A5065779339- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Ocular Surface and Contact Lens
- Visual perception and processing mechanisms
- Retinal and Optic Conditions
- Photoreceptor and optogenetics research
- Connexins and lens biology
- Intraocular Surgery and Lenses
- Retinopathy of Prematurity Studies
- Neuroscience and Neuropharmacology Research
- Ophthalmology and Visual Health Research
- Patient Satisfaction in Healthcare
- Ocular and Laser Science Research
- Spaceflight effects on biology
- Health disparities and outcomes
- Digital Imaging in Medicine
- Facial Trauma and Fracture Management
- Health Promotion and Cardiovascular Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Acute Ischemic Stroke Management
- Healthcare Systems and Reforms
Hong Kong Polytechnic University
2016-2025
UK Biobank
2021
University of Canberra
2008
Queensland University of Technology
2003
University of Auckland
1992-2000
Faculty of 1000 (United Kingdom)
1994
American Academy of Optometry
1994
Anna Needs Neuroblastoma Answers
1992
University of Bradford
1984-1989
Bradford Royal Infirmary
1987-1989
The SARS-CoV-2 RNA has been detected in tears and conjunctival samples from infected individuals. Conjunctivitis is also reported a small number of cases. We evaluated ocular symptoms tropism group patients with COVID-19. Fifty-six were recruited as subjects. Relevant medical histories obtained the electronic record system. Ocular history data by communicating directly Surface Disease Index (OSDI) Salisbury Eye Evaluation Questionnaire (SEEQ) used to assess anterior surface condition before...
Abstract Purpose: This study aimed to examine the rates of microbial contamination, and identify contaminants associated with contact lenses lens care accessories used by a group young wearers. Methods: Collected lenses, cases, solutions were studied bacterial culture. Contamination these samples recorded compared those reported in previous studies. Results: Of tested, 9% extracts, 34% case extracts 11% solution contaminated ocular pathogenic microorganisms. Serratia spp., Staphylococcus...
Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as novel susceptibility gene axial length (rs10453441, Pmeta=3.9 × 10−13) corneal curvature (Pmeta=2.9 10−40) confirm the previously reported between GJD2 myopia. significantly associates extreme myopia case–control...
A mutation miR-184(+57C>T) in the seed region of miR-184 (encoded by MIR184 [MIM*613146]) results familial severe keratoconus combined with early-onset anterior polar cataract and endothelial dystrophy, iris hypoplasia, congenital cataract, stromal thinning (EDICT) syndrome (MIM#614303). In order to investigate phenotypic spectrum resulting from mutation, was sequenced a cohort mixed ethnicity Chinese axial myopia cohort.Sequencing performed 780 unrelated patients 96 Han southern subjects...
Purpose To compare and contrast the prevalence of myopia other refractive errors in Xiamen city, countryside (Southern China), Singapore. Methods One hundred thirty-two schoolchildren aged 6 to 7 years from 104 countryside, 146 Singapore city were recruited join study. Cycloplegic autorefraction, keratometry, biometry measurements performed on all children. Results The was 12.3% 9.1% 3.9% countryside. astigmatism higher compared with Xiamen. rates hyperopia anisometropia similar three...
<h3>Importance</h3> Uncertainty currently exists about whether the same genetic variants are associated with susceptibility to low myopia (LM) and high (HM) hyperopia. Addressing this question is fundamental understanding genetics of refractive error has clinical relevance for genotype-based prediction children at risk HM identification new therapeutic targets. <h3>Objective</h3> To assess a common set HM, LM, <h3>Design, Setting, Participants</h3> This association study assessed unrelated...
The purpose of this study was to measure the changes in ocular dimensions with accommodation, particular reference radius curvature posterior surface crystalline lens. increase power eye accommodation is considered arise primarily from a decrease anterior lens, role somewhat unclear. We measured axial (A-Scan ultrasonography), corneal (keratometry), refractive error (auto-refractor) and radii lenticular surfaces (video phakometry) for 11 subjects, mean age 21.2 +/- 2.6 years, five levels up...
