A5100745182- Viral Infections and Immunology Research
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Signaling Pathways in Disease
- CAR-T cell therapy research
- Diet, Metabolism, and Disease
- Neuroendocrine Tumor Research Advances
- Cardiomyopathy and Myosin Studies
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Neuroblastoma Research and Treatments
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Immunodeficiency and Autoimmune Disorders
- Cardiac Imaging and Diagnostics
- Systemic Lupus Erythematosus Research
- Mobile Agent-Based Network Management
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Workplace Violence and Bullying
- Inflammasome and immune disorders
Second Xiangya Hospital of Central South University
2024-2025
Central South University
2024-2025
Huazhong University of Science and Technology
2015-2024
Union Hospital
2014-2024
Anhui Medical University
2024
Tongji Hospital
2024
Union Hospital
2011-2024
Trend Micro (Japan)
2024
Wuhan University of Science and Technology
2023
Wuhan University
2023
Evidence supports using antiplatelet therapy in patients with acute ischemic stroke. However, neurological deterioration remains common under the currently recommended regimen, leading to poor clinical outcomes.
Myocarditis is an inflammatory cardiovascular disease which contributes to dilated cardiomyopathy (DCM) and heart failure. Canagliflozin (CANA) exerts anti-inflammatory cardioprotective effects in failure besides its hypoglycemic effect. However, the role of CANA myocarditis has not been elucidated. In this work, treatment markedly alleviated cardiac inflammation improved function experimental autoimmune (EAM) mice induced by α-myosin-heavy chain peptides. The expressions NLRP3 inflammasome...
Abstract Acute viral myocarditis (AVMC) is characterized by virus-triggered myocardial inflammation, and Coxsackievirus B3 (CVB3) the primary pathogen. We previously proved that Th17 cells, besides having proinflammatory effects, were involved in AVMC enhancing humoral response. However, relationship between cells CVB3 replication remains unknown. In this experiment, we infected BALB/c mice with for establishing models then found that, increase of replication, expressions splenic serum...
In this study, we investigated the hypothesis that regulatory T cells (T(reg)) are involved in immunomodulatory effects of statins on rheumatoid arthritis (RA) patients. The 12-week study cohort consisted 55 RA patients and 42 control subjects allocated to either a group treated with atorvastatin (AT) (20 mg/day) or non-AT group. T(reg) numbers, suppressive function, serum inflammatory markers, disease activity were evaluated before after therapy. Furthermore, AT frequency function...
Abstract Impaired hearing and cognition are disabling conditions among older adults. Research has presented inconsistent conclusions regarding impairment posing a risk for cognitive impairment. We aimed to assess this from published evidence via searching PubMed Embase, the inception of databases indexed December 2, 2016. For those high-quality studies retrieved, relative (RR) 95% confidence intervals (CIs) were combined estimate Eleven cohort included in present study. Pooled results found...
The aim of this study is to examine the bidirectional association between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM).The data was derived from Dongfeng-Tongji cohort study, which established in 2008 followed until October 2013. NAFLD classified as none, mild, moderate/severe based on ultrasound examination. analysis incident T2DM risk included 18,111 participants free at baseline duration follow-up 4.60 ± 0.60 years. Cox proportional regression model used...
Aims: Increasing evidences confirm the role of immune activation in pathogenesis chronic heart failure (CHF). Regulatory T cells appear central to control homeostasis. We assessed hypothesis that circulating frequency and function CD4+CD25+ Foxp3+CD127low regulatory (Tregs) would be deranged patients with CHF. Methods: Ninety-nine CHF due non-ischemic (NIHF) or ischemic etiology (IHF) 24 donors were enrolled study. Frequency Tregs was evaluated by flow cytometry. Foxp3 peripheral blood...
Abstract We developed a transgenic (Tg) mouse that expresses TGF-β under control of the IL-2 promoter to investigate Th3 cell differentiation both in vitro and vivo. previously found repetitive Ag stimulation results constant expression Foxp3 TGF-β-Tg cells acquire regulatory function independent surface CD25. To examine vivo compare them with thymic-derived CD4+CD25+ T (Treg), we introduced transgene into IL-2-deficient (IL-2−/−) mice. induction, differentiation, TGF-β-derived Foxp3+ were...
Abstract The study aimed to assess the association between total, direct and indirect bilirubin nonalcoholic fatty live disease (NAFLD) risk given its high prevalence serious clinical prognosis. Among 27,009 subjects who participated in a healthy screening program from Dongfeng-Tongji cohort 2008, 8189 eligible (aged 35–86 years; males, 43.95%) were ultimately enrolled. incidence rates of NAFLD 2013 compared with respect baseline levels among free effect sizes estimated by logistic...
Background Platelet aggregation mediated by inflammation played a critical role in the development of coronary heart diseases (CHD). Our previous clinical researches showed that Th17 cells and their characteristic cytokine IL-17A were associated with plaque destabilization patients acute syndrome (ACS). However, potent effect on platelets-induced atherothrombosis remains unknown. Methods Results In this study, we detected plasma levels platelet stable angina (SA), unstable (UA), myocardial...
Workplace violence (WPV) is a major issue for nurses worldwide, causing both physical and mental harm, impairing their ability to work effectively. Several researches reported on the prevalence of WPV among in China, ranging from 56.4 71%. However, little information available about correlates different types across departments tertiary hospitals China. A self-designed WeChat-based questionnaire was utilized, incorporating demographic occupational factors. measured using Chinese version...
Whether cigarette smoking and moderate drinking are associated with non-alcoholic fatty liver disease (NAFLD)has not been fully described. This study investigated the separate joint effects of on Chinese men NAFLD.Across-sectional assay from DFTJ Cohort was performed a size 9432 elderly excluding excessive alcohol consumption (<210g/week). Fatty diagnosed by standardized ultrasonographic inspection. The odds ratio (OR) for prevalence NAFLD were analyzed using multiple logistic regression...