A5101962202- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Catalysts for Methane Reforming
- Cancer Immunotherapy and Biomarkers
- Advancements in Solid Oxide Fuel Cells
- Catalysis and Hydrodesulfurization Studies
- Electrocatalysts for Energy Conversion
- Immune cells in cancer
- Zeolite Catalysis and Synthesis
- Mesenchymal stem cell research
- Sphingolipid Metabolism and Signaling
- Cytokine Signaling Pathways and Interactions
- Mesoporous Materials and Catalysis
- Gas Sensing Nanomaterials and Sensors
- Oxidative Organic Chemistry Reactions
- Advanced Glycation End Products research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Ammonia Synthesis and Nitrogen Reduction
- Protein Hydrolysis and Bioactive Peptides
- Nanomaterials for catalytic reactions
- CAR-T cell therapy research
- Electronic and Structural Properties of Oxides
- Magnetic and transport properties of perovskites and related materials
Central South University
2017-2024
Hokkaido University
2022-2024
Second Xiangya Hospital of Central South University
2017-2024
Army Medical University
2024
China Pharmaceutical University
2024
Renmin University of China
2016-2024
Trend Micro (Japan)
2024
Southern Medical University
2023
Nanfang Hospital
2023
University of Chinese Academy of Sciences
2006-2022
Mesenchymal stem cells (MSCs) have been employed successfully to treat various immune disorders in animal models and clinical settings. Our previous studies shown that MSCs can become highly immunosuppressive upon stimulation by inflammatory cytokines, an effect exerted through the concerted action of chemokines nitric oxide (NO). Here, we show also enhance responses. This immune-promoting occurred when proinflammatory cytokines were inadequate elicit sufficient NO production. When inducible...
Mammalian mesenchymal stem cells (MSCs) have been shown to be strongly immunosuppressive in both animal disease models and human clinical trials. We reported that the key molecule mediating immunosuppression by MSCs is species dependent: indoleamine 2,3-dioxygenase (IDO) inducible nitric oxide synthase (iNOS) mouse. In present study, we isolated from several mammalian species, each of a different genus, investigated involvement IDO iNOS during MSC-mediated immunosuppression. The...
An imbalance between normal adipogenesis and osteogenesis by mesenchymal stem cells (MSCs) has been shown to be related various human metabolic diseases, such as obesity osteoporosis; however, the underlying mechanisms remain elusive. We found that interaction osteopontin (OPN), an arginine-glycine-aspartate-containing glycoprotein, integrin αv/β1 plays a critical role in lineage determination of MSCs. Although OPN is well-established marker during osteogenesis, its MSC differentiation still...
Evidence supports using antiplatelet therapy in patients with acute ischemic stroke. However, neurological deterioration remains common under the currently recommended regimen, leading to poor clinical outcomes.
A three-electrode system composed of TiO2/Ni as the working electrode, porous nickel counter and saturated calomel electrode (SCE) reference was used for photoelectrocatalytic degradation organic compounds. The sulfosalicylic acid (SSal) under anodic bias potential investigated. It is shown that SSal can be degraded effectively external increased up to 700 mV (vs SCE). characteristics by electrochemical impedance spectroscopy (EIS) also from EIS appears a simple reaction on surface,...
Recently, emerging evidence has demonstrated that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNAs (lncRNAs), contributes to the initiation and development of tumors, including osteosarcoma (OS). Multiple studies have suggested an oncogenic role MALAT1 high-mobility group protein B1 (HMGB1) in OS tumorigenesis metastasis, but effects mechanisms are not unanimous. Here, we showed HMGB1 were significantly increased human cell lines knockdown reduced...
Mesenchymal stem cells (MSCs) are believed to exert their regenerative effects through differentiation and modulation of inflammatory responses. However, the relationship between severity inflammation cell-mediated tissue repair has not been formally investigated. In this study, we applied different concentrations dexamethasone (Dex) anti-CD3-activated splenocyte cultured with or without MSCs. As expected, Dex exhibited a classical dose-dependent inhibition T-cell proliferation....
One of the obstacles for cancer immunotherapy is inefficiency CD8(+) T-cell recruitment to tumors. STAT3 has been shown suppress antitumor functions in various models, part by restricting accumulation T cells. However, underlying molecular mechanism which cells inhibits their tumors remains be defined. Here, we show that signaling chemokine CXCL10 production tumor-associated myeloid reducing IFNγ expression We further demonstrate ablating allows CXCR3, receptor CXCL10, on cells, resulting...
The poor efficacy of the in vivo anti-tumor immune response has been partially attributed to ineffective T-cell responses mounted against tumor. Fas-FasL-dependent activation-induced cell death (AICD) T cells is believed be a major contributor compromised immunity. molecular mechanisms AICD are well-investigated, yet possibility regulating for cancer therapy remains explored. In this study, we show that histone deacetylase inhibitors (HDACIs) can inhibit apoptosis CD4+ within tumor, thereby...