A5100349870- Rheumatoid Arthritis Research and Therapies
- Glaucoma and retinal disorders
- Musculoskeletal synovial abnormalities and treatments
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Retinal Diseases and Treatments
- Spondyloarthritis Studies and Treatments
- Osteoarthritis Treatment and Mechanisms
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cancer-related gene regulation
- Orthopedic Infections and Treatments
- Corneal surgery and disorders
- Immune Response and Inflammation
- Shoulder Injury and Treatment
- Knee injuries and reconstruction techniques
- Salivary Gland Disorders and Functions
- Liver Diseases and Immunity
- Viral Infections and Immunology Research
- T-cell and B-cell Immunology
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- interferon and immune responses
- Psoriasis: Treatment and Pathogenesis
- MicroRNA in disease regulation
Peking University
2023-2025
Peking University Third Hospital
2023-2025
Xiangya Hospital Central South University
2012-2024
Central South University
2015-2024
Northern Jiangsu People's Hospital
2024
Zhejiang Chinese Medical University
2023-2024
Zigong First People's Hospital
2024
Jiaxing University
2023
Fuwai Yunnan Cardiovascular Hospital
2022-2023
Kunming Medical University
2022-2023
Objective More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts this, and we undertook study to test our hypothesis trisomy (47,XXX; occurring in ∼1 1,000 live births) would be increased patients with female‐predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], biliary cirrhosis, rheumatoid arthritis [RA]) compared without...
Recently, emerging evidence has demonstrated that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNAs (lncRNAs), contributes to the initiation and development of tumors, including osteosarcoma (OS). Multiple studies have suggested an oncogenic role MALAT1 high-mobility group protein B1 (HMGB1) in OS tumorigenesis metastasis, but effects mechanisms are not unanimous. Here, we showed HMGB1 were significantly increased human cell lines knockdown reduced...
MIR34A (microRNA 34a) is a tumor suppressor gene, but how it regulates chemotherapy response and resistance not completely understood. Here, we show that the microRNA MIR34A-dependent high mobility group box 1 (HMGB1) downregulation inhibits autophagy enhances chemotherapy-induced apoptosis in retinoblastoma cell. HMGB1 multifaceted protein with key role autophagy, self-degradative, homeostatic process context-specific cancer. expression through direct MIR34A-binding site within 3′...
Objective Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy. We develop strategies for overcoming IFNG-mediated adaptive pancreatic ductal adenocarcinoma (PDAC). Design screened 429 kinase inhibitors blocking IFNG-induced checkpoint (indoleamine 2,3-dioxygenase 1 (IDO1) and CD274) expression human PDAC cell line. evaluated ability of cyclin-dependent (CDK) inhibitor dinaciclib to block IDO1 CD274 24 mouse...
Background & AimsPancreatitis is characterized by acinar cell death and persistent inflammation. Ferroptosis a type of lipid peroxidation-dependent necrosis, which negatively regulated glutathione peroxidase 4. We studied how trypsin, serine protease secreted pancreatic cells, affects the contribution ferroptosis to triggering pancreatitis.MethodsIn vitro, mouse line 266-6 primary cells were used investigate effect exogenous trypsin on sensitivity. Short hairpin RNAs designed silence gene...
Background The spinal column is a frequent site for metastases, affecting over 30% of solid tumor patients. Identifying the primary essential guiding clinical decisions but often requires resource‐intensive diagnostics. Purpose To develop and validate artificial intelligence (AI) models using noncontrast MRI to identify sites aiming enhance diagnostic efficiency. Study Type Retrospective. Population A total 514 patients with pathologically confirmed metastases (mean age, 59.3 ± 11.2 years;...
Background: Assessing the magnitude of total cancer burden due to smoking and secondhand smoke is imperative for formulation impactful prevention mitigation strategies. Utilizing findings from 2021 Global Burden Diseases, Injuries, Risk Factors Study (GBD), this analysis informs evidence-based planning control tobacco regulation initiatives at national international levels.Methods: As part GBD, we analyzed two pairs risk-outcome combinations estimate smoking- second-hand smoke-attributable...
Background: The shape and size of the meniscus are closely related to stability knee joint anterior cruciate ligament (ACL) injury. Studies have confirmed correlation between meniscal morphology isolated ACL Purpose: To investigate parameters, including morphological changes, in participants with Study Design: Cross-sectional study; Level evidence, 3. Methods: This retrospective study, conducted from January December 2021, compared 70 patients injury intact ACL. slopes posterior angles were...
