A5079388124- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Liver Disease Diagnosis and Treatment
- Software Testing and Debugging Techniques
- Ocular Diseases and Behçet’s Syndrome
- Diabetes Management and Education
- Ocular Surface and Contact Lens
- Ocular Oncology and Treatments
- Retinopathy of Prematurity Studies
- Ophthalmology and Eye Disorders
- Corneal Surgery and Treatments
- Mesenchymal stem cell research
- Retinoids in leukemia and cellular processes
- Autophagy in Disease and Therapy
- Software System Performance and Reliability
- Software Reliability and Analysis Research
- Neuroscience and Neuropharmacology Research
- COVID-19 Clinical Research Studies
- Acute Ischemic Stroke Management
- Ocular Disorders and Treatments
Second Affiliated Hospital of Zhejiang University
2021-2025
Chinese PLA General Hospital
2008-2025
PLA Academy of Military Science
2025
Shanxi Medical University
2024
Second Xiangya Hospital of Central South University
2020-2024
Central South University
2020-2024
Penn State Milton S. Hershey Medical Center
2024
Xuzhou Medical College
2024
Second Affiliated Hospital of Xuzhou Medical College
2024
Zhejiang Hospital
2024
The SARS-CoV-2 RNA has been detected in tears and conjunctival samples from infected individuals. Conjunctivitis is also reported a small number of cases. We evaluated ocular symptoms tropism group patients with COVID-19. Fifty-six were recruited as subjects. Relevant medical histories obtained the electronic record system. Ocular history data by communicating directly Surface Disease Index (OSDI) Salisbury Eye Evaluation Questionnaire (SEEQ) used to assess anterior surface condition before...
Abstract Age-related cell loss underpins many senescence-associated diseases. Apoptosis of lens epithelial cells (LECs) is the important cellular basis senile cataract resulted from prolonged exposure to oxidative stress, although specific mechanisms remain elusive. Our data indicated concomitance high autophagy activity, low SQSTM1/p62 protein level and apoptosis in same LEC patients. Meanwhile, primary cultured LECs model, more durable activation obvious p62 degradation under stress were...
The near work and outdoor activity are the most important environmental risk factors for myopia. However, data from Chinese rural children relatively rare remain controversial. Therefore, purpose of this study was to evaluate relationship both activities with refractive error in China. In cross-sectional study, 572 (65.1%) 878 (6–18 years age) were included Handan Offspring Myopia Study (HOMS). Information parents on these children, as well parent's non-cycloplegic refraction, obtained...
Background: Pathologic myopia (PM) associated with myopic maculopathy (MM) and "Plus" lesions is a major cause of irreversible visual impairment worldwide. Therefore, we aimed to develop series deep learning algorithms artificial intelligence (AI)-models for automatic PM identification, MM classification, lesion detection based on retinal fundus images. Materials Methods: Consecutive 37,659 images from 32,419 patients were collected. After excluding 5,649 ungradable images, total dataset...
To investigate the association of high myopia with polymorphisms in hepatocyte growth factor (HGF) gene, a potential candidate for development.Single nucleotide (SNPs) were screened and identified HGF gene region denaturing high-performance liquid chromatography, their linkage disequilibrium pattern was established Han Chinese population (n=150). Tag SNPs selected genotyped using restriction digestion fluorescence polarization assays 128 nuclear families 133 severely myopic (mean spherical...
purpose. The paired box 6 (PAX6) gene is critical to eye development. Based on prior linkage evidence, this study was conducted investigate the association of PAX6 polymorphisms with high myopia in a Han Chinese population. methods. Tag single nucleotide (tSNPs) locus were selected based HapMap data, and other its functional regions also identified. Both tSNPs identified variants genotyped 164 nuclear families 170 highly myopic (spherical equivalent < −6.0 D both eyes) offspring....
Abstract Globally, cases of myopia have reached epidemic levels. High and pathological (PM) are the leading cause visual impairment blindness in China, demanding a large volume screening tasks to control rapid growing myopic prevalence. It is desirable develop automatically intelligent system facilitate these time- labor- consuming tasks. In this study, we designed series deep learning systems detect PM macular lesions according recent international photographic classification (META-PM)...
Chronic hepatitis B and cirrhosis pose significant global health threats. Few studies have explored the disease burden mortality trend of caused by virus infection among adolescents young adults (AYAs, aged 15-39 years). This study aimed to assess trends. Publicly available data were obtained from 2021 GBD database. The rates incidence, mortality, disability-adjusted life years calculated at global, regional, national levels. Temporal trends assessed using joinpoint regression analysis,...
Glaucoma, a leading cause of irreversible blindness, is characterized by optic neuropathy and retinopathy, with primary open-angle glaucoma (POAG) being the most prevalent form. The pathogenic mechanism POAG involves elevated intraocular pressure caused chronic fibrosis trabecular meshwork (TM). Autophagy, critical process for maintaining cellular homeostasis, has been implicated in across various organs. However, its precise role associated pathogenesis remains unclear. This study...
