A5062036861- Infrared Target Detection Methodologies
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- HIV/AIDS drug development and treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Remote-Sensing Image Classification
- Advanced Measurement and Detection Methods
- Neural Networks and Applications
- Optical Systems and Laser Technology
- CAR-T cell therapy research
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Neural Networks Stability and Synchronization
- Hepatitis C virus research
- Remote Sensing and Land Use
- Traditional Chinese Medicine Analysis
- CRISPR and Genetic Engineering
- Neonatal Health and Biochemistry
- Pharmaceutical studies and practices
- HIV Research and Treatment
- Computational Drug Discovery Methods
- Traditional Chinese Medicine Studies
- Neuropeptides and Animal Physiology
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
Takeda (United States)
2017-2024
Quantitative BioSciences
2024
Zero to Three
2024
AstraZeneca (United States)
2021
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2021
Yiwu Science and Technology Research Institute
2020
Universität Hamburg
2019
University Medical Center Hamburg-Eppendorf
2019
Xi'an Jiaotong University
2014-2018
Eli Lilly (United States)
2018
Maribavir was approved by the US Food and Drug Administration for treatment of patients aged ≥12 years weighing ≥35 kg with posttransplant cytomegalovirus infection/disease refractory (with/without resistance) to valganciclovir, ganciclovir, cidofovir, or foscarnet, an oral dose 400 mg twice daily. With no pediatric clinical data available difficulty in trial recruitment, population pharmacokinetic modeling simulations were conducted predict pharmacokinetics inform maribavir dosing adolescents.
Objectives: To (1) improve a previously developed PBPK model [1] for maribavir (TAK-620) by including all known metabolic and disposition pathways, CYP3A4-, CYP1A2-, UDP-glucuronosyltransferase (UGT)-mediated metabolism, renal clearance, uptake via organic cation transporter 1 (OCT1); (2) use the validated to assess drug-drug interaction (DDI) liability of as victim CYP1A2- UGT-mediated metabolism in combination with CYP3A4 inducers.Methods: Model development: A vitro ADME clinical PK data...
Abstract The effect of food composition, tablet crushing, and antacid coadministration on maribavir pharmacokinetics was assessed in 2 Phase 1 studies healthy adults. In the first, a single 400‐mg dose administered under fasting conditions, with low‐fat/low‐calorie or high‐fat/high‐calorie meal. second, 100‐mg as crushed tablet, whole alone an antacid. 90% confidence intervals geometric mean ratios were within 80%‐125% for area concentration‐time curve (AUC), but not maximum plasma...
Abstract Maribavir, an orally available antiviral agent, has been approved in multiple countries for the treatment of patients with refractory post‐transplant cytomegalovirus (CMV) infection and/or disease. Maribavir is primarily metabolized by CYP3A4; coadministration CYP3A4 inducers and inhibitors may significantly alter maribavir exposure, thereby affecting its efficacy safety. The effect on exposure was evaluated based a drug‐drug interaction (DDI) study physiologically‐based...
Introduction: Maribavir, a potent and orally bioavailable antiviral, is being evaluated in Phase 3 trials for the treatment of CMV infections transplant patients received FDA Breakthrough Therapy designation.A thorough understanding clinical pharmacology maribavir necessary to guide appropriate use drug who often have multiple comorbidities require complex concurrent medication regimens.Objectives: To summarize data maribavir.Methods: Pharmacokinetic pharmacodynamic assessments were...
Introduction Maribavir, a potent and orally bioavailable antiviral, is being evaluated in Phase 3 trials for the treatment of cytomegalovirus (CMV) infections transplant patients. Often numerous concomitant medications are administered to these patients manage their comorbidities. A thorough evaluation maribavir potential drug–drug interactions (DDIs) warranted required regulatory approval. Objectives To thoroughly evaluate DDIs maribavir. Methods Extensive vitro studies were conducted...
This study was designed to increase the throughput of rat brain microdialysis studies by administration compounds as a cassette opposed discrete study. Eight (carbamazepine, citalopram, desmethylclozapine, diphenhydramine, gabapentin, metoclopramide, naltrexone, and stavudine) were selected administered an intravenous bolus dose at 0.5–3.3 mg/kg each followed infusion 1 per hour for 6 hours in rats or dosing. The dialysate, plasma, brain, cerebrospinal fluid collected analyzed using liquid...
Maribavir is in phase 3 clinical development for treatment of cytomegalovirus infection/disease transplant recipients. Previous research conducted using only intact cynomolgus monkeys indicated biliary secretion as the primary elimination pathway maribavir and that undergoes enterohepatic recirculation (EHR). To clarify exact mechanisms maribavir's EHR behavior, we studied its clearance pathways intravenously administered 14C-labeled bile duct-cannulated (BDC) constructed a...
Ovarian cancer is one of the three most malignant tumors female reproductive system. At present, researchers do not know its pathogenesis, which makes treatment effect unsatisfactory. Metabolomics closely related to drug efficacy, safety evaluation, mechanism action, and rational use. Therefore, identifying ovarian cancer-related metabolites could greatly help understand pathogenesis develop plans. However, measurement inaccurate affects environment, biological experiment time-consuming...
The prodrug strategy has been frequently employed as a chemical approach for overcoming the disadvantages of existing parent drugs. In this report, we synthesized four monoester prodrugs ganciclovir, an anticytomegalovirus drug, and demonstrated their potential advantages in protease-targeted activation biopharmaceutical profiles over compound. We that these i.e., N-benzyloxycarbonyl-(L)-alanine-ganciclovir (CbzAlaGCV), N-benzyloxycarbonyl-(α,l)-aminobutyric acid-ganciclovir (CbzAbuGCV),...
Airborne Forward looking infra-red (FLIR) searcher simulation system can provide multi-mode simulated test environment that almost actual field environment, and simulate integrated performance external interface of airborne FLIR system. Furthermore, the support algorithm optimization image processing, evaluation electro-optical system, also line software evaluate avionics The detailed design structure information cross-linking relationship each component are given in this paper. is composed...
Purpose: To determine occurrence and determinants of resistant hypertension (RHT) among patients attending cardiology clinic the affiliated hospital Hangzhou Normal University, China.Methods: An observational prospective cross-sectional study was conducted with over a period 6 months. After identification RHT, various independent co-variants were tested by logistic regression in order to evaluate RHT.Results: Out 556 patients, 104 (18.7 %) had RHT while 67 (12.1 uncontrolled blood pressure...
With the high efficiency, reusability, and low system risk of infrared scene simulation technology being widely applied in practical applications, researchers have put forward higher requirements for authenticity their results. Therefore, how to reasonably effectively evaluate results scenes has become a key issue further development technology. However, there is currently no unified standard evaluation China, coupled with complexity diversity problems, as well lack effective verification...