4. represses proliferation GL261 cells S5. rescues the delayed growth NFIX-null tumor. S6. directly up-regulated gene occupying its promoter</p>
<p>S1. Full images of immunoblotting. S2. NFIX knockdown has no effect on p53 and p21 expression. S3. Knockdown GINS1 by shRNAs in U87 cells. S4. represses proliferation GL261 cells S5. rescues the delayed growth NFIX-null tumor. S6. directly up-regulated gene occupying its promoter</p>
<div>Abstract<p>Our previous study illustrated that nuclear factor IX (NFIX) promotes glioblastoma (GBM) progression by inducing migration and proliferation of GBM cells. However, the underlying mechanism how NFIX regulates cell remains obscure. In this study, we uncovered Go-Ichi-Ni-San 1 (GINS1) is upregulated positively correlated with in human specimen. silencing downregulates expression GINS1, which pivotal for cell-cycle Replenishment GINS1 largely rescues NFIX-null effect...
<div>Abstract<p>Our previous study illustrated that nuclear factor IX (NFIX) promotes glioblastoma (GBM) progression by inducing migration and proliferation of GBM cells. However, the underlying mechanism how NFIX regulates cell remains obscure. In this study, we uncovered Go-Ichi-Ni-San 1 (GINS1) is upregulated positively correlated with in human specimen. silencing downregulates expression GINS1, which pivotal for cell-cycle Replenishment GINS1 largely rescues NFIX-null effect...
Objective: To investigate the inhibitory effect of polyethylene glycol modified magnetic 5-fluorouracil albumin microspheres (PEG-5-FU-MAMS) combined with external constant fields on LoVo colon cancer cells in vitro and mechanism. Methods: The PEG-5-FU-MAMS were prepared by emulsification/solidification method. cultured divided into four groups. Group A was fields; group B pure without C free 5- fluorouracil (5-FU); D magnet. growth observed under an inverted microscopy rate (IR) assayed...