A5070755085- Liver Disease Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Healthcare professionals’ stress and burnout
- Birth, Development, and Health
- Patient Satisfaction in Healthcare
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Alcohol Consumption and Health Effects
- Air Quality and Health Impacts
- Job Satisfaction and Organizational Behavior
- Cancer Immunotherapy and Biomarkers
- Sleep and related disorders
- Healthcare Systems and Reforms
- Health disparities and outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Gestational Diabetes Research and Management
- Menopause: Health Impacts and Treatments
- Land Use and Ecosystem Services
- COVID-19 and Mental Health
- Cancer-related molecular mechanisms research
- Global Maternal and Child Health
- Mental Health Treatment and Access
- Blood Pressure and Hypertension Studies
- Ginseng Biological Effects and Applications
- Healthcare Policy and Management
- Obesity, Physical Activity, Diet
State Key Laboratory of Respiratory Disease
2017-2025
Guangzhou Medical University
2017-2025
First Affiliated Hospital of Guangzhou Medical University
2018-2025
Huazhong University of Science and Technology
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Nanjing Medical University
2020-2024
North Sichuan Medical University
2024
Jiangsu Province Hospital
2023-2024
Bohai University
2024
Southeast University
2024
China has seen rapid socio-economic and epidemiolo-gical changes over the past several decades. Economicgrowth plus shifts in environment, lifestyles diethave increased life expectancy, but they have also ledto a higher burden of chronic, non-communicablediseases. Stroke, coronary heart disease (CHD), cancerand diabetes account for 80% deaths 70%of disability-adjusted life-years lost China.
Accumulation of myofibroblasts is critical to fibrogenesis in idiopathic pulmonary fibrosis (IPF). Senescence and insufficient mitophagy fibroblasts contribute their differentiation into myofibroblasts, thereby promoting the development lung fibrosis. Bone morphogenetic protein 4 (BMP4), a multifunctional growth factor, essential for early stage development; however, role BMP4 modulating remains unknown.The aim this study was evaluate using BMP4-haplodeleted mice, BMP4-overexpressed primary...
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance intra-tumoral bacteria, such us E.coli, residing and resulting Colorectal cancer liver metastasis (CRLM). E.coli enhanced lactate production, which mediated M2 macrophage polarization by suppressing nuclear factor-κB -gene binding (NF-κB) signaling through retinoic acid-inducible gene 1 (RIG-I) lactylation. Lactylation RIG-I suppressed recruitment NF-κB to the Nlrp3 promoter...
The presence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and the permanent integration HBV into host genome confers risk viral reactivation hepatocellular carcinoma. Nucleoside/nucleotide analogues alone have little or no capacity to eliminate replicative templates consisting cccDNA integrated DNA. Recently, CRISPR/Cas9 technology has been widely applied as a promising genome-editing tool, HBV-specific CRISPR-Cas9 systems were shown effectively mediate disruption....
The cellular and molecular mechanisms by which indole-3-acetic acid (IAA), a tryptophan-derived metabolite from gut microbiota, attenuates inflammation oxidative stress has not been fully elucidated. present study was to unearth the protective effect underlying mechanism of IAA against lipopolysaccharide (LPS)-induced inflammatory response free radical generation in RAW264.7 macrophages. significantly ameliorated LPS-induced expression interleukin-1β (IL-1β), interleukin-6 (IL-6), monocyte...
Social change, intensified by industrialization and globalization, has not only changed people's work lives but also their personal lives, especially in developing countries. The aim of this study was to provide evidence recommendations regarding family structure, function, mental health actively respond rapid social change. A cross-sectional survey conducted face-to-face door-to-door from July 2011 September 2012 Hubei Province, central China. Family structure comprised alone, couple,...
<h3>Objective</h3> Tumour biomarkers are used as indicators for cancer screening and predictors therapeutic responses prognoses in patients. We aimed to identify genetic loci that influence concentrations of antigen 19-9 (CA19-9), carcinoembryonic (CEA) α fetoprotein (AFP), investigated the associations between significant single nucleotide polymorphisms (SNPs) with risks oesophageal squamous cell (OSCC), pancreatic hepatocellular cancers. <h3>Design</h3> carried out a genome wide...