Objective Sjögren's syndrome ( SS ) and systemic lupus erythematosus SLE are related by clinical serologic manifestations as well genetic risks. Both diseases more commonly found in women than men, at a ratio of ~10 to 1. Common X chromosome aneuploidies, 47, XXY XXX , enriched among men women, respectively, either disease, suggesting dose effect on the chromosome. Methods We examined cohorts patients constructing intensity plots single‐nucleotide polymorphism alleles, along with determining...
Reprogramming lipid metabolism is considered a fundamental step in tumourigenesis that influences ferroptosis. However, molecular mechanisms between and ferroptosis remain largely unknown. Results from the drug screening of 464 inhibitors (for 164 targets) applied to cells indicated 4 targeted bromodomain-containing protein (BRD4) significantly inhibiting erastin-induced Functional studies proved loss BRD4 weakened oxidative catabolism mitochondria, protecting excessive accumulation...
This study was undertaken to explore the value of interleukin-1 receptor 2 (IL1R2) as a novel potential biomarker for diagnosis sepsis and discrimination gram-negative (G)/gram-positive (G) bacterial sepsis. The performed in Kunming mice septic patients. Inactive Escherichia coli or Staphylococcus aureus were used stimulate (10 CFU/kg). In clinical study, patients with different pathogen infection studied, healthy volunteers systemic inflammatory response syndrome without definite enrolled...
Abstract Noncoding RNAs (ncRNAs), including long ncRNAs (lncRNA) have manifested an important role in the pathophysiology of many diseases. Glaucoma is a primary cause irreversible blindness worldwide. However, involvement lncRNAs glaucoma remains largely unknown. Here, we performed lncRNA expression assay based on clinical tissues and identified specific functional lncRNA, NR_003923, investigated its potential glaucoma. Knockdown NR_003923 human Tenon’s capsule fibroblast cells (HTFs)...
To assess the effect of filgotinib, which preferentially inhibits Janus kinase 1 (JAK1), on MRI measures structural change in SI joint patients with active AS TORTUGA trial.Adults and inadequate response/intolerance to two or more NSAIDs were randomized 1:1 filgotinib 200 mg (n = 58) placebo once daily for 12 weeks. In this post hoc analysis, T1-weighted scans evaluated by independent readers using Spondyloarthritis Research Consortium Canada (SPARCC) Sacroiliac Joint Structural Score (SSS)...
Abstract Objectives Diagnostic imaging plays an important role in the pre-treatment workup of knee osteoarthritis (OA) and rheumatoid arthritis (RA). Herein, we identified a useful MRI sign infrapatellar fat pad (IPFP) to improve diagnosis. Methods Eighty-one age- sex-matched RA OA patients each, with pathological diagnosis were retrospectively evaluated. All randomized MR images blinded independently reviewed by two radiologists. The assessment process included initial diagnosis,...
Osteosarcoma is the most common primary malignant bone tumor, and frequent acquisition of chemoresistance often an obstacle to achieving favorable outcomes during chemotherapy. Recently, Krüppel-like factor 4 (KLF4) has been shown be associated with chemotherapy resistance in a few tumors; however, involvement KLF4 osteosarcoma cells remains unknown. In this study, quantitative real-time PCR western blot analysis revealed that expression was significantly increased response cisplatin,...
Purpose: To evaluate the potential antifibrotic effect of rosiglitazone (RSG), a peroxisome proliferator-activated receptor γ (PPARγ)-selective agonist, on subconjunctival fibrosis in rabbit model glaucoma filtration surgery (GFS) vivo, and to investigate underlying mechanisms human Tenon's fibroblasts (HTFs) vitro. Methods: GFS were performed adult male New Zealand white rabbits with chronic ocular hypertension previously established by injections 2% methylcellulose into anterior chamber....
Abstract Objectives To assess the effects of filgotinib on inflammatory and structural changes at various spinal locations, based MRI measures in patients with active AS TORTUGA trial. Methods In trial, received 200 mg (n = 58) or placebo once daily for 12 weeks. this post hoc analysis, spine MRIs were evaluated using Canada–Denmark (CANDEN) scoring system to from baseline week total subscores inflammation, fat, erosion new bone formation (NBF) anatomical locations. Correlations assessed...
Although hand synovitis is prevalent in the older population, etiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of synovitis, but little known about their relationship. We assessed association between hyperuricemia and large population-based sample.