A5101847409- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Antioxidant Activity and Oxidative Stress
- Retinopathy of Prematurity Studies
- Retinoids in leukemia and cellular processes
- Multiple Myeloma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Corneal Surgery and Treatments
- Virus-based gene therapy research
- Thermal Regulation in Medicine
- Genetic Associations and Epidemiology
- Mining and Gasification Technologies
- Vitamin D Research Studies
- SARS-CoV-2 and COVID-19 Research
- Protein Kinase Regulation and GTPase Signaling
- Thermochemical Biomass Conversion Processes
- Proteoglycans and glycosaminoglycans research
- Plant Parasitism and Resistance
- Cancer, Hypoxia, and Metabolism
- Protein purification and stability
- Retinal Development and Disorders
- Chemokine receptors and signaling
Fudan University
2025
University of Electronic Science and Technology of China
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2012-2023
Nanjing University
2023
Nanjing General Hospital of Nanjing Military Command
2023
Southwest Jiaotong University
2014-2016
Nanjing Forestry University
2007-2016
Peking University
2009
An ongoing outbreak of severe respiratory pneumonia associated with the 2019 novel coronavirus has recently emerged in China. Here we report epidemiological, clinical, laboratory and radiological characteristics 19 suspect cases. We compared positive ratio 2019-nCoV nucleic acid amplification test results from different samples including oropharyngeal swab, blood, urine stool 3 fluorescent RT-PCR kits. Nine out patients had infection detected using swab samples, virus was also eight these...
BackgroundMyopia is a good model for understanding the interaction between genetics and environmental stimuli. Here we dissect biological processes affecting myopia progression.MethodsHuman Genetic Analyses: (1) gene set analysis (GSA) of new genome wide association study (GWAS) data 593 individuals with high (refraction ≤ -6 diopters [D]); (2) over-representation (ORA) 196 genes de novo mutations, identified by whole sequencing 45 high-myopia trio families, (3) ORA 284 previously reported...
Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as novel susceptibility gene axial length (rs10453441, Pmeta=3.9 × 10−13) corneal curvature (Pmeta=2.9 10−40) confirm the previously reported between GJD2 myopia. significantly associates extreme myopia case–control...
Purpose Human longevity results from a number of factors, including genetic background, favorable environmental, social factors and chance. In this study, we aimed to elucidate the association human with variations in several major candidate genes Han Chinese population. Methods A case-control study 1015 long-lived individuals (aged 90 years or older) 1725 younger controls (30–70 old) was undertaken. Rs2075650 TOMM40 firstly genotyped using ABI SNaPshot method an initial cohort consisted 597...
The CYP1B1 gene has been shown to be related primary open-angle glaucoma (POAG). This study aimed identify the mutation profile of in Chinese individuals with POAG.The included 416 unrelated cases diagnosed as POAG by standard ophthalmological examinations, and 657 healthy controls a population. Genomic DNA was collected from peripheral blood all participants. coding sequence amplified PCR genomic DNA, followed direct sequencing.Among patients POAG, 13 missense mutations, including nine...
Purpose: Recently, three large genome-wide association studies have identified multiple variants associated with primary open angle glaucoma (POAG) near the ABCA1 gene. Considering that POAG and closure (PACG) share many similar clinical manifestations, present study was conducted to investigate whether these genetic were also PACG in a Han Chinese population. Methods: A case-control of 1122 cases (PACG/PAC) 1311 normal, matched controls undertaken. Seven single-nucleotide polymorphisms...
The complete mitochondrial genome of Medicago truncatula (M. truncatula) was reported in this study. (mitogenome) assembled to 271 618 nt. mitogenome contains 31 protein-coding genes, three rRNA genes and 16 tRNAs. overall base composition the descending order is A: 27.21%, C: 22.61%, G: 22.78% T: 27.40%, G + C content 45.39%. Additionally, 30 exons 17 introns were identified eight nine tandem repeats with period size from 10 nt 33 Phylogenetic analysis shows that M. evolutionarily closest...