Plasma lipid levels are important risk factors for cardiovascular disease and influenced by genetic environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci been primarily in European populations. In order to identify markers a Chinese population analyze the heterogeneity between Europeans Asians, especially Chinese, we performed meta-analysis of two on four common traits including total cholesterol (TC), triglycerides...
Evidence from epidemiological studies suggested that shorter and longer duration of nocturnal sleeping may increase the risk hypertension for older adults. Little is known about midday nap on variability blood pressure among In this study, we examined whether habitual associated with level or in a middle-aged Chinese population.A total 27 009 participants (mean age 63.6 years) Dongfeng-Tongji Cohort Study received baseline examination including physical laboratory tests,...
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic lung characterized by abnormal inflammation, persistent and progressive function decline. The anti-inflammatory actions of tanshinone IIA, which the most important active component from Chinese herbal medicine Danshen, have been well studied. However, it remains unknown whether sodium IIA sulfonate (STS) protects against development COPD. Here we found that STS inhalation (5 mg/kg, 30 min per session, twice day) significantly...
The aim of this study is to examine the bidirectional association between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM).The data was derived from Dongfeng-Tongji cohort study, which established in 2008 followed until October 2013. NAFLD classified as none, mild, moderate/severe based on ultrasound examination. analysis incident T2DM risk included 18,111 participants free at baseline duration follow-up 4.60 ± 0.60 years. Cox proportional regression model used...
A fundamental element of acute lung injury (ALI) is the inflammatory response, which can affect entire respiratory system, including tract and alveoli. Berberine has gained attention because its anti‐inflammatory effects. Nuclear factor‐erythroid 2‐related factor 2 (Nrf2) endoplasmic reticulum (ER) stress are involved in injury. Nrf2 also acts as a protein kinase‐like ER kinase (PERK) substrate heart disease. Therefore, this study investigated effect berberine against lipopolysaccharide...
Emerging studies have investigated the association between different anthropometric indices with diabetes risk but results were inconsistent. The aims of study to examine associations incident and whether novel improve prediction beyond traditional among elderly Chinese. Nine thousand nine hundred sixty-two individuals (age ≥ 60 years old) derived from prospective Dongfeng-Tongji cohort included. Hazard ratio (HR) corresponding 95% confidence interval (CI) evaluated by Cox proportional...
ABSTRACT Background Public health workers at the Chinese Centre for Disease Control and Prevention (China CDC) primary care institutes (PHIs) were among main who implemented prevention, control, containment measures. However, their efforts status have not been well documented. We aimed to investigate working conditions of front line public in China during COVID-19 epidemic. Methods Between 18 February 1 March 2020, we conducted an online cross-sectional survey 2,313 CDC 4,004 PHI five...
Abstract Background Poor mental health status and associated risk factors of public workers have been overlooked during the COVID-19 pandemic. This study used effort–reward imbalance model to investigate association between work-stress characteristics (effort, over-commitment, reward) problems (anxiety depression) among front-line pandemic in China. Methods A total 4850 valid online questionnaires were collected through a self- constructed sociodemographic questionnaire, adapted ERI 9-item...
In 2009, China launched its new round of health care reform. One priorities was to strengthen primary and establish a family practice system. This study examined the relationship between use physician for quality care. Eight organizations were sampled from three cities in Guangdong Province, China. thousand six hundred forty five patients age 18 older who visited one sites as their usual source systematically selected surveyed using Johns Hopkins China-validated Primary Care Assessment Tool...
Famine exposure in early life has been reported to be associated with higher risk of hypertension prevalence adults. The aim the present study was investigate association Chinese famine during adults.There were 8742 participants born between 1952 and 1964 derived from Dongfeng-Tongji cohort included study. Participants classified as nonexposed group, fetal exposed early-childhood mid-childhood late-childhood respectively. Logistic regression model used explore adults.The among individuals...
Abstract The study aimed to assess the association between total, direct and indirect bilirubin nonalcoholic fatty live disease (NAFLD) risk given its high prevalence serious clinical prognosis. Among 27,009 subjects who participated in a healthy screening program from Dongfeng-Tongji cohort 2008, 8189 eligible (aged 35–86 years; males, 43.95%) were ultimately enrolled. incidence rates of NAFLD 2013 compared with respect baseline levels among free effect sizes estimated by logistic...