The measurement of tear break-up time (TBUT) in assessing stability the film is somewhat controversial, even though technique widely used. We examined reliability within and among examiners conclude that measurements TBUT can be made reliably; full-beam observation cornea preferable to scanning with a narrow slit making measurements. There may differences same subjects examiners, but these are smaller more experienced practitioners. In Hong Kong Chinese (HK-Chinese), appears likely first...
Previous studies suggest that myopia in parents may influence the genesis of their offspring. In this study, we surveyed 2888 children Chinese descent China and Hong Kong to determine relationship between refraction state children. The age range was 7–17 years, Refraction measured using a Canon R‐22 objective infrared autorefractor survey on family history ametropia conducted questionnaire. We found with myopic are more likely be myopic.
The aims were to determine the level of compliance contact lens wearers, identify which procedures have highest levels non-compliance and study effectiveness a enhancement strategy on compliance.The for each subject was evaluated with self-administered questionnaire together microbiological examination their lenses, cases care solutions. effect an intervention improve determined by controlled trial. A regular self-review exercise proper handling given test group once every three months 12...
To investigate the association of high myopia with polymorphisms in hepatocyte growth factor (HGF) gene, a potential candidate for development.Single nucleotide (SNPs) were screened and identified HGF gene region denaturing high-performance liquid chromatography, their linkage disequilibrium pattern was established Han Chinese population (n=150). Tag SNPs selected genotyped using restriction digestion fluorescence polarization assays 128 nuclear families 133 severely myopic (mean spherical...
Most previous studies have found no visual advantage for the use of yellow filters. This study reports effect wearing a long-pass filter on monocular spatial contrast sensitivity under photopic and mesopic conditions. Contrast was improved with conditions but not significantly at most frequencies
purpose. The paired box 6 (PAX6) gene is critical to eye development. Based on prior linkage evidence, this study was conducted investigate the association of PAX6 polymorphisms with high myopia in a Han Chinese population. methods. Tag single nucleotide (tSNPs) locus were selected based HapMap data, and other its functional regions also identified. Both tSNPs identified variants genotyped 164 nuclear families 170 highly myopic (spherical equivalent < −6.0 D both eyes) offspring....
Background The paired box 6 (PAX6) gene is considered as a master for eye development. Linkage of myopia to the PAX6 region on chromosome 11p13 was shown in several studies, but results association between and were inconsistent so far. Methodology/Principal Findings We genotyped 16 single nucleotide polymorphisms (SNPs) its regulatory regions an initial study 300 high cases controls (Group 1), successfully replicated positive with another independent group 299 2). Five SNPs replication...
Abstract Purpose To determine the prevalence and risk factors of myopia‐related retinal changes in H ong K C hinese adolescents with high myopia. Methods A cross‐sectional study on teenage subjects myopia was conducted between January 2005 June 2009. Subjects were recruited via newspaper advertisements, invitation letters to schools, leaflets posters. Data collected included history related progression characteristics. Results In total, 120 (61 boys 59 girls) recruited. The mean age 14.8 ±...
Purpose: To assess the efficacy of Defocus Incorporated Multiple Segments (DIMS) spectacle lens for myopia control and its impact on vision-related quality life in Chinese children over a 1-year period. Methods: This randomized double-blind prospective controlled clinical trial enrolled 176 myopic subjects aged between seven 14 years who were randomly assigned into DIMS group or single-vision (SV) group. Refractive error axial length measurements at baseline, three-, six-, nine-, 12-month...
In most parts of the world, Schirmer test (ST) is still main used by optometrists for assessment tear adequacy in screening potential contact lens wearers and as an aid diagnosis "dry" eye. We tested reliability a 1-min ST nine normal Hong Kong-Chinese (HK-Chinese) subjects during five to seven visits over period 2 weeks. For 4 subjects, consistently measured 0 mm/ 1 min, 68% results were less than 6 mm/1 value suggested lower limit asymptomatic eyes. The obtained inconsistent it concluded...
To investigate the genetic association between transforming growth factor beta1 (TGFB1) gene polymorphisms and high myopia in a Chinese population.Six hundred adults were recruited for this case-control study, including 300 subjects with (-8.0 diopters or worse) control (within +/-1.0 diopters). Seven tag single-nucleotide (SNPs) 1 coding SNP genotyped. Their frequencies compared cases controls by statistical tests.Four SNPs 5' half of showed significant differences allele genotype controls....