High myopia is one of the leading causes blindness worldwide. However, exact etiology high remains unraveled despite numerous attempts elucidation. Previous genome-wide association study (GWAS) has revealed that four single nucleotide polymorphisms (SNPs), including rs2969180, rs1652333, rs9307551, and rs7837791, were associated with in Caucasians. The present was conducted to investigate whether these genetic variants Han Chinese. These SNPs genotyped by SNaPshot method a Chinese cohort...
To investigate the association between high myopia (HM) and single nucleotide polymorphisms (SNPs) in myocilin (MYOC), hepatocyte growth factor (HGF), receptor (MET), aggrecan (ACAN) genes a Han Chinese population.Sixteen SNPs were genotyped by SNaPshot method subject group composed of 1052 HM patients 1070 controls. Statistical analysis was performed to determine susceptibility HM.Two (rs3784757 rs1516794) ACAN significantly associated with (p=0.0334 0.0236, odds ratio [OR]=0.83 0.79,...
Insulin-like growth factor 1 (IGF1) and insulin-like receptor (IGF1R) have been shown to influence the development of form-deprivation myopia. However, genetic association between these two genes high myopia remains inconsistent in different studies. This study was conducted investigate IGF1and IGF1R a Han Chinese population.Fourteen single nucleotide polymorphisms (SNPs) IGF1 were genotyped by SNaPshot method subject group composed 1244 patients 1380 controls. The genotyping data analyzed...
To comprehensively evaluate the potential association of COL1A1 polymorphisms with high myopia by a systematic review and Meta-analysis.All studies on reported up to June 10, 2014 in PubMed, Embase, Web Science, Chinese Biomedical Database were retrieved. Odds ratios (ORs) 95% confidence intervals (95% CIs) analyzed for single-nucleotide (SNPs) using fixed- random- effects models according between-study heterogeneity. Publication bias analyses conducted Egger's test.A total four from papers...
Fibroblast growth factor 10 (FGF10) is implicated in the and development of eye. Four singles nucleotide polymorphisms (SNPs) FGF10 gene (including rs1384449, rs339501, rs12517396 rs10462070) were found to be associated with extreme myopia (EM, refractive error ≤ - 10.0 diopters) Japanese Chinese Taiwan population. This case-control association study was conducted explore relationship between these four SNPs high a western population.A total 869 patients (HM, including 485 EM patients) 899...
Myopia is the most common cause of refractive error worldwide. High myopia a severe type myopia, which usually accompanies pathological changes in fundus. To identify high susceptibility genes, DNA-pooling based genome-wide association analysis was used to search for correlation between single nucleotide polymorphisms and Han Chinese cohort (cases vs. controls discovery stage: 507 294; replication stage 1: 991 1,025; 2: 1,021 52,708). Three variants (rs10889602T/G, rs2193015T/C,...
Many genes have been associated with primary open-angle glaucoma (POAG). This study was conducted to investigate whether catalase (CAT) polymorphisms play a significant role in POAG Chinese population.A cohort of 416 unrelated patients and 997 control subjects included this case-control association study. CAT functional single-nucleotide (SNPs), including rs1001179, rs7943316, rs769217, were genotyped by SNaPshot method. The genotype allele frequencies evaluated using the χ2 tests. linkage...
Lattice corneal dystrophy type I (LCDI) is associated with a large number of missense mutations in the transforming growth factor β induced (TGFBI) gene. The aim present study was to analyze TGFBI mutation Chinese family LCDI, and describe clinical features phenotype-genotype correlation within this family. Three generations LCDI were enrolled current study. Complete ophthalmic examinations performed on all members screenings coding regions analyzed using direct sequencing method. All...
Background: Retinitis pigmentosa (RP) is a complex inherited and progressive degenerative retinal disease. The eyes shut homolog (EYS) frequently associated with RP surprisingly high. Exploring the function of EYS quite difficult due to unique gene size species specificity. Gene therapy may provide breakthrough treat this Therefore, exploring clarifying pathogenic mutations EYS-associated has important guiding significance for clinical treatment. Methods: Clinical molecular genetic data were...