Chinese traditional "eye exercises of acupoints" have been advocated as a compulsory measure to reduce visual symptoms, well retard the development refractive error, among students for decades. The are comprised 5-min, bilateral eye acupoint self-massage. This study evaluated possible effect these rural students.Eight hundred thirty-six (437 males, 52.3 %), aged 10.6 ± 2.5 (range 6-17) years from Handan Offspring Myopia Study (HOMS) who completed and vision questionnaire, convergence...
Background: Artificial intelligence (AI) has been successfully applied to the screening tasks of fundus diseases. However, few studies focused on potential AI aid medical teaching in residency training program. This study aimed evaluate effectiveness AI-based pathologic myopia (PM) identification system ophthalmology program and assess residents’ feedback this system. Materials Methods: Ninety residents department at Second Affiliated Hospital Zhejiang University were randomly assigned three...
Purpose. To evaluate the corneal aberration changes in dry eye patients after treatment with artificial drops. Methods. Thirty mild to moderate treated drops and twenty comparable were recruited as controls. Anterior aberrations over 3 mm 5 analytical zones including total, 3rd 5th high order (HOAs), spherical (SA), vertical (V-coma) horizontal coma (H-coma) obtained from topography data at baseline 2 weeks evaluated. Results. For zone, trefoils, V-coma, H-coma terms, HOAs significantly...
Abstract The complete genome of Cordyceps militaris was sequenced using single-molecule real-time (SMRT) sequencing technology at a coverage over 300×. size 32.57 Mb, and 14 contigs ranging from 0.35 to 4.58 Mb with an N50 2.86 were assembled, including 4 telomeric sequences on both ends additional 8 either the 5′ or 3′ end. A methylome database constructed SMRT m4C m6A methylated nucleotides, many unknown modification types identified. major methylation motif is GA GGAG, GC CG/GC. In C ....
To evaluate the influence of 2.2 mm clear corneal incision (CCI) features in surgically induced astigmatism (SIA) and higher-order aberrations (HOAs) after cataract surgery.Right eyes 92 subjects receiving surgery were involved. A total 38 categorized as intact group, 54 defective group. Pre- postoperative (1 month 6 months) HOAs on anterior posterior surfaces, volume, thickness (CT) measured using Pentacam. The CCI including length (IL), angles, distance from to central cornea (Dis-En/Ex),...
Abstract The lentivirus–short hairpin RNA (shRNA) system is a widely used tool for interference. Multiple factors may affect the interference efficiency during lentivirus production and transduction procedures. Thus, an optimized protocol required to achieve high‐titer efficient gene delivery. In present study, was produced by transfecting lentiviral transfer packaging plasmids into HEK 293T cells. affecting titer were assessed, including plasmid ratio, type, serum type cell culture,...
Abstract Background Ulmus lamellosa (one of the ancient species ) is an endemic and endangered plant that has undergone climatic oscillations geographical changes. The elucidation its demographic history genetic differentiation critical for understanding evolutionary process ecological adaption to forests in Northern China. Results Polymorphic haplotypes were detected most populations U. via DNA sequencing. All divided into three phylogeographic clades fundamentally corresponding their...
Abstract Purpose: To investigate the influence of eyelid position on wavefront aberrations. Methods: In study 1, right eyes 43 non‐cyclopleged subjects were evaluated using Complete Ophthalmic Analysis System (COAS) aberrometer. 2, 23 cyclopleged Optical Pathway Difference Scan Measurements made with wide‐open and deliberately narrowed palpebral apertures in these subjects. 3, eyelashes COAS output was investigated 20 by placing artificial front eye, close proximity to natural eyelashes....
Self-management in hemodialysis patients is critical for optimal health outcomes. This study aimed to examine the effects of a theory-based micro-video education program on improvement self-management, knowledge, and self-efficacy patients. quasi-experimental employed two group, pre- post-test design. The sample was 80 from dialysis center. participants were assigned 1:1 ratio receive routine care or 3-month program. Between-group comparison showed that intervention group had significantly...
This study aimed to establish and evaluate an artificial intelligence-based deep learning system (DLS) for automatic detection of diabetic retinopathy. could be important in developing advanced tele-screening retinopathy.A DLS with a convolutional neural network was developed recognize fundus images referable A total data set 41,866 color were obtained from 17 cities the Yangtze River Delta Urban Agglomeration (YRDUA). Five experienced retinal specialists 15 ophthalmologists recruited verify...
Synaptic plasticity is critical for brain function, including learning and memory. It regulated by gene transcription protein synthesis as well posttranslational modifications at synapses. Although acetylation has been shown to be involved in the regulation of synaptic plasticity, this was mainly histone acetylation. To investigate whether nonhistone proteins important we analyzed mouse acetylome found that calmodulin (CaM), a ubiquitous Ca2+ sensor, acetylated on three lysine residues,...
To evaluate changes in corneal higher-order aberrations (HOAs) on the anterior and posterior surfaces after 1.8 mm microincision cataract surgery (MICS) 2.8 small-incision (SICS).Eye Department, First Affiliated Hospital, School of Medicine, Zhejiang University, China.Prospective case series.Right eyes patients had MICS or SICS. The preoperative 1-week 3-month postoperative distance visual acuity (CDVA) dry eye-related indices were determined. total HOAs Zernike coefficients (3rd 4th order)...